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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 61 (1983), S. 163-164 
    ISSN: 1432-1440
    Keywords: Luminescence ; Blood bactericidal activity ; Phagocytosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate phagocytosis of granulocyte, chemiluminescence (CL) — measurements were done in whole blood specimen. By this method much less variation (22% versus 84%) could be achieved in the whole blood specimen compared with isolated granulocytes. The quenching of CL by erythrocytes, which is dependent on the quotient erythrocytes/granulocytes, could be significantly reduced by dilution (1:5,000). Optimized reaction conditions were selected (approx. 5 × more sensitive then previous protocols) to evaluate the phagocytic activity of the few remaining granulocytes (approx. 2,000/ml) with routine luminometers.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-2451
    Keywords: Polytrauma ; Plasminogen activator ; Fibrinolysis ; Polytrauma ; Plasminogenaktivator ; Fibrinolyse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Vorhandensein des gewebeständigen Plasminogenaktivators nach Polytrauma wurde experimentell bei Ratten und klinisch bei Patienten fibrinolyseautographisch nachgewiesen. Nach Gabe des natürlichen Proteinaseninhibitors Aprotinin war der gewebeständige Aktivator unvermindert vorhanden, während eine Applikation des synthetischen Fibrinolyseinhibitors trans-Amcha den Aktivatorgehalt in den Rattenlungen reduzierte. Der Plasminogenspiegel der Patienten war normal und gewährleistet zusammen mit dem Gewebeaktivator die Voraussetzung für eine ungestörte Fibrinolyse nach Polytrauma.
    Notes: Summary The presence of the tissue-bound plasminogen activators during the posttraumatic period was shown by fibrinolysis-autography in experimental studies in rats and clinically in patients. After application of the natural proteinase inhibitor Aprotinin the tissue-bound activator was not reduced, whereas the application of the synthetic fibrinolysis inhibitor trans-Amcha decreased the activator content in the lungs of rats. Plasminogen values were in the normal range. The presence of plasminogen and its substrate, the tissue-bound activator, is an adequate condition for a normal fibrinolysis.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 342 (1976), S. 621-621 
    ISSN: 1435-2451
    Keywords: Hip ; Bone cement ; Embolism, fat ; Knochenzement ; Hüfte ; Fett ; Embolie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Durch das Einpressen von Knochenzement in den Markraum des Oberschenkelknochens, kommt es zu akuten Drucksteigerungen. Die Folge ist eine Mark- und Fettintravasation, welche zu einer mechanischen Blockade der Mikrozirkulation in der Lunge führt. Ebenso kommt es auch zum Übertritt von thromboplastischen Substanzen. Eine rechtsventrikuläre Ausflußblockade, die zum akuten Cor pulmonale führen kann, ist möglich. Als prophylaktische Maßnahme, Druckausgleich im Markraum durch Drainage und Sog, sowie die Anwendung eines natürlichen Proteinaseninhibitors Aprotinin zur Hemmung des Thrombocytensturzes wird empfohlen.
    Notes: Summary The pressing of bone cement into the medullary space of the femur causes acute presure increases. The consequence is a marrow and fat intravasation leading to mechanical blocking of the microcirculation in the lung, which also entails the transfer of thromboplastic substances. A ventricular obstruction of the outflow is possible. As a prophylactic measure, pressure compensation within the medullary space by means of drainage and suction is recommended, as is the application of the natural proteinase inhibitor aprotinin to prevent a fall in the platelet count.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1435-2451
    Keywords: Lung edema ; Polytrauma ; Leukocyte ; Kininogenase ; Lungenödem ; Polytrauma ; Leukocyten ; Kininogenase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In experimentellen Untersuchungen wurden Zusammenhänge zwischen posttraumatischen leukocytären Infiltrationen des Lungeninterstitiums und ödematösen Lungenveränderungen aufgezeigt. Aus menschlichem Frischblut wurden Leukocytenkonzentrate hergestellt, deren Lysosomen isoliert und Enzyme extrahiert. Vier neutrale Proteinasen konnten nachgewiesen und durch ihre spezifischen Substrate Bowie ihr Inhibitorspektrum charakterisiert werden. Die leukocytäre Kininogenase ist durch den therapeutisch anwendbaren polyvalenten Proteinaseninhibitor Trasylol®, hemmbar. In Tierversuchen wurde die pathogenetische Bedeutung der Kinine für die Ödembildung nachgewiesen. Der polyvalente leukocytäre Proteinaseninhibitor ist nur in geringer Menge nachweisbar.
    Notes: Summary Experimental investigations were carried out to correlate posttraumatic leukocyte infiltration of lung interstitium and edema formation. From human leukocyte lysosomes, four different neutral proteinases could be extracted and characterized by means of their specific substrates and their inhibitor spectra. Granulocyte kininogenase was sensitive to inhibition by Trasylol®, a polyspecific therapeutic proteinase inhibitor. In morphologic experiments on rabbits, the participation of kinins in the events leading to pulmonary edema is made obvious. The existence of small amounts of a polyvalent proteinase inhibitor of leukocyte origin could be shown.
    Type of Medium: Electronic Resource
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