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  • 1975-1979  (4)
  • 1960-1964
  • 1930-1934
  • incretin  (2)
  • Chemotaxis  (1)
  • Granulozytentransfusion  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The clinical efficacy of granulocyte transfusions: Studies on the oral cavity (1977)
    Springer
    Annals of hematology 35 (1977), S. 405-414 
    Details
    ISSN: 1432-0584
    Keywords: Granulocyte transfusion ; Orogranulocytes ; Granulozytentransfusion ; Orogranulozyten
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Patienten mit schwerer Granulozytopenie unterschiedlicher Genese erhielten Granulozytentransfusionen. Als in vivo Parameter für die Viabilität von transfundierten Granulozyten wurden die Fähigkeit zur Migration in die Mundhöhle (“Orogranulozyten”) und zur Phagozytose untersucht. Zwischen Granulozyten, die mit dem kontinuierlichen Blutzellseparator und Granulozyten, die durch Filtrationsleukapherese gewonnen worden waren, bestand kein Unterschied. Unter Granulozytentransfusionen bildeten sich Schleimhautulcera im Bereich der Mundhöhle zurück und heilten ab. Waren Schleimhautulcera vorhanden, kam es nach Granulozytentransfusion zu einem Anstieg der Orogranulozyten (OG). Zwischen der Granulozytenzahl im peripheren Blut und der Anzahl der Orogranulozyten bestand eine statistisch signifikante Beziehung. Als Kontrolle wurden Gesunde mit intaktem Gebiß, Zahnlose mit normalem Blutbild und eine Patientin mit akuter Agranulozytose untersucht.
    Notes: Summary Patients with severe granulocytopenia of different origin received granulocyte transfusions. The migration and phagocytic ability of the transfused granulocytes in the oral cavity (“orogranulocytes”) served as a parameter for measuring the viability of the granulocytes in vivo. There was no difference between granulocytes collected by continuous flow centrifugation and those collected by filtration leukapheresis. Under the influence of the transfusion treatment mucous membrane ulcers (MMU) subsided and healed. Where ulcers were present the number of orogranulocytes (OG) increased after granulocyte transfusion. In addition there was a significant correlation between the number of granulocytes in the peripheral blood and the number of orogranulocytes. As a control, orogranulocytes were studied in a group of healthy persons with intact teeth, toothless persons with normal blood counts and one patient with an acute agranulocytosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00996627
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Response of gastric inhibitory polypeptide (GIF) to test meal in chronic pancreatitis — Relationship to endocrine and exocrine insufficiency (1976)
    Springer
    Diabetologia 12 (1976), S. 609-612 
    Details
    ISSN: 1432-0428
    Keywords: GIP ; gastrin ; insulin ; incretin ; chronic pancreatitis ; test meal ; malassimilation of fat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-nine patients with chronic pancreatitis had a significantly greater IR-GIP response to a test meal than 15 controls. This increased response was not related to the degree of steatorrhoea or glucose intolerance. It was most marked in a group of patients with moderately impaired IRI release and medium steatorrhoea. From this is concluded that the IR-GIP response to a test meal is determined by at least two factors: 1. feedback control via insulin secretion, 2. assimilation of fat. In chronic pancreatitis endocrine insufficiency may induce an exaggerated GIP response and severe exocrine insufficiency may prevent fat induced GIP release. Gastrin is not involved in the different GIP response in patients with chronic pancreatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01220638
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Gastric inhibitory polypeptide (GIP), gastrin and insulin: Response to test meal in coeliac disease and after duodeno-pancreatectomy (1976)
    Springer
    Diabetologia 12 (1976), S. 279-286 
    Details
    ISSN: 1432-0428
    Keywords: GIP ; gastrin ; insulin ; incretin ; coeliac disease ; duodeno-pancreatectomy ; chronic pancreatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The response of serum immunoreactive gastric inhibitory polypeptide (IR-GIP), gastrin (IRG) and insulin (IRI) to a mixed standard meal was measured in 15 controls, 6 patients with coeliac disease, 26 patients with chronic pancreatitis and 6 patients with chronic pancreatitis and partial duodenopancreatectomy (Whipple's procedure). Serum levels of IR-GIP, IRG and IRI were significantly reduced in patients with coeliac disease. The serum glucose increase was significantly smaller only during the first hour after the meal. Since small intestinal GIP- and G-cells are situated mainly in the glands of duodenal and jejunal mucosa their absolute number is not significantly reduced in coeliac disease. It is suggested that the release of IR-GIP and duodenal IRG is influenced by the rate of absorption of nutrients. In patients with chronic pancreatitis the IR-GIP release is significantly greater than in controls, the IRG release normal and the IRI response delayed. After Whipple's procedure the IR-GIP response is increased significantly while the IRG secretion is abolished. This demonstrates that the duodenum is not necessary for GIP release and that pancreatic and jejunal gastrin are without clinical significance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422096
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    High granulocyte yield with a simple method of filtration leukapheresis (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 409-414 
    Details
    ISSN: 1432-1440
    Keywords: Filtrationsleukapherese ; Granulozyten ; Phagozytose ; Intrazelluläre Keimabtötung ; Chemotaxis ; Filtration leukapheresis ; Granulocytes ; Phagocytosis ; Intracellular microbicidal activity ; Chemotaxis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A simple continuous filtration leukapheresis has been devised whereby two Leuko-Pak filters can be charged and eluted within 5 h with approximately 12 l of blood in a closed system of tubes. Blood flows by means of gravity without the use of pumps. Without premedication with prednisolone the average yield from 10 donors was 3.66×1010 granulocytes per leukapheresis and after premedication with 150 mg prednisolone orally it was 6.44×1010 granulocytes per leukapheresis. The in vitro function of filter granulocytes was not reduced even after premedication with prednisolone. In comparison with leukapheresis by blood cell separators this modified method of filtration leukapheresis offers the following advantages: 1) the granulocyte yield per litre of whole blood processed is higher, 2) technical assistants in a blood-bank can carry out the method on several donors simultaneously, 3) the method is more economical than leukapheresis by blood cell separators.
    Notes: Zusammenfassung Es wurde eine einfache kontinuierliche Filtrationsleukapherese (FL) zur Gewinnung von Granulozyten entwickelt, mit der zwei Leuko-Pak-Filter innerhalb von 5 h mit etwa 12 Liter Blut im geschlossenen System beschickt und eluiert werden können. Der Blutfluß erfolgt dabei ohne Pumpe allein durch Schwerkraft. Die durchschnittliche Ausbeute betrug bei 10 Spendern ohne Vorbehandlung mit Prednisolon 3,66×1010 Granulozyten pro Leukapherese, nach Vorbehandlung mit 150 mg Prednisolon p.o. 6,44×1010 Granulozyten pro Leukapherese. In vitro-Tests zeigten, auch nach Gabe von Prednisolon, keine Einschränkung der Funktionsfähigkeit der Filtergranulozyten. Die vorliegende modifizierte Form der FL hat im Vergleich zur Leukapherese durch Blutzellseparatoren folgende Vorteile: 1. Die Granulozytenausbeute bezogen auf Liter separiertes Vollblut ist höher. 2. Die Methode kann durch Hilfspersonal in einer Blutbank an mehreren Spendern gleichzeitig durchgeführt werden und sie ist 3. wirtschaftlicher als die Leukapherese mit Blutzellseparatoren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477296
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    Paper (German National Licenses)
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