ISSN:
0170-2041
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
Syntheses of Peptide Alkaloids, IX. - Amino Acids and Peptides, XLVI. - Total Synthesis of Mucronin BThe total synthesis of hte cyclopeptide alkaloid mucronin B (5), an ansapeptide with a 12-membered “handle” is described. Key steps are the preparation of hte N-methylamino acid 16 via phosphonate condensation followed by enantioselective hydrogenation and ring closure of hte linear educts 24a + 24b, which is achieved by catalytic hydrogenation and affords the ring compounds 25a + 25b.
Notes:
Es wird die Totalsynthese des Cyclopeptidalkaloids Mucronin B (5), eines Ansapeptids mit 12gliedrigem Henkel, beschrieben. Charakteristische Stufen sind der Aufbau der N-Methylaminosäure 16, durch Phosphonat-Kondensation mit enantioselektiver Hydrierung und der hydrierende Ringschluß des linearen Edukts 24a + 24b zum Cyclus 25a + 25b.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.198419840616
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