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  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of furosemide-induced renin release by vasoconstrictors (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 290 (1975), S. 307-314 
    Details
    ISSN: 1432-1912
    Keywords: Furosemide ; Renin Release ; Angiotensin II ; Octapressin ; Phenylephrine ; Vasoconstrictors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of i. v. infused (asp1-β-amid, val5)-angiotensin II (1.0 μg/kg min), octapressin (phe2, lys8-vasopressin) (10.0 mU/kg min) and of the α-sympathomimetic amine phenylephrine (40.0 μg/kg min) on the stimulation of renin secretion by furosemide (10.0 mg/kg i.v.) was investigated. The vasoconstrictors abolished the renin release induced by furosemide. Studies on the clearance of p-aminohippuric acid (PAH) (i.e. renal plasma flow) showed that the action of the vasoconstrictors cannot be explained by a decrease in access of furosemide to its intrarenal sites of action. The mechanism of the suppressive action of the vasoconstrictors on renin release is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510559
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Conversion of angiotensin I in isolated perfused guinea-pig and rat lung (1976)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 292 (1976), S. 183-187 
    Details
    ISSN: 1432-1912
    Keywords: Angiotensin I conversion ; SQ 20881 ; Angiotensin II ; Guinea-pig lung ; Rat lung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Increasing concentrations of angiotensin I and different perfusion rates were used to study the conversion of angiotensin I in guinea-pig and rat lungs. Even the highest concentration used (32.0 μM), which is a thousand times higher than that which occurs in vivo, was unable to saturate the converting system indicating the enormous capacity of this system. SQ 20881 proved to be a reversible inhibitor of the converting system. Its effect on the angiotensin I conversion was greater in guinea-pig lungs than in rat lungs (ID50 was 40.0 nM in guinea-pig lung and above 360.0 nM in rat lungs at a substrate concentration of 38.6 nM).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498590
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Inhibition of the adrenalectomy-induced increase in plasma renin concentration by vasoconstrictor agents in rats (1976)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 294 (1976), S. 187-192 
    Details
    ISSN: 1432-1912
    Keywords: Adrenalectomy ; Renin ; Angiotensin II ; Felypressin ; Phenylephrine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Plasma renin concentrations in rats increase after bilateral adrenalectomy without sodium substitution. The effects of i.v. infused (asp1-β-amid, val5)-angiotensin II (1 μg/kg min), felypressin (phen2, lys8-vasopressin) (40 mU/kg min) and phenylephrine (30 μg/kg min) were investigated on the increase in plasma renin concentration. These effects of the agents were compared with their actions on blood pressure, heart rate and renal hemodynamics. In rats with destroyed macula densa cells the effect of bilateral adrenalectomy without sodium substitution was also studied. Adrenalectomy still increased the plasma renin concentration. Angiotensin II and felypressin, also depressed under these conditions the elevation of plasma renin concentration caused by adrenalectomy. The mechanism of the adrenalectomy-induced reinin release and its suppression by vasoconstrictor agents is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00507852
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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