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  • 1
    Electronic Resource
    Electronic Resource
    Chromogranin A and B and secretogranin II in bronchial and intestinal carcinoids (1987)
    Springer
    Virchows Archiv 412 (1987), S. 103-109 
    Details
    ISSN: 1432-2307
    Keywords: Carcinoids ; Bronchial carcinoids ; Intestinal carcinoids ; Chromogranin A ; Chromogranin B ; Secretogranin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Carcinoid tumours (bronchial and intestinal) were analyzed by immunoblotting for the presence of chromogranin A, B and secretogranin II. In all tumours an antigen corresponding in electrophoretic behaviour to adrenal chromogranin A was present. Lung carcinoids (3 out of 5) contained a relatively high concentration of a proteoglycan form of this antigen in addition. Chromogranin B was found in all tumours. In one and two dimensional immunoblotting it appeared identical to the corresponding adrenal antigen. Secretogranin II was also present, however concentrations (especially in intestinal carcinoids) were low and variable. Furthermore, in intestinal tumours it differed from the adrenal antigen by having a slightly higher molecular size and a more alkaline pI. Immunohistochemistry revealed that the tumour tissues stained positively for all three antigens. For secretogranin II the staining in intestinal tumours was relatively weak and quite variable. These results should provide a defined basis for immunohistochemical screening of carcinoids for the chromogranin/secretogranin antigens.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00716181
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  • 2
    Electronic Resource
    Electronic Resource
    Putative neurotransmitters in the retinae of three urodele species (Triturus alpestris, Salamandra salamandra, Pleurodeles waltli) (1988)
    Springer
    Cell & tissue research 252 (1988), S. 317-328 
    Details
    ISSN: 1432-0878
    Keywords: Retina ; Gamma-aminobutyric acid (GABA) ; Serotonin ; Neuropeptides ; Urodele amphibians (Triturus alpestris, Salamandra salamandra, Pleurodeles waltli)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The immunocytochemical localization of several substances with putative neurotransmitter or modulator properties was investigated in the retinae of three urodele species. Gamma-aminobutyric acid-like immunoreactive labelling appeared in different types of amacrine and horizontal cells. In addition, labelled fibres in the optic nerve were detected. It was not possible to determine whether these fibres were ganglion-cell axons or part of an efferent projection. Endogenous serotonin was found in several populations of amacrine cells including stratified and diffuse types. Glucagon-like immunoreactivity appeared in one bistratified amacrine cell type, and neurotensin-like immunoreactivity was detected in a single monostratified amacrine cell type. Metenkephalin-like-immunoreactive labelling was rare but found in several sublaminae of the inner plexiform layer. Thus each peptide-like-immunoreactive cell type makes up a distinct and unique population of cells and probably has a special functional role in retinal processing. There are striking similarities in the peptide-like immunoreactive patterns of Triturus alpestris and Necturus maculosus whereas in Ambystomatidae the peptide-like-immunoreactive systems appear to be differently organized. This supports the hypothesis that Salamandridae and Proteidae are more closely related to each other than to the Ambystomatidae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214374
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    An immunological study on chromogranin A and B in human endocrine and nervous tissues (1989)
    Springer
    Journal of molecular histology 21 (1989), S. 365-372 
    Details
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Antisera were raised against synthetic peptides derived from the primary amino acid sequence of human chromogranin B. These antisera recognized in one- and two-dimensional immunoblotting a component previously designated as chromogranin B. In human chromaffin granules, the major endogenous processing product of chromogranin B is formed by proteolytic cleavage of the protein near theC-terminus. Immunohistochemical localizations were obtained with antisera against human chromogranins A and B and against a synthetic peptide corresponding to the B sequence. In human tissues, chromogranin B is co-stored with chromogranin A in the adrenal medulla, the anterior pituitary, parafollicular cells of the thyroid, in some cells of the endocrine pancreas and in some enterochromaffin cells, whereas only chromogranin A is found in the parathyroid gland and enterochromaffin cells of the gastric corpus mucosa. In the nervous system, no immunostaining was observed for chromogranin A and only a weak one for chromogranin B in some cells of the spinal cord. However, the Purkinje cells of the cerebellum were strongly positive for chromogranin B.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01798500
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Chemical limnology of Georgian Bay and the North Channel between 1974 and 1980 (1988)
    Springer
    Hydrobiologia 163 (1988), S. 77-83 
    Details
    ISSN: 1573-5117
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Intensive surveys of Georgian Bay and the North Channel were done in 1974 and 1980. This paper reviews the main findings of the surveys and describes the main factors that determine the chemistry of the two water bodies. Georgian Bay is oligotrophic. Its chemistry is determined chiefly by natural phenomena, specifically the geology of the drainage basin and the river runoff in the spring, and by exchange with Lake Huron and the North Channel. Localized eutrophication is found in the bays along the southern shore. The chemistry of the North Channel is determined by its very short residence time — about two years — caused by the large inflow from St. Mary's River. The water quality in the river reflects that of Lake Superior and the inputs of nutrients and contaminants from Sault Ste. Maire. Because of the short flushing time, the Channel remains oligotrophic despite the large loadings of phosphorus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00026921
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    Paper (German National Licenses)
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