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  • 1
    Electronic Resource
    Electronic Resource
    Sorption kinetics in haemoperfusion columns. Part 1: estimation of mass-transfer parameters (1981)
    Springer
    Medical & biological engineering & computing 19 (1981), S. 617-626 
    Details
    ISSN: 1741-0444
    Keywords: Activated carbon ; Adsorption ; Catalysis ; Competitive adsorption ; Haemoperfusion ; Intraparticle diffusivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract Thein vitro measurement of adsorption isotherms and intraparticle diffusivities for three types of activated carbon and four exogenous and endogenous toxins is described. Complications due to the chemical breakdown of creatinine and paracetamol in the presence of activated carbon are discussed. Three methods are compared for the estimation of intraparticle diffusivity from the kinetic data. The simplest method is also used to reinterpret literature data comparing diffusivity values using plasma or HSA solution as opposed to buffer as the solvent. The adsorption isotherms and intraparticle diffusivities comprise the fundamental data used to validate the mass transfer model of a haemoperfusion column developed in Part 2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02442777
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Sorption kinetics in haemoperfusion columns. Part 2: modelling column performance (1981)
    Springer
    Medical & biological engineering & computing 19 (1981), S. 627-637 
    Details
    ISSN: 1741-0444
    Keywords: Haemodialysis ; Haemoperfusion ; Mass-transfer model ; Protein binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The relative influences of the normalised adsorption, mass transfer and hydrodynamic parameters on the performance of haemoperfusion columns are quantified using a lumped parameter, mass transfer model, validatedin vitro. The effects of patient pharmacokinetics and protein binding are then investigated using the model. In addition, the solution of the distributed parameter model of an adsorber column, at small times, is used to emphasise the role of the external diffusion resistance in determining column performance for both free and protein bound toxins. This rationale facilitates a logical comparison between haemoperfusion and haemodialysis on the basis of the controlling mass transfer mechanisms in each technique.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02442778
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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