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  • 1975-1979  (6)
  • 1915-1919
  • Hybrids, linear combination of ∼  (3)
  • Isoprenaline  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Inhibitory effect of tyramine-induced release of catecholamines on renin secretion (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 303 (1978), S. 139-144 
    Details
    ISSN: 1432-1912
    Keywords: α-Adrenoceptors ; Renin ; Isoprenaline ; Tyramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of the indirect sympathomimetic agent tyramine on the isoprenaline-induced increase in plasma renin concentration was investigated in conscious rats. Tyramine caused a dose-dependent decrease in the isoprenaline-induced elevation of plasma renin concentration. Pretreatment of the rats with reserpine abolished this effect of tyramine, indicating that tyramine released catecholamines which acted on the inhibitory adrenoceptors. Pretreatment with phenoxybenzamine, an α-adrenoceptor antagonist, also abolished the inhibitory effect of tyramine on renin release, indicating that α-adrenoceptors mediated the observed inhibition of renin release. In rats with chronically denervated kidneys tyramine did not inhibit renin release. It is concluded that catecholamines which are released from renal sympathetic nerve endings can suppress renin release by activating α-adrenoceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508059
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Linear combination of hybrid orbitals: Acyclic alkanes (1977)
    Springer
    Theoretical chemistry accounts 43 (1977), S. 287-297 
    Details
    ISSN: 1432-2234
    Keywords: Hybrids, linear combination of ∼ ; Saturated organic compounds, MO treatment of ∼ ; Spectra, far ultraviolet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A LCHO SCF-CI semiempirical scheme is formulated for compounds of carbon and hydrogen, and far-UV transition energies computed for a number of acyclic alkanes. The type of spectral bands (CH → CH*, etc.) and symmetries of subbands are assigned, and their dependence on conformation and branching discussed. It is argued that, for pentanes and higher alkanes, spectral quantities can be estimated from data on the lower alkanes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00548685
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Comments on the electronic properties of cyclopropane, cyclobutane, and cyclohexane (1977)
    Springer
    Theoretical chemistry accounts 45 (1977), S. 45-52 
    Details
    ISSN: 1432-2234
    Keywords: Hybrids, linear combination of ∼ ; Saturated organic compounds, MO treatment of ∼ ; Spectra, far ultraviolet ∼ ; Cyclobutane, auxochromic effect of ∼
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Spectral quantities of cyclopropane, cyclobutane, cyclohexane, and of several derivatives, have been calculated by a semiempirical all-valence electron SCF-CI MO method. In cyclopropane, HOMO is practically localized in the carbon-frame, and LVMO is purely so. In cyclobutane, these two MO's are based on C-H bonds, while cyclohexane holds an intermediate position. Despite the overall similarity-experimental and computed-of the spectra of these molecules, assignments are non-parallel. Like cyclopropane, cyclobutane can extend conjugation, but to a diminished degree; cyclohexane behaves in this respect like an acyclic alkane. An interpretation of this gradation, in terms of the nature of high-lying MO's, is proposed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00551457
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Molecular-orbital realizations of the bent-bond model: Spiranic derivatives of cyclobutanone (1978)
    Springer
    Theoretical chemistry accounts 47 (1978), S. 27-38 
    Details
    ISSN: 1432-2234
    Keywords: Hybrids, linear combination of ∼ ; Saturated organic compounds, MO treatment of ∼ ; Small rings ; Carbonyl stretching frequency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In the frame of our studies on small-ring compounds, we deal here with structures in which a three-membered ring and a carbonylated four-membered ring are fixed in close proximity. The theoretical approach is through an allvalence electron semiempirical method. The experimental background, based on results of other workers, comprises mainly UV and IR spectral data. The main topics to be discussed are: charge-donation and charge-transfer from the 3-ring, hypsochromic and bathochromic shifts of electronic transitions related to the carbonyl, direct substituent effects on the carbonyl stretching frequency, and the across-ring interaction in cyclobutanone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00554694
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    α-Adrenoceptor-mediated inhibitory effect of the sympathetic nervous system on the isoprenaline-induced increase in plasma renin concentration (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 299 (1977), S. 77-82 
    Details
    ISSN: 1432-1912
    Keywords: α-Adrenoceptors ; Isoprenaline ; Renin ; Sympathetic nervous system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The importance of the sympatho-adrenal system for the isoprenaline-induced increase in plasma renin concentration was investigated in conscious rats. Ganglionic blockade by trimethidinium (10 mg kg−1) increased the dose-dependent elevation of plasma renin concentration induced by isoprenaline (0.03–0.48 μg kg−1 min−1). Also treatment of the rats with guanethidine (6 mg kg−1) or reserpine (2.5 mg kg−1, given 16 and 7 h prior to the experiments) further increased the effect of isoprenaline (0.5 μg kg−1 min−1) on plasma renin concentration. Unilateral renal denervation combined with contralateral nephrectomy doubled the effect of the β-sympathomimetic amine on renin release. The α-adrenoceptor antagonist phenoxybenzamine (3 mg kg−1) also enhanced the effect of isoprenaline on this parameter. It is concluded that apart from a stimulation of renin release via β-adrenoceptors the sympathetic nervous system may inhibit renin release via stimulation of α-adrenoceptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00508641
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Suppression of isoprenaline-induced increase in plasma renin concentration by vasoconstrictors in rats with nonfunctioning Macula densa (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 290 (1975), S. 315-321 
    Details
    ISSN: 1432-1912
    Keywords: Isoprenaline ; Renin ; Vasoconstrictors ; Macula densa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The mechanism of the increase in plasma renin concentration caused by the β-sympathomimetic agent isoprenaline has been further investigated. Rats were pretreated by occluding the left renal artery for 2 hrs, thus rendering the macula densa cells of this kidney nonfunctioning. After contralateral nephrectomy infusion of isoprenaline (1.5 μg/kg min) still caused a strong increase in plasma renin concentration. This increase was significantly suppressed by simultaneous infusion of angiotensin II (1.0 μg/kg min), the α-sympathomimetic amine phenylephrine (60 μg/kg min) or octapressin (10 mU/kg min). The results exclude any mediator-role of the macula densa receptors in the isoprenaline-induced release of renin. The possibility of a stimulation of renin release via the baroreceptors or a direct “secretomotoric” action of isoprenaline is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510560
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    Paper (German National Licenses)
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