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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 245 (1989), S. 714-715 
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1335
    Keywords: Neuron-specific enolase ; Medullary thyroid carcinoma ; Tumor marker ; Calcitonin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuron-specific enolase (NSE) is an enzyme detectable in nervous and neuroendocrine tissue. Increased serum levels of NSE are found in small cell lung cancer and in patients with neuroblastoma, in whom NSE is used as a serum tumor marker. We have investigated 32 patients with histologically proven medullary thyroid carcinoma, a tumor of neuroendocrine origin, in which the classical tumor marker calcitonin (CT) was pathologically elevated. Positive immunocytochemistry for NSE and CT in C-cells was obtained in all cases. Increased serum NSE levels were found in only 5 of 32 patients, there was no correlation between NSE and CT concentrations. We also compared NSE and CT serum levels during long-term follow-up and again found no correlation between NSE and CT. After i.v. stimulation tests with pentagastrin and calcium, no correlation was found between NSE and CT serum levels. We conclude, therefore, that in medullary thyroid carcinoma NSE is useful for immunocytochemistry but not a reliable serum tumor marker.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 369 (1986), S. 727-727 
    ISSN: 1435-2451
    Keywords: Splenectomy ; Milzexstirpation ; Milzfolgen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In zwei retrospektiven Untersuchungen werden mögliche langfristige Folgen des Milzverlustes, wie Sepsis, Pneumonie, Thrombose und Infarktrisiko analysiert. In einer Patientenumfrage (n = 77) 0,5–35 Jahre nach Splenektom wegen Traumas, konnte keine Erhöhung der Sepsis und Pneumonierate beobachtet werden. Unter 38 632 Obduktionen wurden die Todesursachen der Obduktionen nach Splenektomie (n = 331) analysiert. Eine Todesursachenhäufung nach Splenektomie, wie Sepsis, Thrombose und Infarkt, kann nicht festgestellt werden.
    Notes: Summary The long-term complication rate following splenectomy was investigated in two retrospective studies analysing the incidence of sepsis, pneumonia, thrombosis and myocardial infarction. The follow-up included 77 patients who had untergone splenectomy 0.5–35 years previously due to traumatic rupture. No significant increase in the incidence of sepsis or pneumonia could be detected. Postmortem examinations of 38,632 patients included 331 cases with splenectomy. The incidence of sepsis, thrombosis or myocardial infarction as the cause of death was no higher among patients who had undergone splenectomy.
    Type of Medium: Electronic Resource
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