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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 57 (1982), S. 275-281 
    ISSN: 1432-0533
    Keywords: Spinal cord ; Conus medullaris ; Mixed chemodectoma and ganglioneuroma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Report of a 33-year-old man with a yearlong historory of low-back pain radiating into the left leg. Neurologic examination upon admission tto the hospital revealed a spinal compression syndrome at the lovel L5. Laminectomy at L4/5 revealed an encapsulated intradural tumor measuring 4×2.5×2.5 cm. The tumor was attached to the dorsal root L4 and extended downward to the conus region. Light and electron microscopy revealed features mostly consistent with a mixed chemodectoma and ganglioneuroma.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 318 (1982), S. 288-294 
    ISSN: 1432-1912
    Keywords: Mianserin ; Clonidine ; Desipramine ; Acetylcholine ; α2-Adrenoceptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The purpose of the present study was to characterize the effects of mianserin at α2-adrenoceptors. Firstly, the action of mianserin on postganglionic sympathetic fibres has been studied using the tachycardia induced by stimulation of the cardiac nerve in dogs. Mianserin increased this tachycardia, but could not prevent the inhibitory effect of clonidine in this model. However, an antagonistic effect of mianserin against clonidine was observed when animals were pretreated with desipramine. Secondly, mianserin antagonized the inhibitory effect of clonidine on the electrically stimulated guinea-pig ileum. In high concentrations, mianserin reduced both electrically and acetylcholine induced contractions. Thirdly, mianserin antagonised the sleep induced by clonidine in chickens. These results are consistent with α2-adrenoceptor blocking properties of mianserin in peripheral noradrenergic fibres in dogs, in cholinergic fibres in guinea-pig ileum and in the central nervous system in chickens.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Biopolymers 22 (1983), S. 241-246 
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 13C-, 1H-nmr, CD, and x-ray crystallography revealed β-turns of type III for Boc-Gly-L-Ala-Aib-OMe, Boc-L-Ala-Aib-L-Ala-OMe; the 310-helix for Boc-Aib-L-Ala-Aib-L-Ala-Aib-OMe; and antiparallel arranged α-helices for Boc-L-Ala-Aib-Ala-Aib-Ala-Glu(OBzl)-Ala-Aib-Ala-Aib-Ala-OMe. An N-terminal rigid α-helical segment is found in the polypeptide antibiotics alamethicin, suzukacillin, and trichotoxin. The α-helix dipole is essential for their voltage-dependent pore formation in lipid bilayer membranes, which is explained by a flip-flop gating mechanism based on dipole-dipole interactions of parallel and antiparallel arranged α-helices within oligomeric structures.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Propellants, Explosives, Pyrotechnics 9 (1984), S. 193-200 
    ISSN: 0721-3115
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The use of modified forms of the Rosenthal electrothermal equation to aid in the design of a capacitor discharge firing circuit for a specific detonator is described. The electrothermal parameters Cp and γ, representing the heat capacity of the bridge and the heat loss factor, respectively, were calculated from previously obtained firing data for the detonator. These calculations provided input to the design of a firing circuit utilizing electrolytic capacitors, which have a large value of electrical capacity but also a non-negligible internal resistance. Calculations were performed which (1) revealed the degrading effect on detonator initiation caused by too large a value of internal resistance, and (2) permitted selection of a particular capacitor that would allow reliable functioning of the detonator with initiation times of about 230 μs. The circuit was designed utilizing this capacitor, and in the experimental evaluation of the circuit the measured initiation times were compared with the calculated values. Good agreement between the two was documented, and the conclusion was reached that the detonator functioned reliably. The merits of the electrothermal analysis and the assumptions utilized therein relative to a vigorous heat transfer/reaction kinetics modeling of the flow of energy from the bridge into the explosive flash charge are discussed in detail.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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