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  • 1975-1979  (2)
  • Clearance  (1)
  • Microperfusion  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Handling of allantoin by the rat kidney (1975)
    Springer
    Pflügers Archiv 357 (1975), S. 201-207 
    Details
    ISSN: 1432-2013
    Keywords: Allantoin ; Uricase ; Kidney ; Clearance ; Micropuncture ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Renal excretion of allantoin was measured by tracer techniques. After injection of 2-C14 urate and H3 inulin, clearances of allantoin and inulin were measured and both proximal and distal tubules were micropunctured. In confirmation of earlier results 2-C14 urate injected into an intact animal is very rapidly converted to C14 allantoin: after 15 min more than 90% of urinary tracer is present as allantoin. It was further observed that 1) allantoin clearance is essentially identical with inulin clearance over a wide range of urine flows; 2) no net transport of allantoin occurs in either proximal or distal tubules. Clearly allantoin is handled by the rat kidney like inulin. The total excretion of filtered allantoin unlike that of filtered urate provides an easy and effective mechanism for animals possessing the enzyme uricase to dispose of their purine loads.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585975
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Handling of oxalate by the rat kidney (1978)
    Springer
    Pflügers Archiv 374 (1978), S. 243-248 
    Details
    ISSN: 1432-2013
    Keywords: Oxalate ; Wistar rat ; Microperfusion ; Microinfusion ; Organic acid secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Renal transport of14C-oxalate was studied in the rat by clearance and micropuncture techniques. The ultrafilterability of oxalate was 0.98±0.02 (n=7). Fractional clearance of oxalate was significantly above unity in antidiuresis and volume expansion: mean 1.24 ±0.04 (n=115). Pyrazinamide (1.1·10−3 mol/kg BW) and probenecid (0.35·10−3 mol/kg BW) had no significant effect on oxalate clearance. P-aminohippurate (1.45·10−3 mol/kg BW) and urate (0.48 ·10−3 mol/kg BW) depressed the fractional clearance of oxalate significantly from 116 to 91 and from 125 to 90%, respectively. Excess excretion of14C-oxalate over3H-inulin was invariably demonstrable in peritubular microperfusion experiments (n=5) and in microinfusions underneath the kidney capsule (n=4). Together with the first 50% of3H-inulin 58±2% of the total14C-oxalate were excreted in the peritubular microperfusions, and 64±3% in the subcapsular microinfusions. In tubular microinfusion experiments (n=36) urinary14C-oxalate recovery was almost complete after early proximal microinfusion (93±4%) and complete after late proximal microinfusion (102±4%). In continuous microperfusion experiments of proximal tubules (n=42) a small but highly significant outflux of14C-oxalate of 7% per mm perfusion distance was found. The data suggest that oxalate is freely filterable at the glomerular site. A small but significant amount of oxalate is reabsorbed in the proximal nephron. Most likely at the same site and in the pars recta oxalate is secreted and tubular load increased to 124% of filtered load. This amount is excreted in final urine. The secretion of oxalate is inhibited by organic acids which are known to be secreted by the proximal tubule and the pars recta.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00585601
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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