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  • 1
    Electronic Resource
    Electronic Resource
    Corticotropin releasing hormone in plasma of patients with Cushing's disease (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 529-529 
    Details
    ISSN: 1432-1440
    Keywords: Corticotropin releasing hormone (CRH) ; Cushing's disease ; remission ; transspenoidal surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01721042
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  • 2
    Electronic Resource
    Electronic Resource
    Inconsistent stimulation of plasma ACTH through corticotropin-releasing factor in a patient with central Cushing's disease due to pituitary adenoma (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 475-477 
    Details
    ISSN: 1432-1440
    Keywords: Corticotropin-releasing factor (CRF) ; Cushing's disease ; ACTH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three uncommon findings were observed in a case of Cushing's disease due to macroadenoma: no suppression of plasma ACTH during an 8-mg dexamethasone test, a negative corticotropin-releasing factor test, and a normal X-ray of the sella turcica. Despite these findings, the diagnosis of pituitary was confirmed Cushing's syndrome by computerized tomography and a transphenoidal operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731496
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  • 3
    Electronic Resource
    Electronic Resource
    Carpal tunnel syndrome and acromegaly (1986)
    Springer
    Acta neurochirurgica 83 (1986), S. 54-55 
    Details
    ISSN: 0942-0940
    Keywords: Carpal tunnel syndrome ; Acromegaly ; electroneurographic findings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 50 patients with acromegaly and carpal tunnel syndrome have been examined electrophysiologically before and after transnasal operation of the pituitary adenoma. 32 of the 50 patients (64%) had symptoms of carpal tunnel syndrome. 13 of them had neurological deficits. 28 of the examined patients had pathological neurographical findings only. About 1 week post-operatively DL was decreased in 43%; in 10 out of 13 patients with neurological deficits DL decreased. GH was normalized in 80% and reduced to 5–10Μg/1 in a further 10%. The investigation did not show whether the carpal tunnel syndrome only depended on a GH increase or on other factors also such ase.g., on the duration of symptoms or tissue changes. None of the patients had the transversal carpal ligament operated on. The coincidence between acromegaly and carpal tunnel syndrome was 64%. In 3 cases the carpal tunnel syndrome was the leading sign to the diagnosis of acromegaly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01420508
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  • 4
    Electronic Resource
    Electronic Resource
    Tumour ploidy in DNA histograms of pituitary adenomas (1985)
    Springer
    Acta neurochirurgica 76 (1985), S. 18-22 
    Details
    ISSN: 0942-0940
    Keywords: Flow cytometry ; DNA-histogram ; pituitary adenoma ; tumour ploidy ; mitosis ; recurrences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary DNA analysis was performed by flow cytometry (FCM) in 59 cases of different types of pituitary adenomas who underwent microsurgery and were actively followed over a period of 3–6 years. Aneuploid DNA patterns were detected in 12 (20%) cases. Frequency of aneuploidy was highest in prolactin-secreting (36%) as compared to 17% in GH- and 7% in non-secreting adenomas. Some adenoma parameters valid for tumour growth, such as rate of recurrences and mitotic index, were correlated with aneuploidy of the tumour. FCM studies are, therefore, recommended to gain further parameters for the estimation of proliferative activity of pituitary adenomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01403824
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  • 5
    Electronic Resource
    Electronic Resource
    The choice of treatment after incomplete adenomectomy in acromegaly: Proton- versus highvoltage radiation (1989)
    Springer
    Acta neurochirurgica 96 (1989), S. 32-38 
    Details
    ISSN: 0942-0940
    Keywords: Acromegaly ; growth hormone ; radiotherapy ; proton irradiation ; transsphenoidal microsurgery ; pituitary function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors report the results of a study designed to compare the effectiveness of two different types of radiation in patients with acromegaly where surgical therapy had failed to normalize growth hormone (GH). Longterm follow-up after conventional high voltage radiation in 17 patients and proton therapy in 13 patients confirmed a similar reduction of GH levels in both groups. After 4.5 years a decrease of about 80% was achieved. After “conventional radiation” GH was normal in 8 (47%) and near normal in 6 (35%) while proton therapy resulted in normalization in 5 and improvement in 5 (38%). The slightly better results of “conventional radiation” must be attributed to lower pretreatment levels of GH. Side effects as additional pituitary deficits and oculomotor palsies were more often seen after proton treatment. Since the results of both radiation methods are similar and proton therapy has a tendency to more serious side effects we recommend “conventional radiation” as secondary treatment of acromegaly.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01403492
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  • 6
    Electronic Resource
    Electronic Resource
    Aspects of personality in patients with pituitary adenomas (1986)
    Springer
    Acta neurochirurgica 83 (1986), S. 8-11 
    Details
    ISSN: 0942-0940
    Keywords: Pituitary tumours and personality ; pituitary tumours and anxiety ; acromegaly and Cushing's disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 24 patients suffering from pituitary tumours, aspects of personality as covered by the FPI (Freiburger Personality Inventory), the Gie\en test and the STAI (State-Trait-Anxiety Inventory) were investigated in order to find out changes or problems which demand special treatment. The most interesting result concerns state and trait-anxiety scores being increased pre-surgically and normalizing to some extent after treatment. Most of the other explored aspects did not show but tendencies which demand further investigation. Relationships between hormone levels and tumour size could not be shown. As a result of this investigation, special psychological treatment should be considered in acromegaly and Cushing's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01420501
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  • 7
    Electronic Resource
    Electronic Resource
    Transnasal surgery in the treatment of craniopharyngiomas (1986)
    Springer
    Acta neurochirurgica 83 (1986), S. 1-7 
    Details
    ISSN: 0942-0940
    Keywords: Craniopharyngiomas ; transnasal surgery ; endocrinological and ophthalmological outcome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The results of transnasal-transsphenoidal surgery in 31 patients with craniopharyngioma are evaluated. To assess the value of transnasal surgery in cases with visual impairment, the results are compared to cases operated transcranially. There was only one death occurred on the 5th postoperative day. Two patients developed rhinoliquorrhoea, and one a transient oculomotor palsy. Recurrences leading to re-operation occurred frequently after mere cyst aspiration and only once after subtotal tumour removal. Normal glandotrope functions of the hypophysis were preserved in 75%, disturbed functions were normalized in 19% of primary transnasal surgery. Visual disturbances were normalized or improved in 94% cases after transnasal surgery, whereas an improvement was observed in only 65% after transcranial surgery. A deterioration never appeared after transnasal surgery, but in 26% after transcranial operations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01420500
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  • 8
    Electronic Resource
    Electronic Resource
    Cushing's disease due to an unusually large adenoma of the pituitary gland in infancy (1985)
    Springer
    European journal of pediatrics 143 (1985), S. 221-223 
    Details
    ISSN: 1432-1076
    Keywords: Cushing's disease ; Pituitary adenoma ; Infancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report an 18-month-old girl with Cushing's disease caused by a large adenoma of the pituitary gland. Tumour size and extension were determined by X-ray, CT-scan and angiographic studies. The endocrinological findings were typical for this disease: elevated plasma levels of ACTH, cortisol, 17-Hydroxyprogesterone (17-OHP) and testosterone, elevated urinary excretion of 17-Ketosteroids (17-KS) and 17-Hydroxycorticoids (17-OHCS). Dexamethasone failed to suppress ACTH and cortisol plasma levels. TRH induced only a minimal TSH increase. Following LH-RH injection gonadotropin levels rose to pubertal values. The hGH response to insulin-induced hypoglycaemia was subnormal. After resection of the tumour the infant died because of non-treatable arrhythmia. Histological findings showed a non-differentiated adenoma with extension into the subarachnoid space and into nerve tissues. In vitro lysine-vasopressin (LVP) and arginine-vasopressin (AVP) exhibited only weak stimulatory effects on the ACTH secretion of the tumour cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442145
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