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  • 1975-1979  (2)
  • Atrophisierung der Epidermis  (1)
  • Sequential renal scanning  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Changes in blood flow and vasculature of the dog kidney undergoing normothermic and hypothermic ischaemia (1977)
    Springer
    Urological research 5 (1977), S. 7-13 
    Details
    ISSN: 1434-0879
    Keywords: Hypothermia ; Ischaemia ; Renal blood flow ; Xenon wash out technique ; Sequential renal scanning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 11 mongrel dogs both kidneys have been subjected to a 2 h ischaemic period. One kidney was cooled by perfusing the renal artery at 4°C while the contralateral normothermic kidney was clamped for 2 h. Studying the renal blood flow using the Xenon wash out technique, sequential renal scanning and angiography, marked differences between hypo- and normothermic ischaemia kidneys were observed. One or two hours following hypothermic perfusion a marked decrease of blood flow in the first compartment and vasoconstriction was evident, while within this period following normothermic ischaemia an enhanced renal blood flow was observed. After 24 h renal blood flow and renal function tested by 131I-Hippuran clearance returned to normal values. Angiographic studies corresponded to the preoperative findings. In contrast, normothermic ischaemia kidneys showed a decreased renal blood flow, impairment of kidney function in isotope studies and pathological angiographic changes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257110
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effect of systemic treatment with 5-fluorouracil on the epidermis of the guinea pig (1978)
    Springer
    Archives of dermatological research 263 (1978), S. 31-35 
    Details
    ISSN: 1432-069X
    Keywords: 5-Fluorouracil ; 3H thymidine labelling index ; Mitoses in the epidermis ; Atrophy of the epidermis ; S-phase ; 5-Fluorouracil ; 3H-Thymidin-Labelling-Index ; Mitosen in der Epidermis ; Atrophisierung der Epidermis ; DNS-Synthesezeit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Vor und während einer Behandlung mit 5-Fluorouracil (1 mg i.p. in 2tägigem Abstand/100 g KG) wurde beim Meerschweinchen der 3H-Thymidin-Labelling-Index in der Basalschicht der Epidermis bestimmt. Parallel wurde die Zahl der in der Metaphase blockierbaren Mitosen in der Epidermis mit der Colcemidmethode ermittelt. Außerdem wurden Epidermisfläche, Epidermisdicke, Zellzahl in der Epidermis und Zellgröße in der Epidermis analysiert. 5-Fluorouracil reduziert den 3H-Thymidin-Labelling-Index und die Mitoserate bei der Colcemidmethode in der gleichen Weise, wobei der Effekt erst nach einer Behandlungszeit von mehr als 22 Tagen voll zum Tragen kommt. Die Parallelität dieser Befunde läßt annehmen, daß die DNS-Synthesezeit nicht wesentlich verändert wird, wenn man sie vom Zeitpunkt der Thymidin-Synthese an rechnet. Zeitlich parallel kommt es außerdem zu einer Atrophisierung der Epidermis.
    Notes: Summary The thymidine labelling index and the mitosis rate (blocked by colcemid) in the basal cell layer of the guinea pig were determined before and during treatment with 5-fluorouracil (1 mg i.p. in 2 day's interval/100 g body weight). Additionally, the epidermal area and thickness and the number and size of cells were measured. 5-Fluorouracil equally reduces the thymidine labelling index and the mitosis rate with the full effect after treatment of at least 22 days. From these findings it is concluded that the S-phase — calculated from the end of the thymidine synthesis — is not altered. Furthermore atrophy of the epidermis runs parallel with the reduction of the 3H thymidine labelling index and the mitosis rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446851
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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