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  • 1980-1984  (3)
  • 1965-1969  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Renale Clearance mit131J-markiertem Chlorjodpropyl-Inulin (1968)
    Springer
    Journal of molecular medicine 46 (1968), S. 264-266 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In the 1st group of 10 patients inulin clearances were performed with J-131 labelled chlorjodpropyl-inulin and with inactive inulin simultaneously. The results were in good agreement. In the 2nd group of 11 patients only the clearance of J-131-inulin was measured. It is possible to reduce errors and time involved in the conventional method by using radioactive labelled inulin. The radioactive technique did not give identical results of the indirect clearance and the direct clearance calculated aftervan Slyke. The results of this investigation suggest that, at present, there is no simple and accurate method which could replace the method byvan Slyke. The uptake of free J-131 by the thyroid accounted for 5.6 to 7.6% of the dose injected. This uptake was reduced to 0.2% by prior treatment with Lugol's solution.
    Notes: Zusammenfassung Nachdem vergleichende Untersuchungen an 10 Patienten eine gute Übereinstimmung der Clearance mit inaktivem und131J-markiertem Chlorjodpropyl-Inulin ergeben hatten, wurden 11 weitere Patienten nur mit der131J-Inulin-Clearance untersucht. Die Verwendung von radioaktiv markiertem Inulin verringert die Fehlermöglichkeiten dieser Nierenfunktionsprobe und setzt den zeitlichen Aufwand für die Inulinbestimmung erheblich herab. Bei 11 Patienten wurde der Inulinverteilungsraum nicht wie bei der ersten Gruppe mit 5,0 g sondern mit 8,0 bis 10,0 g inaktivem Inulin aufgefüllt. Trotz dieser veränderten Technik konnten keine übereinstimmenden Ergebnisse zwischen der nachvan Slyke errechneten und der totalen Clearance erzielt werden. Für die klinische Anwendung ist nach unseren Untersuchungen die van Slykesche Methode noch nicht durch eine einfachere und genauere Methode ersetzbar. Die Aktivitätsaufnahme der Schilddrüse für abgespaltenes131J lag zwischen 5,6 und 7,6% der injizierten131J-Inulindosis. Durch Vorbehandlung mit Lugolscher Lösung ließ sie sich auf 0,2% herabsetzen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01770884
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of left ventricular regional motility: A comparison of different methods (1984)
    Springer
    European journal of nuclear medicine 9 (1984), S. 205-208 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Multiple gated blood pool (MUGA) and contrast ventriculographic studies were performed within 24 h in 80 patients, 20 with 120 normokinetic wall segments and 60 with wall motion abnormalities in 239 of 360 wall segments. Three methods of evaluation of the radionuclide ventriculograms were compared with the results of the biplane contrast ventriculography which served as a standard: (1) qualitative analysis of the cine mode, (2) analysis of parametric scans (amplitude and phase images) and the phase histogram obtained by Fourier analysis, (3) quantitative determination of regional ejection fraction. Normal values were obtained from 20 patients with normal wall motion in the contrast angiogram. The overall sensitivity for the detection of wall motion abnormalities of high degree was 96% for method 1, 95% for method 2, and 90% for method 3, for those of low degree 72% for method 1, 63% for method 2, and 75% for method 3. Combining methods 2 and 3 the sensitivity was increased to 99% for high grade and to 81% for low grade wall motion abnormalities. The two methods showed a complementary effect because of different sensitivities in dependence of the localization of the wall motion abnormality. Although a high efficiency for the evaluation of left ventricular function was provided by the qualitative analysis of the cine mode the combination of Fourier analysis and the determination of regional ejection fraction should be preferred. It increases the sensitivity for the detection of wall motion abnormalities. Moreover, it offers quantitative data which improve the reproducibility and decrease the observer variability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00448540
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    External radiation exposure of personnel working with 99mTechnetium (1982)
    Springer
    European journal of nuclear medicine 7 (1982), S. 237-239 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Radiation from 99mTc was measured at typical locations in those areas of a nuclear medicine department where approximately 50 Ci 99mTc is used per year. In addition, measurements of shielded and unshielded syringes containing 99mTc-labelled radiopharmaceuticals were carried out. From these data radiation exposure of hands and of the whole body of personnel was calculated, taking into consideration the mean working times in the areas and the times of direct and indirect handling of 99mTc. They were compared with the mean values obtained by personnel dosimetry through quartz fibre pocket dosimeters and TLD finger ring dosimeters. The whole body radiation calculated from local measurements for technicians (163±15 mR/year) (mean±SE) and for physicians (260±15 mR/year) was very low judged by the maximum permissible dose of 5,000 mrem/year and correlated well with those of personnel dosimetry (165±15 R and 265±15 R/year respectively). Although local radiation was rather high during generator elution and while preparing radiopharmaceuticals (13±1.2 mR/h) the radiation exposure to the hands of the radiochemists measured by the TLD finger ring dosimeter was low (2.6±0.2 R/year). This was attained by consistently using long distance tools in order to avoid direct contact with 99mTc-containing vials and syringes. The most critical point of radiation exposure in our investigation were the finger tips during injection of 99mTc, when syringe shielding was not used (80–130 mR/injection of 10 mCi). Under our conditions this amounts to 330–560 R/year when a total of 40 Ci is injected by the same physician. This by far exceeds the maximum permissible dose of 60 rem/year. The dose can be reduced extensively to only 2–3 R/year when tungsten shielding of the syringe is consistently used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256472
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Validity of different gated equilibrium blood pool methods for determination of left ventricular ejection fraction (1980)
    Springer
    European journal of nuclear medicine 5 (1980), S. 439-445 
    Details
    ISSN: 1619-7089
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Left ventricular ejection fractions (EF) were determined in 37 patients by biplane cineventriculography (Angio) and by four modifications of the gated equilibrium blood pool (GBP) method: 1. Region of interest (ROI) in enddiastole (ED), correction by external background 2. ROI in ED, correction by internal background between ED and endsystole (ES) 3. ROI in ED (maximum) and ES (minimum); no background correction 4. ROI in ES, correction by background between ED and ES. EFGBP were determined after injection of 20 mCi 99mTc human albumin (Anger-camera, all-purpose collimator, 16 ECG-segments, 64 x 64 matrix with 1.5 zoom). EF by biplane angiography (EFangio) was calculated by the formula of Dodge. The following correlation between angiographically and scintigraphically determined EF's were found: $$\begin{gathered} EF_{GBP 1} = 0.504 EF_{angio} + 8.08, \hfill \\ EF_{GBP 2} = 0.847 EF_{angio} + 10.0, \hfill \\ EF_{GBP 3} = 0.911 EF_{angio} + 3.75, \hfill \\ EF_{GBP 4} = 0.648 EF_{angio} --- 3.51 \hfill \\\end{gathered}$$ Intraobserver variability of GBP method 2 and 3 was±5%. EFs determined by GBP methods 2 and 3 are as accurate as the EFs determined by cineventriculography.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00261789
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    Paper (German National Licenses)
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