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  • 1
    Electronic Resource
    Electronic Resource
    The interaction of solid surfaces in aqueous systems (1982)
    Springer
    Colloid & polymer science 260 (1982), S. 444-451 
    Details
    ISSN: 1435-1536
    Keywords: Surface forces ; surface hydration ; electrical double layer ; disjoining pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The interaction between two high-grade polished fused silica plates separated by a thin layer of aqueous LiCl, NaCl and KCl solution, respectively, was determined by means of a selfdeveloped method. Concerning the repulsion created by overlap of the electrical double layers excellent agreement with the DLVO theory down to separation of about 5 nm were found. For still smaller separations a relatively strong additional repulsion arises which according to experimental evidence might be assigned to the overlap of hydration layers emanating chiefly from the alkali metal halide ions adsorbed onto the silica surfaces. Our results agree well with those obtained by Israelachvili et al. and Pashley, who used mica sheets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01448150
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  • 2
    Electronic Resource
    Electronic Resource
    Differential response of human basophils and mast cells to recombinant chemokines (1995)
    Springer
    Annals of hematology 70 (1995), S. 251-258 
    Details
    ISSN: 1432-0584
    Keywords: Key words Human basophils ; Mast cells ; Recombinant chemokines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Chemokines are proinflammatory peptides regulating the functions of various hematopoietic cells. We have analyzed the effects of seven recombinant human (rh) chemokines (MCAF, RANTES, MIP-1α, MIP-1β, IL-8, GRO, and IP-10) on the growth and function of human basophils and mast cells. We found that MCAF, but not RANTES, MIP-1α, MIP-1β, IL-8, GRO, or IP-10, causes direct and dose-dependent histamine release from basophils (MCAF, 5 μg/ml: 26.9±3.4%; other chemokines: 〈5% of total histamine). An increased (2.1 to 3.5-fold) response to MCAF was obtained when basophils were preincubated with rh interleukin-3 (100 units/ml). Moreover, IL-3-primed basophils became responsive to physiologic concentrations (〈1 μg/ml) of MCAF, IL-8, and RANTES. None of the chemokines tested was able to induce histamine secretion in mast cells obtained from lung (n=2), skin (n=1), uterus (n=3), or tonsils (n=3), even when cells had been preincubated with the mast cell agonist SCF. The chemokines also failed to modulate the expression of activation antigens (CD11b/C3biR, CD25/IL-2Rβ, CD63, IL-3Rα, CD117/c-kit) on the mast cell line HMC-1 or the basophil cell line KU-812 and were unable to induce differentiation of basophils or mast cells in culture. Together, our results show that basophils respond to rhIL-8, rhMCAF, and rhRANTES and that, unlike human basophils, human mast cells are unresponsive to recombinant chemokines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01784044
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  • 3
    Electronic Resource
    Electronic Resource
    Differential modulation of chemosensitivity to alkylating agents and platinum compounds by DNA repair modulators in human lung cancer cell lines (2000)
    Springer
    Journal of cancer research and clinical oncology 126 (2000), S. 198-204 
    Details
    ISSN: 1432-1335
    Keywords: Key words DNA repair ; Resistance modifier ; Drug resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: Modulation of DNA repair represents one strategy to overcome cellular drug resistance to alkylating agents and platinum compounds. The effects of different known DNA repair modulators such as O 6-benzylguanine (6 μg/ml), fludarabine (25 ng/ml), aphidicolin (8.5 ng/ml), pentoxifylline (1.4 μg/ml) and methoxamine (12.4 μg/ml) on the cytotoxicity of mafosfamide, chlorambucil, 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU), cisplatin and carboplatin were tested in human lung cancer cell lines. Methods: Chemosensitivity of the human adenocarcinoma cell line MOR/P and the cisplatin-resistant subline MOR/CPR as well as the large-cell lung cancer cell line L23/P and its cisplatin-resistant counterpart L23/CPR were evaluated by the MTT colorimetric assay. Results: O 6-benzylguanine, an inhibitor of O 6-alkylguanine-DNA alkyltransferase, significantly sensitised MOR/P and MOR/CPR cells to the cytotoxic effect of BCNU. Fludarabine, methoxamine and aphidicolin did not change the chemosensitivity of the parental and cisplatin-resistant cell lines to any cytotoxic drug tested. Interestingly, O 6-benzylguanine enhanced the chemoresistance of parental and cisplatin-resistant cell lines to platinum compounds. Also, pentoxifylline increased resistance of the MOR cell lines to mafosfamide. Conclusions: Modulation of DNA repair elicits not only chemosensitisation but may also enhance cellular resistance to DNA-affine drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004320050033
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  • 4
    Electronic Resource
    Electronic Resource
    Signifikante Verlängerung des Überlebens durch komplette Resektion isolierter Lungenmetastasen nach Mammacarcinom (1998)
    Springer
    Der Chirurg 69 (1998), S. 735-740 
    Details
    ISSN: 1433-0385
    Keywords: Key words: Pulmonary metastases ; Breast cancer ; Resection ; Survival. ; Schlüsselwörter: Lungenmetastasen ; Mammacarcinom ; Metastasenresektion ; Überleben.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Zumindest ein Viertel aller Patienten mit Mammacarcinom kommen in ein metastasierendes Stadium. Ungeachtet der laufenden Adaptierung palliativer Therapiemodalitäten blieb das mittlere Überleben in diesem Stadium innerhalb von 25 Jahren unverändert (19–32 Monate nach Diagnose), und 95 % dieser Patientinnen starben an der Generalisierung des Malignoms. Das erste Therapieziel muß deshalb Schaffung und Erhaltung von Lebensqualität sein. Daneben hat sich die chirurgische Entfernung isolierter Lungenmetastasen nach anderen Malignomen als therapeutisches Konzept durchgesetzt. Berichtet wird von 3 epidemiologisch vergleichbaren Kollektiven aus insgesamt 125 Patientinnen unserer Abteilung mit isolierten Lungenmetastasen nach Mammacarcinom (Beobachtungszeitraum 1977–1997). Von 96 Patientinnen waren komplette Datensätze erhebbar, sodaß sie retrospektiv entsprechend der chirurgischen Therapie in 3 Gruppen stratifiziert werden konnten. 28 Patientinnen wurden komplett (K), 34 inkomplett (I) und 34 nicht (N) reseziert. Der Vergleich der 3 Therapiegruppen N, K und I untereinander hinsichtlich Tumorstadium, Histologie und Receptorstatus des Primärtumors, Anzahl der Metastasen und des tumorfreien Intervalls ergab keine statistisch signifikanten Unterschiede. Das mittlere Überleben der Gruppe K war mit 79 Monaten nach Resektion der Lungenmetastasen (5-Jahres-Überleben 80 %, 10-Jahres-Überleben 60 %) signifikant besser im Vergleich zu den Gruppen I und N (p 〈0,00002). Das mittlere Überleben der Gruppen I und N war mit 15,5 und respektive 9 Monaten nicht signifikant unterschiedlich. Das tumorfreie Intervall nach Operation des Primärtumors hatte auf die Prognose der Gruppe K keinen Einfluß, korrelierte aber mit dem Überleben in Gruppe N (R2 = 0,81). Die komplette Resektion isolierter Lungenmetastasen nach Mammacarcinom führt zu einer ausgeprägten Lebensverlängerung bei geringer Morbidität. Das Thoraxröntgen stellt daher einen unverzichtbaren Bestandteil des onkologischen Nachsorgeprogramms nach Mammacarcinom dar.
    Notes: Summary. At least 25 % of breast cancer patients develop distant metastases. In spite of increasingly sophisticated palliative therapies, the survival time of patients with metastasis did not appear to be significantly prolonged during the last 25 years (19–32 months following diagnosis) and 95 % of them die from metastatic disease. Therefore, it seems appropriate that the therapeutic risk/benefit ratio and impact on quality of life should be reassessed when asymptomatic patients are treated. Surgical treatment and pulmonary resection for metastatic disease has been proven a valuable therapeutic concept for a variety of malignancies. Three epidemiologically comparable collectives out of a total of 125 patients from our clinic were treated for isolated pulmonary metastasis following breast cancer (observation period: 1977–1997). Complete data sets could be established for 96 patients and were retrospectively analyzed following stratification into three groups according to their surgical therapy. Twenty-eight patients underwent complete resection (K), 34 had incomplete resections (I) and 34 had no surgical intervention for lung metastases (N). Comparison of the three therapy arms concerning stage, histology and receptor levels of the primary tumor, number of metastases, and the disease-free interval yielded no significant differences between groups K, I and N. Patients after complete resection of isolated lung metastases (group K) had a mean survival of 79 months (5-year survival 80 %, 10-year survival 60 %). This was significantly better than groups I and N (P 〈 0.00002). The mean survival of groups I and N was not significantly different (15.5 and 9 months respectively). The disease-free interval after operation of the primary tumor had no impact on the survival of group K, but showed a high correlation with the survival of group N (R 2 = 0.81). Complete resection of isolated pulmonary metastases from carcinoma of the breast results in marked prolongation of survival with a low morbidity rate. Hence, routine chest X-ray should be considered an indispensable part of the oncological aftercare in breast cancer patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050482
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  • 5
    Electronic Resource
    Electronic Resource
    Differential response of human basophils and mast cells to recombinant chemokines (1995)
    Springer
    Annals of hematology 70 (1995), S. 251-258 
    Details
    ISSN: 1432-0584
    Keywords: Human basophils ; Mast cells ; Recombinant chemokines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chemokines are proinflammatory peptides regulating the functions of various hematopoietic cells. We have analyzed the effects of seven recombinant human (rh) chemokines (MCAF, RANTES, MIP-1α, MIP-1β, IL-8, GRO, and IP-10) on the growth and function of human basophils and mast cells. We found that MCAF, but not RANTES, MlP-la, MIP-1β, IL-8, GRO, or IP-10, causes direct and dose-dependent histamine release from basophils (MCAF, 5 μg/ml: 26.9 ± 3.4%; other chemokines: 〈 5% of total histamine). An increased (2.1 to 3.5-fold) response to MCAF was obtained when basophils were preincubated with rh interleukin-3 (100 units/ml). Moreover, IL-3-primed basophils became responsive to physiologic concentrations (〈 1 μg/ml) of MCAF, IL-8, and RANTES. None of the chemokines tested was able to induce histamine secretion in mast cells obtained from lung (n=2), skin (n=1), uterus (n=3), or tonsils (n=3), even when cells had been preincubated with the mast cell agonist SCF. The chemokines also failed to modulate the expression of activation antigens (CD11b/C3biR, CD25/IL-2Rβ, CD63, IL-3Rα, CD117/c-kit) on the mast cell line HMC-1 or the basophil cell line KU-812 and were unable to induce differentiation of basophils or mast cells in culture. Together, our results show that basophils respond to rhIL-8, rhMCAF, and rhRANTES and that, unlike human basophils, human mast cells are unresponsive to recombinant chemokines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01784044
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  • 6
    Electronic Resource
    Electronic Resource
    Cellular aggregates in bone marrow cultures of patients with acute myeloid leukemia (1982)
    Springer
    Annals of hematology 44 (1982), S. 329-338 
    Details
    ISSN: 1432-0584
    Keywords: Acute myeloid leukemia ; Bone marrow culture ; Cellular aggregates ; Bone marrow stroma ; Adipocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We describe the incidence and morphology of cellular aggregates which may develop in 8 day bone marrow (BM) cultures of patients with acute myeloid leukemia (AML). Aggregates formed in at least one BM culture from 50% (20/39) of the AML group. They developed irrespective of the patient's status (i.e. stages M1–M4), FAB type, and presence of colony stimulating factor (CSF). All aggregates were composed of macrophages, plasma cells, and cells of the myelocyte series surrounding a core of adipocytes and collagen fibrils. The percentage of blasts and promyelocytes in the plated BM aspirate governed the final composition of the aggregate. Patients in Stages M3 or M4 with FAB types M1 or M2 formed aggregates with a high proportion of myelocytic cells; aggregates of all other AML patients were composed predominantly of macrophages and plasmacytes. Aggregates appeared to form as a result of attraction of cells in the medium toward the stroma cell core. Furthermore, the development of aggregates in the absence of exogenous CSF, suggested that stromal cells excreted a factor with CSF-like activity. The results indicate that cellular aggregates in AML-BM cultures reflect the important role of BM stroma in creating microenvironments which enhance the development of hemopoietic stem cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319916
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  • 7
    Electronic Resource
    Electronic Resource
    Cytotoxicity of adriamycin, idarubicin, and vincristine in acute myeloid leukemia: Chemosensitization by verapamil in relation to P-glycoprotein expression (1992)
    Springer
    Annals of hematology 65 (1992), S. 206-212 
    Details
    ISSN: 1432-0584
    Keywords: P-glycoprotein ; Drug resistance ; MTT assay ; Acute myeloid leukemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 4-day colorimetric tetrazolium dye (MTT) assay was used to assess the cytotoxicity of adriamycin (ADM), vincristine (VCR), and idarubicin (IDA) in blasts isolated from 37 patients with newly diagnosed and pretreated acute myeloid leukemia (AML). The effect of verapamil (VRP) as a chemosensitizer was studied in relation to the expression of the membrane efflux pump P-glycoprotein (PGP) as determined by a semiquantitative flow-cytometric procedure. A slight positive correlation was found between the fraction of cells expressing PGP and the ID50 values for ADM and VCR, but not between cellular PGP content and sensitivity to IDA. The overall data showed no significant sensitization effect of VRP. However, in specimens with more than 10% cells expressing PGP, 2μM VRP sensitized cells to ADM and VCR significantly. The median of sensitization ratios (SRs), i.e., the ratios of cytotoxic drug ID50 in the absence/presence of VRP, were 1.89 and 2.0, respectively. No sensitizing effect of VRP on the cytotoxicity of IDA was observed. Related to the clinical status, the median fraction of PGP-positive blasts was elevated fourfold in pretreated patients (n=16) in comparison to patients with de novo AML (n=19). No differences in ID50 values were observed between newly diagnosed and pretreated patients. However, SRs for ADM and VCR were higher in samples of pretreated patients compared with de novo AML. PGP-mediated cellular drug resistance may thus be circumvented in leukemic blasts by application of chemosensitizers or, potentially, alternative anthracyclines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01703946
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  • 8
    Electronic Resource
    Electronic Resource
    An experimental study of the behavior of transient isolated convection in a rigidly rotating fluid (1985)
    Springer
    Experiments in fluids 3 (1985), S. 17-23 
    Details
    ISSN: 1432-1114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The temperature field of starting thermal plumes were measured in a rotating annulus with various rotation rates and buoyancies. The experiments revealed many details of the internal structure of these convective phenomena and also significant horizontal displacements from their source. Measurements show an increase in the maximum temperature observed in the thermal caps with increasing rotation and a more rapid cooling of the buoyancy source.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00285266
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  • 9
    Electronic Resource
    Electronic Resource
    The role of inlet location on the dynamics of thin two-dimensional buoyant surface jets (1984)
    Springer
    Experiments in fluids 2 (1984), S. 137-142 
    Details
    ISSN: 1432-1114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The transition between the motion of a subsurface buoyant jet and a supersurface buoyant jet has been studied. Measurements indicate that the transition region is sharp and characterized by an intermediate regime where both a wall-hugging flow and the more standard outlet flow are present. The point of transition was found to exhibit significant hysteresis depending on whether the receiving pool height was increasing or decreasing with time. Measurements of the temperature field downstream show that the effects of the different regimes on the density stratification can persist for long distances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296429
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  • 10
    Electronic Resource
    Electronic Resource
    Isolierte Amyloidose der Hiluslymphknoten (1993)
    Springer
    Langenbeck's archives of surgery 378 (1993), S. 167-170 
    Details
    ISSN: 1435-2451
    Keywords: Thoracic surgery ; Mediastinal tumor ; Bronchogenic carcinoma ; Hilar lymph nodes ; Amyloidosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die isolierte hiläre Amyloidose des Mediastinums ohne pulmonale Beteiligung gehört zu den Raritäten der Thoraxchirurgie. Anhand eines Fallberichts wird die präoperativ schwierige Abgrenzung zum zentralen Bronchuskarzinom und zu mediastinalen Lymphomen demonstriert. Trotz umfangreicher bildgebender sowie bioptischer Diagnostik ergab erst die offene Biopsie mit anschließender Immunhistochemie das Vorliegen einer κ-Leichtkettenamyloidose der hilären Lymphknoten. Neben einer Literaturübersicht werden prä- und postoperative Diagnoseverfahren bei der Amyloidose diskutiert.
    Notes: Abstract Pseudotumoral mediastinal and pulmonary amyloidosis occur infrequently and may be confused with other tumors that are found more commonly in this region. Enlargement of hilar lymph nodes in the absence of pulmonary involvement is extremely rare. We report a case of nodular amyloidosis of the hilar lymph nodes that was studied using different diagnostic and radiologic methods. A previously healthy 79-year-old man presented with a large right hilar mass detected on routine chest roentgenography. The extensive mass behaved like a solid tumor and mimicked a bronchogenic carcinoma. At thoracotomy, frozen sections revealed the tumor to consist of kappa-light-chain amyloid. In light of the irresectibility of the tumor, thoracotomy was ended as open biopsy. Immunoelectrophoretic analyses of the plasma and urine showed no evidence of a paraprotein immunoglobulin or light chains. The patient was discharged without symptoms of disease. Different diagnostic procedures before and after surgery are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00184467
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