Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    An effective dynamic interaction for the two-particle propagator (1975)
    Springer
    The European physical journal 273 (1975), S. 269-276 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract In nuclear structure calculations the collective excitations of the core introduce dynamic effects in the interaction between particles. Under the restriction of including forward-going contributions only, it is shown that the two-particle propagator which yields the spectra and two-particle transfer strengths of nuclei with two nucleons outside a closed shell, can be written in a Dyson-like equation in which a two-particle self-energy or dynamic effective interactionΔ is introduced. An expression forΔ is given in terms of the irreducible vertex part of the Bethe-Salpeter equation and partial summations forΔ using phonon exchange interactions to represent the core-polarization diagrams, are discussed. The single-particle propagators are also dressed with phonon-exchange contributions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01410009
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Antipsychotic drugs and dopamine-mediated responses in Aplysia neurons (1976)
    Springer
    Journal of neural transmission 39 (1976), S. 187-208 
    Details
    ISSN: 1435-1463
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of antipsychotic drugs was tested on responses to micro-electrophoretically applied dopamine, acetylcholine and 5-hydroxy-tryptamine in identified neurons of the marine gastropod Aplysia californica. Fluphenazine was able to depress the response to DA in concentration of 10μM, with 100μM DA-responses of many neurons were blocked completely. Thioridazine (10 and 100μM) and haloperidol (50μM) were also effective in depressing DA-responses, while the non-antipsychotic phenothiazines mepazine (10 and 100μM) and promethazine (100μM) had only a slight action on DA-receptors. ACh-and 5-HT-responses were slightly affected only by high concentrations after long lasting perfusion. The investigated drugs had no persistent or only an insignificant effect on resting membrane potential and amplitude of action potentials of the neurons. With haloperidol depolarizing afterpotentials leading to double discharges were observed in some neurons. In a few instances spontaneous EPSPs disappeared with the DA-response under the influence of anti-psychotic drugs. The results render a direct neurophysiological evidence for the blockade of DA-receptors by antipsychotic drugs in correspondence to their clinical efficacy and agree with data from clinical observations and obtained in neurochemical, behavioral and indirect neurophysiological experiments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01256509
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Morphological changes in anaplastic gliomas treated with radiation and chemotherapy (1977)
    Springer
    Acta neurochirurgica 36 (1977), S. 117-138 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Wirkung anuneoplastisdier Behandlung auf Gliome ist abhängig von der Tumorzeil- und Proliferationskinetik, der Gliomarchitektur und dem umgebenden Hirngewebe. Durch Strahlen- und Chemotherapie induzierte morphologische Veränderungen sind gekennzeichnet durch Zellnekrosen sowie schwere Zell- und Kernschäden durch Eingriffe in die Zellkinetik, doch können diese auch spontan in unbehandelten anaplastischen Gliomen auftreten. Vergleichsuntersuchungen von zytologischen Abstrichen und histologischen Routinepräparaten an Biopsie- und Autopsiematerial von 4 Gruppen anaplastischer Astrozytome und Glioblastome (78 Fälle) wurden nach postoperativer Strahlenbehandlung, Polychemotherapie und CCNU-Behandlung sowie ohne spezifische postoperative Therapie (Kontrollgruppe) vorgenommen. Nach Strahlen- und Chemotherapie fanden sich neben gesteigerter Nekrose und Gefäßreaktion verschiedene charakteristische, aber unspezifische Zell- und Kernveränderungen mit gesteigerter Neigung zur Bildung vielkerniger Riesen- und Monsterzellen, Kernhyperchromasie sowie schwerer Zytoplasmadegeneration als Hinweise auf Mitosestörungen und Zellschädigung. Nach antineoplastischer Therapie fand sich eine statistisch signifikante Zunahme von Riesen- und vielkernigen Monsterzellen sowie Abnahme der Mitosen, wobei diese Veränderungen nach Chemotherapie stärker ausgeprägt waren als nach Bestrahlung. Zwischen Polychemo- und CCNU-Behandlung ergaben sich keine wesentlichen Abweichungen. Die Bedeutung dieser zytologischen Spätbefunde auf die Effekte antineoplastischer Behandlung anaplastischer Gliome wird diskutiert.
    Notes: Summary The effects of antineoplastic treatment on gliomas are related to tumour cell cycle and proliferation kinetics, glioma tissue architecture, and the surrounding environment. Morphological changes induced by radiation and chemotherapy are characterized by cell necrosis and severe alterations in cell and nuclear morphology caused by changes in the cell kinetic parameters which, however, may also occur spontaneously in untreated anaplastic gliomas. Comparative studies of cytological imprints and routine histological preparations of biopsy and autopsy specimens were performed in four groups of anaplastic astrocytomas and glioblastomas (78 cases) with postsurgical irradiation, combination chemotherapy, and CCNU treatment, and without specific postsurgical treatment (control group). Following radiation and chemotherapy, in addition to increased necrosis and vascular response, a variety of characteristic but nonspecific changes were observed in cell and nuclear morphology with prominent formation of multinucleated giant and monstrous cells, irregular and hyperchromatic nuclei, and severe cytoplasmic degeneration indicating both inhibition of cell division and cell damage. Statistically significant findings were a posttreatment increase in the number of multinucleated giant and monstrous cells and a decrease in the number of mitoses. These changes were more pronounced after chemotherapy than after radiation, while no significant dissimilarities were found between combination chemotherapy and CCNU. The implications of these changes on the mechanisms of antitumour treatment in anaplastic gliomas are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405993
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Chemotherapy of malignant gliomas: Comparison of the effect of polychemo- and CCNU-therapy (1978)
    Springer
    Acta neurochirurgica 42 (1978), S. 109-115 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Postoperative survival times of patients suffering from glioblastoma (astrozytoma III-IV) were compared in unselected groups receiving different forms of therapy: standard surgical therapy (16 cases, mean survival time 6.27±3.75 months), postoperative polychemotherapy (16 patients, survival time 8.96±4.97 months) or postoperative CCNU-monotherapy (24 cases, survival time 6.98±4.46 months). The mean survival time in the group receiving polychemotherapy was prolonged significantly when compared to the group with standard treatment. Survival time of the patient group treated with CCNU was not significantly increased. The results indicate that postoperative combination chemotherapy is more effective than CCNU monotherapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01406637
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Scintigraphy in lymphomas and leukemia of the brain (1976)
    Springer
    Neuroradiology 10 (1976), S. 251-255 
    Details
    ISSN: 1432-1920
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Dans quatre cas de lymphome malin et dans un cas de leucémie myéloblastique, les auteurs ont observé des foyers cérébraux. Les localisations sont vérifiées tant par biopsie que par autopsie.
    Abstract: Zusammenfassung Gehirnszintigraphie mit 99mTc-Pertechnetat ergab bei 4 Patienten mit primären malignen Lymphomen des Gehirns, einem Patienten mit zerebraler Mitbeteiligung des Gehirns bei primärem Lymphknoten-Immunoblastom, einem Patienten mit Sézary-Syndrom (Mycosis fungoides und T-Zellen Leukämie) und einem Kind mit raumforderndem Infiltrat bei myeloblastischer Leukämie herdförmige pathologische Speicherungen. Diese Befunde wurden bioptisch oder autoptisch verifiziert und makroskopisch und histologisch belegt.
    Notes: Summary Scintigraphy with 99mTc-pertechnetate made it possible to detect focal brain lesions in 4 patients with primary malignant lymphomas of the brain, one patient with CNS involvement with lymphatic immunoblastoma, one patient with Sézary syndrome (mycosis fungoides and T cell leukemia) and one child with a space occupying infiltration of myeloblastic leukemia. The scintigraphic results were verified by morphological data from biopsy or autopsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327573
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    A technique for recording local blood flow and neuronal activity with a single microelectrode (1977)
    Springer
    Pflügers Archiv 369 (1977), S. 183-186 
    Details
    ISSN: 1432-2013
    Keywords: local blood flow ; hydrogen clearance method ; unit activity ; cortex ; micro-electrodes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A technique is presented for recording both local blood flow, by means of hydrogen clearance method, and neuronal activity of the cat's cortex using a single microelectrode. The requirements of electrodes for recording cerebral blood flow are different from those for recording extracellular spikes. Only electrodes within a small range of impedance (measured at 10 Hz) are suitable to record both. A bridge method is used for the recordings. The bridge signal is split in order to amplify cell activities and H2 responses separately. Three examples demonstrate the method and the importance of appropriately selected electrodes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00591575
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Electrophysiological studies on the “Stiff-man” Syndrome (1977)
    Springer
    Journal of neurology 217 (1977), S. 111-121 
    Details
    ISSN: 1432-1459
    Keywords: Stiff-man syndrome ; Electrophysiology ; Pharmacology ; Pathophysiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird über 2 Patienten mit einem stiff-man Syndrom berichtet. Neben Anamnese und klinischem Bild sind elektrophysiologische und pharmakodynamische Untersuchungen zur Diagnose erforderlich. Elektromyographisch findet sich eine Daueraktivität motorischer Einheiten, welche zeitweise, entsprechend Muskelspasmen, von bursts von Aktionspotentialgruppen überlagert wird, bei sonst normalen Elektromyogramm. Die Steifigkeit sowie die Daueraktivität motorischer Einheiten verschwindet im Schlaf, nach intravenöser Gabe von Tubocurarin und Diazepam, in Penthotalnarkose und nach lokaler Nervenblockade mit Procain. Biperidenlactat und Magnesiumlaevulinat intravenös zeigten eine nur flüchtige Wirkung. Die orale Gabe von Dipropylessigsäure und Baclofen führten zu einer Besserung, jedoch zu keiner kompletten Muskelerschlaffung. Dagegen hatten Prostigmin, Hydantoine, Glycin, Dopa und Tryptophan eine nur geringe oder keine Wirkung. Bei passiver Dehnung und Verkürzung des M. biceps brachii und bei Bestreichen der Haut mit einem Wattestäbchen erfolgte eine Aktivitätszunahme und Ausbreitung auf andere Segmente und die kontralaterale Seite. Die H/M ratio war gegenüber der Norm erhöht, die Silent period normal. Als therapeutisch wirksam erwies sich Diazepam kombiniert mit Clonazepam bzw. mit Dipropylessigsäure. Mögliche pathophysiologische Mechanismen werden diskutiert und eine zentrale Genese angenommen.
    Notes: Summary In addition to anamnestic and clinical data electrophysiological and pharmacokinetic investigations may be necessary for the diagnosis of stiff man syndrome. Continuous activity of motor units with superimposed bursts during muscular spasms was found by electromyography in the two patients reported. Rigidity and continuous activity disappears during sleep, after i. v. application of Tubocurarine and Diazepam, during Thiopental anesthesia and after neural block with Procaine. Dipropylacetate and Baclofen improved the condition but did not lead to complete relaxation. Biperidenlactat and Magnesiumlaevulinat have only a temporary effect on rigidity. Neostigmine, Phenytoine, Glycine, Dopa and 5-Hydroxy-Tryptophan had no effect. Passive shortening or stretching of the m. biceps brachii as well as touching the skin increased motor activity which spread to other segments and to the contralateral side. The H/M ratio was increased but the silent period was normal. A combination of Diazepam and Dipropylacetate or Clonazepam was therapeutically effective in the cases reported. A central genesis, of the pathogenetic mechanisms discussed, is the most probable in our cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312924
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Spastic paraplegia associated with addison's disease: Adult variant of adreno-leukodystrophy (1976)
    Springer
    Journal of neurology 213 (1976), S. 237-250 
    Details
    ISSN: 1432-1459
    Keywords: Adreno-leukodystrophy ; Adrenal gland diseases ; Paraplegia ; Spinal cord diseases ; Metabolic diseases ; Leukodystrophy ; Demyelination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Klinische und pathologische Befunde einer adulten Form der Adrenoleukodystrophie (ALD) werden dargestellt. Ein Patient mit klinischem Bild und Laboratoriumsbefunden der Addison-Krankheit (AD) entwickelte im Alter von 22 Jahren eine sehr langsam zunehmende Paraspastik mit geringer Hypaesthesie in beiden Beinen und Blasenund Mastdarmstörungen; er verstarb im Alter von 24 Jahren in einer AD-Krise. Bei der Autopsie fanden sich eine Hyperplasie des lymphatischen Apparats und lymphocytäre Infiltrate in verschiedenen Organen einschließlich des ZNS; beide Nebennieren waren atroph mit Hervortreten großer ballonierter, etwas bizarrer Rindenzellen mit gelegentlicher cytoplasmatischer Streifung. Im ZNS fanden sich pseudosystematische inkomplette Entmarkungen der langen Bahnen in Hirnstamm und Rückenmark mit Betonung der Pyramidenbahn, charakterisiert durch perivasale Manschetten „epitheloider“ histiocytärer Zellen, die ein stark PAS-positives sudannegatives Material enthielten. Elektronenoptisch wurde eine massive Speicherung eines lamellären Materials in perivasalen Histiocyten nachgewiesen, welches mit den als spezifisch für die ALD angesehenen Einschlüssen übereinstimmte. Einige derartige Strukturen zeigten einen engen Zusammenhang mit kompakten Lamellenaggregaten und mit einem elektronendichten „fingerprint“-Material innerhalb von Astrocyten. In diesem Fall konnte das Paraplegie-AD-Syndrom, welches mehrfach bereits klinisch beschrieben worden war, aufgrund neuropathologischer Befunde als adulte Variante der ALD klassifiziert werden. Die Unterschiede dieser Form zur „klassischen“ ALD, welche üblicherweise Knaben betrifft, werden hervorgehoben: das Überwiegen der endokrinen Symptomatik, was das Auftreten perivasaler Lymphocytensäume im ZNS zum Teil bedingen dürfte; das Fehlen klinischer und pathologischer Hinweise auf diffuse Beteiligung des Großhirns und die spezielle Topik der ZNS-Läsionen und die geringe Progredienz der neurologischen Symptomatik, welche im Einklang mit dem Fehlen florider sudanophiler Entmarkungsvorgänge steht. Der Mechanismus der Entmarkung und die Art der vermuteten metabolischen Störung bei der ALD werden diskutiert. Die elektronenoptisch charakteristischen lamellären Strukturen könnten aus dem Myelinabbau stammen, und damit könnte bei der ALD eine pathologische Speicherung eines Myelinabbauprodukts vorliegen.
    Notes: Summary Clinical and pathological features of an adult variant of adreno-leukodystrophy (ALD) are presented. A male with clinical and laboratory signs of Addison's disease (AD) developed at age 22 a slowly progressing paraplegia with slight sensory deficits in both legs and bladder and sphincter dysfunctions; he died at age 24 in an AD crisis. Autopsy revealed hyperplasia of lymphatic tissues, lymphocytic infiltrates in various organs including the CNS and adrenocortical atrophy with prominence of large ballooned, sometimes bizarre and occasionally striated cortical cells. CNS lesions consisted in incomplete demyelination of long tracts of brain stem and spinal cord with accentuation in the pyramical tracts; in these areas, perivascular cuffs of “epitheloid” histiocytic cells contained a strongly PAS-positive non-sudanophilic material. Electron microscopy demonstrated massive storage of leaflet structures in perivascular histiocytes identical to the lamellar profiles previously described as specific for ALD. Some leaflets were found in close contact with compact lamellar arrays and with an electron-dense fingerprint material within astrocytes. In our case, the spastic paraplegia-AD syndrome which has been described previously in several clinical observations could be neuropathologically classified as an adult variant of ALD. Several differences to “classical” ALD occurring in young boys are stressed: the predominance of the endocrine disorder probably accounting for some of the perivascular lymphocytic infiltrates within the CNS; the absence of both clinical and pathological signs of diffuse cerebral involvement and the peculiar topistic pattern of CNS lesions and the very slow evolution of neurological signs paralleled by the absence of active sudanophilic demyelinating lesions. The possible mechanism of demyelination and the nature of the suggested metabolic defect in ALD are discussed. The ultrastructurally prominent leaflet structures may originate from myelin remnants, thus relating ALD to pathological storage of a myelin degradation product.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312873
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...