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  • 1980-1984  (2)
  • Biochemistry  (1)
  • Shy-Drager syndrome  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 53 (1981), S. 333-336 
    ISSN: 1432-0533
    Keywords: Amacrine cell ; Tay-Sachs disease ; Ultrastructure ; Biochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ultrastructural study of the retina from a patient with Tay-Sachs disease disclosed that amacrine cells as well as ganglion cells were loaded with numerous membranous cytoplasmic bodies, suggesting an accumulation of GM2 ganglioside, whereas the horizontal cells, bipolar cells, and photoreceptor cells were intact. Chromatography of lipids from the retina showed a prominent spot of GM2 ganglioside. These facts suggest that lipid metabolism in amacrine cells may be different from that in other retinal cells.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0533
    Keywords: Onuf's nucleus ; Sphincter muscles ; ALS ; Shy-Drager syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The anterior sacral horns and external anal sphincter muscle were examined histologically with special reference to Onuf's nucleus in amyotrophic lateral sclerosis (ALS) and Shy-Drager syndrome. Onuf's nucleus and the external anal sphincter muscles were well preserved in ALS, but in Shy-Drager syndrome both structures showed marked degenerative changes. These findings suggest that Onuf's nucleus does not belong to the autonomic neurons, but to the motoneurons in anterior sacral horn, and it innervates the external sphincter muscles of the anus and urethra.
    Type of Medium: Electronic Resource
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