Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Scandinavian journal of immunology
11 (1980), S. 0
ISSN:
1365-3083
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Administration of d-penicillamine (50 mg/kg/day orally) for 4 days increased the uptake of 3H-thymidine (3H-TdR) in unstimulated and concanavalin -A-stimulated unseparated lymph node and spleen cells from Lewis rats. Increased 3H-TdR incorporation was also found in cultures depleted of adherent cells. d-Penicillamine treatment did not increase the incorporation of 3H-TdR in lymph node and spleen cells from rats concomitantly treated with the selective macro-phage toxin silica. in contrast, treatment with d-penicillamine during the last 4 days of silica treatment sometimes resulted in a marked decrease in 3H-TdR incorporation. It is suggested that d-penicillamine treatment in vivo is able to enhance the responsiveness of the lymphocytes, dependent on the presence of functionally intact macrophages. The increased response vanished after 2-3 weeks, even with continuous administration of d-penicillamine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-3083.1980.tb00204.x
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