ISSN:
1432-0428
Keywords:
Diabetes
;
hypertrophy
;
kidney
;
nephrectomy
;
rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The kidney growth seen after the induction of experimental diabetes in rats has been compared to the compensatory renal growth after one-sided nephrectomy. After five days the kidney weight had increased from 650 ± 15 mg in a group of controls to 778 ± 21 mg in diabetic rats, and 764 ±17 mg in unilaterally nephrectomised rats. The increased weight was in both groups reflected in an increased DNA content and increased RNA/DNA and protein/DNA ratios. In a group of rats made diabetic and nephrectomised at the same time, kidney weight increased to 953 ± 22 mg after five days. When rats were unilaterally nephrectomised after 20 days of untreated diabetes, compensatory growth was much more pronounced than in non-diabetic rats, kidney weight rising from 780 ± 21 to 1144 ± 39 mg in five days. Similarly, in rats with established compensatory renal hypertrophy, diabetes induced a very rapid growth of the remaining kidney (1226 ± 46 mg after five days).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01223024
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