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  • 1980-1984  (3)
  • 1955-1959
  • 14C-(U)-glucose  (1)
  • Angiotensin-Converting Enzyme  (1)
  • Bone marrow culture  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Angiotensin Converting Enzyme (ACE) Ein in vitro-Test für die Sarkoidose-Diagnostik (1980)
    Springer
    Journal of molecular medicine 58 (1980), S. 195-198 
    Details
    ISSN: 1432-1440
    Keywords: Angiotensin converting enzyme ; Sarcoidosis ; Granulomatous diseases ; Clinical diagnosis ; Angiotensin-Converting Enzyme ; Sarkoidose ; Granulomatosen ; klinische Diagnostik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 50 Patienten mit Sarkoidose (39 mit aktiver, 11 mit inaktiver Sarkoidose) wurde das Angiotensin-converting enzyme (ACE) im Serum bestimmt. Die Gruppe der Kontrollpatienten umfaßte 50 Personen (34 mit chronischen Lungenerkrankungen, 9 mit Morbus Hodgkin, 7 mit chronischer Polyarthritis). Der Unterschied der Mittelwerte der ACE-Aktivität war zwischen Sarkoidosepatienten (28,6±11,4) und Kontrollpatienten (14,8±4) hochsignifikant (p〈0,001). Ebenso fand sich ein deutlicher Unterschied zwischen Patienten mit aktiver (32,8±11) und inaktiver Sarkoidose (21,9±5,1) mit einemp〈0,001. Corticosteroide senken die ACE-Aktivität bei Sarkoidosepatienten deutlich, ohne daß dies als Hinweis für eine Besserung der Sarkoidose gewertet werden kann. Die gesteigerte ACE-Aktivität bei anderen epitheloidzelligen Granulomatosen (biliäre Zirrhose, Morbus Gaucher, Lepra, Asbestose) repräsentiert möglicherweise einen mit der Sarkoidose gemeinsamen pathophysiologischen Mechanismus.
    Notes: Summary Serum angiotensin-converting enzyme (ACE) was studied in 50 patients with sarcoidosis (39 active, 11 inactive) as well as in 50 control patients (34 with chronic nonspecific lung disease, 9 with Hodgkin and 7 with rheumatoid arthritis). There was a significant difference of ACE activity between sarcoidosis patients (28.6±11.4) and controls (14.8±4), and also between active (32.8±11) and inactive (21.9±5.1) sarcoidosis (p〈0.001). Coricosteroid treatment seems to lower ACE activity in patients with sarcoidosis without offering a clue for clinical improvement. Increased ACE activity in other granulomatous disorders is being discussed. ACE activity thus proves to be a valuable test especially in differentiating active from inactive sarcoidosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476778
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  • 2
    Electronic Resource
    Electronic Resource
    Cellular aggregates in bone marrow cultures of patients with acute myeloid leukemia (1982)
    Springer
    Annals of hematology 44 (1982), S. 329-338 
    Details
    ISSN: 1432-0584
    Keywords: Acute myeloid leukemia ; Bone marrow culture ; Cellular aggregates ; Bone marrow stroma ; Adipocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We describe the incidence and morphology of cellular aggregates which may develop in 8 day bone marrow (BM) cultures of patients with acute myeloid leukemia (AML). Aggregates formed in at least one BM culture from 50% (20/39) of the AML group. They developed irrespective of the patient's status (i.e. stages M1–M4), FAB type, and presence of colony stimulating factor (CSF). All aggregates were composed of macrophages, plasma cells, and cells of the myelocyte series surrounding a core of adipocytes and collagen fibrils. The percentage of blasts and promyelocytes in the plated BM aspirate governed the final composition of the aggregate. Patients in Stages M3 or M4 with FAB types M1 or M2 formed aggregates with a high proportion of myelocytic cells; aggregates of all other AML patients were composed predominantly of macrophages and plasmacytes. Aggregates appeared to form as a result of attraction of cells in the medium toward the stroma cell core. Furthermore, the development of aggregates in the absence of exogenous CSF, suggested that stromal cells excreted a factor with CSF-like activity. The results indicate that cellular aggregates in AML-BM cultures reflect the important role of BM stroma in creating microenvironments which enhance the development of hemopoietic stem cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319916
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    In vivo glucose turnover in hypo- and hyperthyroid starved rat (1980)
    Springer
    Pflügers Archiv 386 (1980), S. 47-52 
    Details
    ISSN: 1432-2013
    Keywords: 3H-(2)-glucose ; 14C-(U)-glucose ; Glucose turnover ; Glucose recycling ; Thyroid state
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of hypo- and hyperthyroidism on glucose turnover in vivo was determined in unanesthetized rats starved for 48 h. Glucose pool and decay rate of specific radioactivity of blood glucose was measured after bolus injection of a mixture of3H-(2)- and14C-(U)-glucose under steady state conditions. Compared with euthyroid controls (=100%), hypothyroidism resulted in a decrease of blood glucose concentration (81%), glucose pool (52%), glucose disappearance rate (39%), and total glucose recycling (12%). In contrast, hyperthyroidism led to an increase of blood glucose concentration (148%), glucose pool (121%), glucose disappearance rate (185%), and and total glucose recycling (163%).T 1/2 for glucose was calculated to be 46 min in the hypo-, 34 min in the eu-, and 22 min in the hyperthyroid state. The concentration of circulating glucoregulatory hormones, corticosterone and glucagon were elevated in hyperthyroid rats, while glucagon was diminished in hypothyroid animals. No difference in the level of insulin was found. These data demonstrate that glucose turnover in vivo is a function of the thyroid state being reduced in hypo- and considerably increased in hyperthyroidism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584186
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    Paper (German National Licenses)
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