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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 96 (1989), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. We report five patients with phaeochromocytoma associated with pregnancy and review the 42 other cases reported in the literature from 1980 to 1987. The overall maternal mortality was 17% and the fetal loss 26%; antenatal diagnosis of phaeochromocytoma reduced the maternal mortality to zero and the fetal loss to 15%, but was made in only 53% of the patients. Although phaeochromocytoma is rare, a high index of clinical suspicion must be maintained and all those at risk investigated if earlier diagnosis and improved outcome are to be achieved. Once the diagnosis is confirmed, alpha-blockade is essential and beta-blockade may be required. CT scan or magnetic resonance imaging may be used to localize the tumour during the antenatal period. In the first and second trimesters, tumour resection has a good fetal outcome; in later pregnancy, delivery by elective caesarean section followed by tumour resection is recommended.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. A retrospective population study in Northern Ireland examined the benefits of centralized care in insulin-dependent diabetic pregnancies. In the 5 years 1979–1983, there were 139 250 deliveries in Northern Ireland and of these 221 pregnancies occurred in 187 insulin-dependent diabetic patients; 100 were managed entirely in peripheral maternity units, 61 were referred from a peripheral unit to the Royal Maternity Hospital, Belfast and 60 were managed entirely in this central referral hospital. The patients referred from the periphery had the worst past obstetric history with a combined perinatal mortality rate of 200 per 1000. During the study period the perinatal mortality rate was 107 for the referred pregnancies, 33 for those managed entirely in the peripheral units and 18 for those managed at the Royal Maternity Hospital. If those pregnancies terminated for fetal abnormality, and deaths beyond the perinatal period are included, the figures for total fetal loss were 15.5%, 5.5% and 7.1% respectively. Overall the major congenital malformation rate was 7.5%, and for the respective groups 6.5%, 3.0% and 13.0%. For the general population during the same period the perinatal mortality rate was 1.4% and the major congenital malformation rate was 2.5%. Thus it is suggested that only peripheral hospitals which can offer combined antenatal/endocrine care and with a neonatal intensive care unit should undertake the management of the pregnant diabetic.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 105 (1998), S. 0 
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We analysed a database of glycosylated haemoglobin (HbA1) in nondiabetic pregnant women to investigate the relation between glucose metabolism in the first and second trimesters and hypertensive complications of pregnancy. From a total of 1334 women, 13 had pre-existing hypertension, 225 developed gestational hypertension and 51 developed pre-eclampsia. At 28 weeks of gestation, the women who susequently developed gestational hypertension had a significantly higher mean HbAl than those who remained normotensive (6.33 vs 6.17%, P 〈 0.02). This difference remained significant after correcting for the effects of age and body mass index (regression coefficient 0.11, SE 0.06, P = 0.05). In contrast, there were no significant differences in HbAl between the women with pre-eclampsia and their normotensive counterparts. This provides indirect evidence to support our hypothesis that gestational hypertension is associated with insulin resistance but pre-eclampsia is not.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0428
    Keywords: Keywords Type 1 (insulin-dependent) diabetes mellitus ; epidemiology ; incidence ; childhood ; population density ; material deprivation ; overcrowding ; space-time clustering.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary During the period 1989–1994, 462 cases of insulin-dependent diabetes mellitus were registered among children from Northern Ireland aged under 15 years. The estimated completeness of the register was 98.8 % (95 % confidence interval (CI) 97.7 %, 99.9 %). A standardised rate of 19.6 (95 % CI 17.8, 21.4) per 100 000 person years was obtained, placing Northern Ireland near the top of the range of published incidence in the United Kingdom, with a rate close to that reported for Scotland. In an analysis based on 217 postcode sectors, areas with a high population density and the most material deprivation were observed to have the lowest incidence rates. After inclusion of population density in a Poisson regression analysis, the component of deprivation which was found to be most significant was household crowding. Relative to children living in areas of low population density, there was a reduced risk for children in medium (relative incidence 0.85 (95 % confidence limits CI 0.67,1.09)) and high (0.62 (95 %CI 0.48,0.80)) population density areas. Similarly, relative to children living in areas with low levels of household crowding, there was a reduced risk for children in medium (relative incidence 0.73 (95 % CI 0.58,0.93)) and high (0.67 (95 %CI 0.53,0.83)) levels of household crowding. Tests for space-time clustering at diagnosis and at birth were negative. A possible explanation for the differences in incidence rate observed in this study is that exposure to infections very early in childhood is a protective factor. Later infections may act as either initiators or promoters of diabetes, but the absence of space-time clustering suggests that no single specific infectious agent is responsible. [Diabetologia (1996) 39: 1063–1069]
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0428
    Keywords: Glucose tolerance test ; oral GTT ; cortisone GTT ; I.V. GTT ; pregnancy ; potential diabetes ; latent diabetes ; gestational diabetes ; foetal results ; perinatal mortality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les résultats des tests de tolérance au glucose dans un groupe sélectionné de 1718 patientes étudiées au cours de la trente-deuxième semaine de gestation sont comparés 1. principalement au poids maternel, et 2. en partie à l'âge maternel, à la maturité foetale et au poids foetal lors de la délivrance. Aucune préférence nette n'apparaît entre les trois tests, mais la valeur K (vitesse de disparition du glucose après glucose i.v.) est la plus sensible aux variables étudiées. Il n'est pas possible de prédire les conséquences sur le foetus à partir de l'information obtenue d'un test de tolérance au glucose effectué à la trente-deuxième semaine de gestation.
    Abstract: Zusammenfassung Die Glucosetoleranz-Tests bei einem ausgewählten Kollektiv von 1718 Frauen die in der 32. Schwangerschaftswoche durchgeführt wurden, werden a) vor allem durch das Gewicht der Mutter, b) z.T. aber auch durch ihr Alter, den Reifegrad des Foeten bei der Entbindung und sein Geburtsgewicht beeinflußt. Eindeutige Vorzüge ließen sich für keinen der 3 Tests ermitteln, doch scheint von den untersuchten Variablen der Wert (Glucose-Schwundrate nach i.v. Injektion) am empfindlichsten zu sein. Über das Schicksal des Foeten lassen sich an Hand eines in der 32. Schwangerschaftswoche durchgeführten Glucosetoleranz-Tests keine Voraussagen machen.
    Notes: Summary Results of glucose tolerance tests in a selected group of 1718 patients studied at the thirty-second week of gestation are related, a) mainly to the maternal weight, and b) in part to the maternal age, foetal maturity at delivery and foetal weight at delivery. No clear preference between the three tests emerges, but the K value (glucose disappearance rate after I.V. glucose) appears to be most sensitive to the variables studied. It is not possible to predict the foetal outcome with information obtained from a glucose tolerance test carried out at the thirty-second week of gestation.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0428
    Keywords: HDL-cholesterol ; triglyceride ; glucose tolerance ; dietary therapy ; weight loss ; Type 2 diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intensive dietary therapy in 57 newly diagnosed Type 2 (non-insulin-dependent) diabetic patients led to an increase, compared with pre-treatment levels, in serum high density lipoprotein (HDL) cholesterol and the HDL/total cholesterol ratio after 3 and 6 months (0.05〈p〈0.1). The increase in HDL cholesterol was related to the degree of weight loss achieved. In 28 patients whose weight decreased by ⩾ 10% average body weight during the 6 months, HDL cholesterol rose from 1.22±0.06 to 1.36±0.06 mmol/1 (p〈0.001), whereas patients who lost less weight showed no significant increase in HDL cholesterol. The increase in mean serum HDL-cholesterol levels in female patients was associated with a mean weight reduction of 12.1% average body weight. Patients who were obese at diagnosis lost more weight during the study than non-obese patients (mean 13.2 versus 5.6% average body weight), and showed a significant increase in serum HDL-cholesterol levels. We conclude that intensive dietary therapy may lead to a less atherogenic lipid profile in Type 2 diabetes, particularly in patients who achieve a major weight reduction.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0428
    Keywords: Emotional and academic achievement ; children of diabetic mothers ; Type 1 diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary No difference was found at paediatric assessment, or by a psychologically-based maternal and teacher questionnaire of the emotional state or academic achievement, between 123 children of Type 1 (insulin-dependent) diabetic mothers and 124 children of non-diabetic mothers. The groups were closely matched for maternal age, sex and position in sibship of the child, and age and home environment of the mother. The children of diabetic mothers had all been delivered before week 38 of gestation.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 29 (1986), S. 1-9 
    ISSN: 1432-0428
    Keywords: Diabetes in pregnancy ; perinatal loss ; total fetal loss
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The art of obstetrics is not a subject which is often discussed in the pages ofDiabetologia. However, as the care of the diabetic mother and her offspring is rightly an interdisciplinary responsibility between obstetrician, diabetologist and neonatologist, it is important that each has s. close understanding of the various problems. Dr. M.I. Drury (Dublin), speaking as an internist, raises a question on the optimum time and method of delivery of the baby; this has more than purely obstetrical implications. Drs. L. Mølsted-Pedersen (Copenhagen) and C. Kühl (Copenhagen and Klampenborg), obstetrician and internist from the longest-established joint obstetric/diabetic service in the world, present a Scandinavian view on the management of regnancy. Both centres have distinguished records in the management of diabetic pregnancy. The different viewpoints in Denmark and in Ireland are clear — in Copenhagen, therapeutic abortion is practiced in a pregnancy at risk of severe congenital malformation; in Dublin it is not. Dr. Drury quotes a perinatal loss of 13 of 285 pregnancies (4.5%) in the past 5 years, but does not include the recognised spontaneous abortions which, on his overall figures, are about 10% of conceptions. Dr. Molsted-Pedersen reports a perinatal loss of 3 of 201 infants (1.5%), excluding 17 spontaneous and 9 induced abortions. If these 9 aborted pregnancies, which were performed due to a risk of severe congenital malformation, were included as fatalities, the Copenhagen figure would be 12 of 210 (5.5%). Of course, we do not know if all those 9 fetuses were affected. The spontaneous abortion rate was 17 of 223 (8.0%). Thus, if total fetal loss is taken as the index, there appears to be little difference between the two centres. The clinical controversy on the timing and method of birth in the different centres will continue - pundits can be conservative as well as radical, and, as Dr. Drury remarks, the truth probably lies somewhere in between. The bottom line in reports on the management of diabetes in pregnancy used to be the perinatal mortality (from 28 weeks gestation to the end of the first week of life). With the continuing improvement in neonatal care, more babies who would have died during the perinatal period are surviving beyond the seventh day of life. As a result, their subsequent deaths are not recorded in many publications. Even greater emphasis will fall on the quality of life for those infants surviving with a major congenital abnormality (heart and neural tube defect) which produces profound childhood morbidity. Prevention of these congenital abnormalities is the most important aim of pre- and early conceptional care of the diabetic mother. Both centres which report their recent results in this issue would agree that there has been an improvement even in the past 5 years — the problem is to define exactly which developments account for the change for the better, and which previously-trusted techniques can safely be allowed to fall by the wayside.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 4 (1968), S. 229-231 
    ISSN: 1432-0428
    Keywords: Diabetes ; Circadian ; Adrenal ; Rhythm ; Hypoglycaemia ; 11-OH ; Corticosteroid ; Insulin Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Le rythme circadien de la sécrétion corticosurrénale de 18 diabétiques était normal, comme on a pu en juger par les taux plasmatiques en série des 11-OH-corticostéroïdes. Des épisodes d'hypoglycémie modérée ont provoqué une augmentation des 11-OH-corticostéroïdes du plasma chez 12 patients diabétiques sous thérapeutique insulinique.
    Abstract: Zusammenfassung Bei 18 Diabetikern wurde durch Serienbestimmung der Plasma-11-OH-Corticosteroidspiegel ein normaler Tagesrhythmus der Nebennierenrinden-Sekretion gefunden. Leichte Hypoglykämien bewirkten einen Anstieg der 11-OH-Corticosteroidspiegel im Plasma bei 12 insulinbehandelten Diabetikern.
    Notes: Summary The circadian rhythm of adrenocortical secretion in 18 diabetic subjects was normal as judged by serial plasma 11-OH-corticosteroid levels. Mild episodes of hypoglycaemia induced a rise in the plasma 11-OH-corticosteroid in 12 diabetic patients on insulin therapy.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0428
    Keywords: Keywords Diabetes mellitus ; diagnosis ; oral glucose tolerance test ; fasting plasma glucose ; 2-h plasma glucose ; haemoglobin A1c ; retinopathy ; nephropathy ; complications.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The current classification and diagnostic criteria for diabetes mellitus were introduced by the United States National Data Group in 1979 and endorsed by the World Health Organization in 1980, with modifications in 1985 and 1994. The criteria, chosen to reflect the risk of complications, were the synthesis of considerable thought and expertise and represented a consensus which, it was hoped, would prove helpful to all those involved with diabetes – practising clinician, research scientist and epidemiologist alike. The inconvenience, variability and nonphysiological nature of the oral glucose tolerance test (OGTT) are well-recognised. In spite of these limitations the 2-h post-load plasma glucose has remained the standard against which all other tests have been evaluated. This article reviews the original justification for the OGTT, and in the light of more recent epidemiological research seeks to place the current diagnostic criteria for diabetes into a pathophysiological, diagnostic and prognostic perspective. [Diabetologia (1997) 40: 247–255]
    Type of Medium: Electronic Resource
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