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  • 1
    Electronic Resource
    Electronic Resource
    New isocyanide-platinum complexes (1971)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 93 (1971), S. 5424-5433 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00750a019
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Bibliography on Chemical Wastes (1947)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 39 (1947), S. 676-682 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50449a025
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  • 3
    Electronic Resource
    Electronic Resource
    Reactions of methyl- and phenylplatinum(II) complexes with isocyanides. Mechanism of the insertion reaction (1973)
    s.l. : American Chemical Society
    Inorganic chemistry 12 (1973), S. 1471-1477 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic50125a002
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  • 4
    Electronic Resource
    Electronic Resource
    Evaluation of the photocontact allergenic potential of 6-methylcoumarin in the guinea pig (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 6 (1980), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 6-Methylcoumarin was tested in a new animal model developed for the predictive evaluation of photocontact allergenic potential. Negative results were obtained and these are discussed with respect to inherent limitations of the animal model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1980.tb04930.x
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  • 5
    Electronic Resource
    Electronic Resource
    Predictive animal testing for photocontact allergenicity (1980)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 103 (1980), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this investigation was to establish a standardized animal model to predict the photoallergenic potential of new chemical compounds. In a first series of experiments the main factors influencing the induction of photoallergenicity were evaluated (induction concentration, pH of the test solution, pretreatment of the irradiation site with sodium lauryl sulphate, additional use of adjuvant injections and routes of administration). Osram Ultravitalux lamps were utilized for these studies.In a second series of experiments a Xenon 6000 W radiation source was used. Positive results were obtained with well known photosensitizers, as, for instance, the halogenated salicylanilides, as well as with so-called weak photoallergens (e.g. bithionol, sulphanilamide) by stimulating the animals' immune system with Freund's complete adjuvant.The photoallergenic compounds were at the same time tested for their contact allergenic potential in the optimization test.A standard procedure for the predictive photoallergenicity assay in guinea-pigs is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1980.tb01681.x
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  • 6
    Electronic Resource
    Electronic Resource
    Quantitation of noradrenaline fluorescence in the superior cervical ganglion of the rat and the effect of postganglionic axotomy (1974)
    Springer
    Cellular and molecular life sciences 30 (1974), S. 37-38 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Die mikrofluorimetrische Messung der spezifischen Katecholaminfluoreszenz von sympathischen Neuren im Ganglion cervicale superius der Ratte ergab eine reziproke Beziehung zwischen apparentem Noradrenalingehalt und Perikaryonvolumen. Der totale Katecholamingehalt der Neuren sowie die qualitativ erfasste Azetylcholinesterasektivität erschienen von der Zellgrösse unabhängig. Diese Beziehung war nach postganglionärer Axotomie verändert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01921582
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  • 7
    Electronic Resource
    Electronic Resource
    Comparative dominant lethal studies with phenylbutazone, thio-TEPA and MMS in the mouse (1971)
    Springer
    Cellular and molecular life sciences 27 (1971), S. 1050-1052 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Im Gegensatz zu Thio-TEPA (N, N′, N″-Triaethylen-thiophosphoramid) und MMS (Methansulfonsäuremethylester) führten i.p. Dosen von Phenylbutazon (50 und 100 mg/kg) bei der Maus, unter Berücksichtigung von post- und prae-implantativen Gestationsstadien, zu keinen genetischen Effekten im Sinne der Induktion von dominanten Letalfaktoren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02138874
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  • 8
    Electronic Resource
    Electronic Resource
    Induced dominant lethals in female mice: Effects of triaziquone and phenylbutazone (1973)
    Springer
    Cellular and molecular life sciences 29 (1973), S. 190-192 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Bei weiblichen Mäusen induzierte Triaziquon unter konventionellen Laboratoriumsbedingungen dominante Letalfaktoren, wenn die Substanz im Pro-Oestrus oder im Oestrus verabreicht wurde. Weniger gut geeignet erwies sich diese Applikation wenige Stunden nach Kopulation, da embryotoxische Wirkungen auftraten. Im Gegensatz zu Triaziquon führte Phenylbutazon — weiblichen Mäusen im Oestrus verabreichtnicht zu dominanten Letaleffekten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01945469
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  • 9
    Electronic Resource
    Electronic Resource
    The effect of short term exposures to 100% oxygen on the fine structure of proximal convoluted tubules (1970)
    Springer
    Cellular and molecular life sciences 26 (1970), S. 1124-1125 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Des rats ont été maintenus dans une athmosphère d'oxygène pur sous une pression de 600 mm de mercure durant des périodes de 3 et 7 jours. Les observations faites au microscope électronique sur les tissus prélevés dans le rein ont montré qu'après 7 jours de traitement les mitochondries et les particules de corps gras ont subi dans la cellule d'importantes modifications. Après 3 jours seulement, on n'observait accun changement de l'ultrastructure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02112713
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  • 10
    Electronic Resource
    Electronic Resource
    What can specific behavioural testing procedures contribute to the assessment of neurotoxicity in laboratory animals? (1984)
    Springer
    Inflammation research 14 (1984), S. 131-138 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Subchronic testing of laboratory animals in accordance with present regulatory guidelines involves maximum exposure with the chemical under investigation and serves for the evaluation of systemic toxicity as well as of lesions in organs and organ systems, including neurotoxicity. The primary assessment of neurotoxicity is essentially based on the overall observation of animal behaviour in the course of the customary toxicity studies and on the subsequent neuropathological evaluation with contemporary techniques. Under this maximum exposure the absence of symptoms and signs of neural abnormalities indicates that the material testd would be devoid of neurotoxicity. Any overt or suspicious symptoms for neurotoxicity appearing in the course of subchronic testing may be further characterized with additional functional tests such as neurological examination, electrodiagnostics and possibly with specific behavioural tests. The subsequent neuropathological investigation would have to be expanded to include a detailed evaluation of all neural structures possibly related with the above functional derangements. In case of relevant neurotoxicity subsequent specific behavioural tests might include the evaluation of complex neural functions such as integrated psycho-neuro-motor activity and memory. These behavioural tests might help to explain neurotoxicity and to assess behaviour at low levels of exposure. The implementation of such specific behavioural testing procedures beyond the scope of routine toxicity studies would require a group of investigators capable to earry out appropriate tests. The introduction of such testing will therefore have to be evaluated competitively regarding costs versus the advantages offered by the refinement of the other testing procedures for neurotoxicity including the neuropathological techniques. The performance of behavioural tests without preceding or concomitant toxicological evaluation is not considered to be a feasible approach.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01966846
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