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  • 1
    Electronic Resource
    Electronic Resource
    PULMONARY CIRCULATION IN PORTAL HYPERTENSION (1970)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 170 (1970), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1970.tb37021.x
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  • 2
    Electronic Resource
    Electronic Resource
    Atopic dermatitis and congenital deafness (1978)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 99 (1978), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In a family with perceptive, non-progressive hearing loss several of the members suffered from atopic dermatitis. The proband had a severe atopic dermatitis and an extremely high IgE value. Some of the family members suffered from atopic dermatitis, others from deafness, and some from both diseases. The co-existence of these two disorders has been previously described in two families. Atopic dermatitis and perceptive, non-progressive congenital deafness might be genetically associated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1978.tb02004.x
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  • 3
    Electronic Resource
    Electronic Resource
    Allergic contact dermatitis from croton (Codiaeum) (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Contact dermatitis 3 (1977), S. 0 
    Details
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0536.1977.tb03609.x
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  • 4
    Electronic Resource
    Electronic Resource
    Zur Frage des Nachweises von reinem Para-Stickstoff (1930)
    Springer
    Naturwissenschaften 18 (1930), S. 282-283 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01495217
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  • 5
    Electronic Resource
    Electronic Resource
    Allgemeine Therapie (1934)
    Springer
    Journal of cancer research and clinical oncology 40 (1934), S. 56-60 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01620132
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  • 6
    Electronic Resource
    Electronic Resource
    Alkylierung der DNA verschiedener Tumorzellarten nach in vivo Gabe von Cyclophosphamid (1973)
    Springer
    Journal of cancer research and clinical oncology 80 (1973), S. 239-245 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Dosisabhängigkeiten der Hemmung der Zellvermehrung und der Alkylierbarkeit der DNA nach in vivo-Gabe von Cyclophosphamid wurden bei drei verschiedenen Tumorzellstämmen gemessen. Der Unterschied zwischen dem Ehrlich-Ascitescarcinom (EAC) und dem Yoshida-Ascitessarkom (YAS) hinsichtlich der Alkylierbarkeit der DNA bei einer bestimmten Cyclophosphamiddosis ist sehr gering, obwohl die Dosis, die zu einer definierten Hemmung der Zellvermehrung führt, bei EAC-Zellen 120 mal größer ist als bei YAS-Zellen. Beim Vergleich eines gegen Cyclophosphamid resistenten Ehrlich-Ascitescarcinoms (EAC res) mit dem EAC ergibt sich eine etwa auf die Hälfte herabgesetzte Alkylierbarkeit der DNA für die EAC res-Zellen. Jedoch ist die für die Hemmung der Zellvermehrung erforderliche Dosis bei den EAC res-Zellen mehr als 20 mal so groß wie bei den EAC-Zellen. Die Annahme, daß die Alkylierung der DNA ursächlich für die cytostatische Wirkung der alkylierenden Substanzen ist, findet durch diese Beobachtungen keine Bestätigung.
    Notes: Summary Three different tumor cell lines have been compared with respect to the effects of in vivo application of cyclophosphamide on cell growth and on DNA alkylation. Minimal differences have been observed with respect to alkylation of DNA between Ehrlich ascites carcinoma (EAC) cells and Yoshida ascites sarcoma (YAS) cells, whereas YAS cells are 120 times more sensitive to cyclophosphamide than EAC cells as far as cell growth is concerned. Alkylation of DNA of cyclophosphamide resistant EAC cells has been decreased by nearly 50% compared with non-resistant EAC cells. In order to obtain similar effects on cell growth, however, more than the 20-fold dose of cyclophosphamide has been required for the resistant EAC cells. These results do not confirm the assumption that the cytostatic effect of alkylating agents is related to alkylation of DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00284324
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  • 7
    Electronic Resource
    Electronic Resource
    Contractile responses to direct stimulation of frog slow muscle fibres before and after denervation (1979)
    Springer
    Pflügers Archiv 382 (1979), S. 43-50 
    Details
    ISSN: 1432-2013
    Keywords: Slow fibres ; Contractile responses ; Effect of denervation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 1. The contractile responses of single slow muscle fibres were investigated under isometric conditions. The fibres were isolated from normal and denervated iliofibularis muscles ofRana temporaria. Direct stimulation was achieved by external application of electrical pulses or depolarizing solutions (40 mM K and acetylcholine 10\t-6 g/ml). 2. Upon electrical stimulation normal slow fibres developed contractions whose amplitude increased steadily with the strength of the pulses. These contractions did not exceed 0.22 kg/cm2, and their rates of rise and fall were approximately 1/6 of those observed in twitch fibres. During pulses of several 100 ms duration the tension continued to rise slowly until the end of the pulses. Application of 40 mM K or acetylcholine resulted in contractures which reached maximum values of 1.71 and 1.87 kg/cm2, respectively, after less than 1 min; little relaxation occurred during the following minutes. 3. The responses of slow fibres denervated for 9−76 days differed in several respects from those of normal slow fibres. a) The contractions elicited by electrical stimulation became faster but their amplitude decreased; the relationship between tension and pulse strength remained, however, essentially unchanged. b) Small and short contractions could be observed during and at the end of stimulating current pulses. Their amplitude was independent of the amplitude and duration of the stimuli; they were blocked by tetrodotoxin and must be attributed to action potentials. c) The ability to develop and maintain tension was reduced. Maximum values of K- and acetylcholine contractures were generally only 50% of those observed in normal slow fibres. Maintenance of tension was markedly reduced in some fibres, less so in others. 4. It is concluded that incorporation of Na channels into its membrane does not transform the slow fibre into a type of fibre which resembles a twitch fibre.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585902
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  • 8
    Electronic Resource
    Electronic Resource
    Effect of nerve length and temperature on the induction of action potentials in denervated slow muscle fibres of the frog (1977)
    Springer
    Pflügers Archiv 372 (1977), S. 17-22 
    Details
    ISSN: 1432-2013
    Keywords: Slow muscle fibres ; Action potential ; Nerve stump ; Temperature
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A. Pyriformis and extensor longus digiti IV muscles of Rana temporaria were denervated by cutting the sciatic or peroneal nerve at various distances from the muscles. Slow fibres were identified by their membrane time constants, and examined for their ability to produce action potentials in response to intracellularly applied current pulses. B. The slow muscle fibres acquired the ability to generate action potentials several days after denervation. The duration of this latent period depended on the length of the peripheral nerve stump, and on the temperature at which the frogs were kept after the operation. C. At 18°C the latent period increased by 0.36 days per mm of sciatic nerve stump. At 11.5° C the corresponding value was 0.7 days/mm. The effect of length of the peroneal nerve was smaller than that of the sciatic nerve. D. It is suggested that the peripheral nerve stump serves as a reservoir of ‘trophic’ material which is transported towards the slow fibres at a rate of 2.8 mm/day (at 18° C) and seems to block the formation of Na channels. TheQ 10 value of this transport system would be 2.7.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00582201
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  • 9
    Electronic Resource
    Electronic Resource
    Changes in envelope permeability during chloroplast development (1976)
    Springer
    Planta 129 (1976), S. 69-73 
    Details
    ISSN: 1432-2048
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The permeability of the plastid envelope during the development of Avena sativa plastids was investigated by light scattering and uptake of various labelled compounds (malate, succinate, glutamate, α-ketoglutarate, citrate, glycine, sucrose). The results presented show that a primary event during greening is a change in permeability, thereby allowing an increased transport of metabolites across the membranes of very early etio-chloroplast stages. The results are discussed in view of an adaption of the plastid envelope permeability to the changing requirements of externally synthesized precursors and intermediates during development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00390916
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  • 10
    Electronic Resource
    Electronic Resource
    Skeletal findings in homocystinuria: A collaborative study (1973)
    Springer
    Pediatric radiology 1 (1973), S. 12-23 
    Details
    ISSN: 1432-1998
    Keywords: Spondylo-epi-metaphyseal osteodysplasia ; osteoporosis ; avascular necrosis ; capitate enlargement ; lunate retardation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a collaborative study from 7 European medical centres the radiographs of 24 patients with homocystinuria from 17 families were examined. The incidence and severity of bone manifestations were recorded. Homocystinuria may well be characterised as a spondylo-epimetaphyseal osteodysplasia because the main pathological changes occur in the vertebral column and in the epi-metaphyscal growth areas. Demineralisation was the leading symptom in the present series in all skeletal parts affected. In most instances careful examination of the radiographs enables the diagnosis of homocystinuria to be made radiologically. The pathogenesis and characteristic pattern of distribution of the osteoporosis require elucidation by further histological and biochemical investigation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00972819
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