ISSN:
1432-0428
Keywords:
HDL-cholesterol
;
triglyceride
;
glucose tolerance
;
dietary therapy
;
weight loss
;
Type 2 diabetes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Intensive dietary therapy in 57 newly diagnosed Type 2 (non-insulin-dependent) diabetic patients led to an increase, compared with pre-treatment levels, in serum high density lipoprotein (HDL) cholesterol and the HDL/total cholesterol ratio after 3 and 6 months (0.05〈p〈0.1). The increase in HDL cholesterol was related to the degree of weight loss achieved. In 28 patients whose weight decreased by ⩾ 10% average body weight during the 6 months, HDL cholesterol rose from 1.22±0.06 to 1.36±0.06 mmol/1 (p〈0.001), whereas patients who lost less weight showed no significant increase in HDL cholesterol. The increase in mean serum HDL-cholesterol levels in female patients was associated with a mean weight reduction of 12.1% average body weight. Patients who were obese at diagnosis lost more weight during the study than non-obese patients (mean 13.2 versus 5.6% average body weight), and showed a significant increase in serum HDL-cholesterol levels. We conclude that intensive dietary therapy may lead to a less atherogenic lipid profile in Type 2 diabetes, particularly in patients who achieve a major weight reduction.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00257725
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