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  • 1975-1979  (2)
  • Corticotropin releasing factor  (1)
  • X chromosome  (1)
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  • 1975-1979  (2)
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Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Influence of adrenalectomy, total body X-irradiation and dexamethasone on the amount of CRF-Granules and “classical” neurosecretory material in the rat neurohypophysis (1975)
    Springer
    Anatomy and embryology 148 (1975), S. 267-278 
    Details
    ISSN: 1432-0568
    Keywords: Corticotropin releasing factor ; Neurosecretion ; Hypophysis ; X-irradiation ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In 195 female Wistar rats the influence of adrenalectomy, total body X-irradiation and dexamethasone treatment on the amount of CRF-granules in the external zone of the median eminence and “classical” neurosecretory material (NSM) in the internal zone of the median and in the posterior lobe of the hypophysis has been studied. In the normal rat only very few CRF-granules occur. 15 days after adrenalectomy increased amounts of CRF-granules but normal amounts of “classical” NSM are found. X-irradiation leads to a slight diminishment of “classical” NSM in normal rats. In adrenalectomized animals X-irradiation causes no changes in the amount of “classical” NSM but a marked decrease in the amount of CRF-granules. Application of dexamethasone from the 15th to 18th day after adrenalectomy enhances the augmentation of CRF-granules in irradiated and non-irradiated rats but does not influence the amount of “classical” NSM. The findings show that no correlation exists between the quantitative changes of CRF-granules and “classical” NSM under the experimental conditions used. Therefore it is to be assumed that the release of the two substances is regulated by different control mechanisms and that the substances have a different functional significance. The observations do not exclude the possibility that CRF-granules and “classical” NSM are biochemically identical.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319847
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A lod score method for detecting linkage on the X chromosome between a marker locus and a major gene locus for a quantitative character (1979)
    Springer
    Behavior genetics 9 (1979), S. 139-149 
    Details
    ISSN: 1573-3297
    Keywords: linkage ; X chromosome ; lod score ; quantitative character ; major gene ; marker locus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Psychology
    Notes: Abstract A sequential lod-score method is proposed for detecting linkage on the X chromosome between a marker locus and the locus of a major gene influencing a quantitative trait. The method uses information from sons of doubly heterozygous mothers. The average number of families required to detect linkage is substantially less than that of the fixed sample-size method proposed by Hill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01071297
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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