ISSN:
1741-0444
Keywords:
Haemodialysis
;
Haemoperfusion
;
Mass-transfer model
;
Protein binding
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract The relative influences of the normalised adsorption, mass transfer and hydrodynamic parameters on the performance of haemoperfusion columns are quantified using a lumped parameter, mass transfer model, validatedin vitro. The effects of patient pharmacokinetics and protein binding are then investigated using the model. In addition, the solution of the distributed parameter model of an adsorber column, at small times, is used to emphasise the role of the external diffusion resistance in determining column performance for both free and protein bound toxins. This rationale facilitates a logical comparison between haemoperfusion and haemodialysis on the basis of the controlling mass transfer mechanisms in each technique.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02442778
