Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    β-adrenoceptor blockade and migraine (1982)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 2 (1982), S. 0 
    Details
    ISSN: 1468-2982
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Except for propranolol, no other b-blocker has been studied thoroughly in the prophylaxis of migraine. Of those studied, propranolol, atenolol and timolol were shown to be useful in double-blind clinical trials. The mode, or even the site of action of these drugs is unknown. Possible mechanisms of action are peripheral vascular effects, a central action, 5-HT antagonism, an anxiolytic effect and a multifactorial action. The only common property of the successful drugs is lack of partial agonist activity and their profiles do not fully support any of the above hypotheses. Trials of drugs in the prophylaxis of migraine have in general been unsatisfactory due to the difficulty in controlling many variables. b-blockers with differing properties offer an opportunity to define the properties necessary for anti-migraine activity and perhaps shed light on the pathogenesis of migraine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1468-2982.1982.0201033.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Experiments to Assess the Hydraulic Efficiency of Well Screens (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Ground water 21 (1983), S. 0 
    Details
    ISSN: 1745-6584
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geosciences
    Notes: The hydraulic properties of commercial well screens were investigated to determine which screen design features affected head loss. The test program began with laboratory experiments and continued as a field-scale experiment with the installation of a well field in the Thames Valley Gravel Aquifer.The laboratory experiments indicated that, for all practical purposes, the head loss attributable to all of the screens tested was negligible. The experimental head loss, however, did vary from screen to screen, particularly at high intake velocities, and the screens could be ranked on the basis of their hydraulic efficiencies. This efficiency hierarchy is explained tentatively in terms of the screen construction methods and slot geometry. The field experiments showed that the hydraulic performance of all well screens is independent of screen design provided that the open area of the screen is above about 10%. The field experiments also indicated that the development capacity of a screen in a gravel aquifer is not wholly dependent on screen design, but that progressive development does increase the hydraulic efficiency of a well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1745-6584.1983.tb00722.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Components of A Jungian Theoretical Orientation (1984)
    Oxford, UK : Blackwell Publishing
    The @journal of analytical psychology 29 (1984), S. 0 
    Details
    ISSN: 1468-5922
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Psychology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1465-5922.1984.00067.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Carbon cycle changes of the Zechstein Sea: isotopic transition zone in the Marl Slate (1982)
    [s.l.] : Nature Publishing Group
    Nature 297 (1982), S. 389-390 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] On the basis of measurements of carbon isotopes on rocks of various ages, early models assumed that the mean S13C (carbonate) values were constant3"6. In recent years, however, descriptions of secular variation of S13C values in carbonate rocks during the Mesozoic7'8 and Cenozoic9*10 have ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/297389a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    The bioavailability of oral intermediate-dose methotrexate (1984)
    Springer
    Cancer chemotherapy and pharmacology 13 (1984), S. 91-94 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The oral bioavailability of methotrexate is variable and may be dose-dependent. The absorption of ‘interval’ oral methotrexate, which is given between cycles of chemotherapy, is unknown. The bioavailability of oral methotrexate has been studied in eight patients, acting as their own controls, to assess the effect of subdivision of the dose, the formulation, and the timing of the methotrexate within the chemotherapy cycle. The mean bioavailability for all the oral methods of administration was 28.2%±3.7% compared with the same dose given IV. Absorption was uninfluenced by subdivision of the dose, liquid or tablet formulation, or administration on day 1 or day 10 of the chemotherapy cycle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257121
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    The efficiency of protective gloves used in the handling of cytotoxic drugs (1984)
    Springer
    Cancer chemotherapy and pharmacology 12 (1984), S. 151-153 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A range of clinical and industrial gloves have been evaluated to determine their ability to exclude penetration by cytotoxic drugs. Radiolabelled cyclophosphamide, methotrexate, daunomycin, cytosine arabinoside, and vincristine sulphate were studied in an equilibrium dialysis system in which the glove material was used as the dialysis membrane. The thicker gloves were the most effective, but very little drug crossed any of the gloves tested under laboratory conditions. Further studies to evaluate gloves in conditions of clinical use are now needed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256536
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    The effect of a new antiarrhythmic agent, flecainide acetate, on systolic time intervals (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 13-18 
    Details
    ISSN: 1432-1041
    Keywords: flecainide ; antiarrhythmic agent ; systolic time intervals ; heart functions ; conduction delay ; myocardial contractility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We investigated the effect of flecainide on systolic time intervals in 6 healthy subjects. A randomized, double blind, cross-over study was designed using flecainide (2 mg/kg), propranolol (0.2 mg/kg) or saline. In comparison with placebo, flecainide increased heart rate, diastolic BP, QT-Index, QS2-Index, PEP, and reduced LVET-Index (p〈0.05). It caused a significant increase in PR interval, QRS duration, and PEP/LVET (p〈0.01). Propranolol, compared with placebo, decreased heart rate and systolic BP (p〈0.05). It increased PR interval, PEP, and PEP/LVET ratio (p〈0.05). In comparison with propranolol, flecainide increased heart rate and QRS duration (p〈0.01, p〈0.001 respectively). It increased diastolic BP, PR interval, QS2-Index, PEP, and PEP/LVET ratio, and decreased LVET-Index (p〈0.05). These changes in STI induced by flecainide may be produced by depression of myocardial contractility. Intraventricular conduction delay may be an additional contributing factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544007
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Preliminary clinical pharmacological studies of S3341, a new hypotensive agent, and comparison with clonidine in normal males (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 281-286 
    Details
    ISSN: 1432-1041
    Keywords: S3341 ; clonidine ; hypotensive drug ; side-effects ; cardiovascular effects ; alpha2-receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary S3341, a new hypotensive agent which binds to alpha2-receptors in animal brain preparations, was studied in normal healthy male volunteers. A dose ranging study with 15 and 25 µg/kg of S3341 was performed in a double blind, placebo controlled randomised and balanced manner with 3 subjects. A decrease or BP without noticeable sedation (assessed by visual analogue scales) was seen. One, 2 mg of S3341, 0.1 and 0.2 mg of clonidine were then compared in a double blind, placebo controlled, randomised and balanced manner in 10 subjects. BP, heart rate, systolic time intervals (STI), critical flicker frequency, choice reaction time, pursuit rotor, stimulated salivary volume, and dryness of mouth and sedation with visual analogue scales, were measured at 0, 1.5, 3.0, 4.5 and 6.0 h after drug administration. The relationship between decreases in BP and sedation was assessed by linear regression analysis, with the former as the independent (predictor) response and the latter as the dependent (response) variate. Both drugs produced a similar decrease of BP which was significantly different from placebo. Changes in psychomotor function tests were not significant. Both drugs produced dryness of mouth and sedation which were significantly different from placebo but changes were less with S3341. Clonidine showed a significantly steeper slope than S3341 in the relationship between decreases in BP and sedation. This must be interpreted with caution as there was wide variation in the correlation between decreases in BP and sedation, but it may be possible to achieve lesser sedation with S3341.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542160
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Effects of chlorpromazine and other drugs acting on the central nervous system on human sperm motility (1982)
    Springer
    European journal of clinical pharmacology 22 (1982), S. 413-416 
    Details
    ISSN: 1432-1041
    Keywords: chlorpromazine ; sperm motility ; central nervous system depressant ; caffeine ; membrane stabilizing effect ; fertility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The in vitro effects of chlorpromazine, diazepam, phenytoin and phenobarbitone on human sperm motility were investigated. Only chlorpromazine inhibits human sperm motility and the concentration which decreases sperm motility to 50% of control is 0.22 mM. Caffeine can shift the dose-response curve of chlorpromazine-inhibited sperm motility to right. We support the hypothesis that chlorpromazine acts on the cellular membrane but consider the inhibition of sperm motility an unlikely cause of decreased fertility in chlorpromazine treated patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542545
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    A double blind trial of UK-38,485, an orally active thromboxane synthetase inhibitor, in the treatment of Raynaud's syndrome (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 61-65 
    Details
    ISSN: 1432-1041
    Keywords: thromboxane synthetase inhibitors ; Raynaud's syndrome ; systemic sclerosis ; UK-38,485 ; ischaemic attacks ; red blood cell rheology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Ten patients with moderate to severe Raynaud's syndrome were recruited into a four week randomised double blind crossover study to compare the efficacy of UK-38,485 50 mg, a new thromboxane synthetase inhibitor with that of placebo. With the doses used there was no significant difference between the two treatment periods in the number, severity and duration of ischaemic attacks, the mean hand temperatures, forearm and digital blood flow and red blood cell rheology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553156
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...