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  • 1
    Electronic Resource
    Electronic Resource
    INFLUENCE OF THE THYMUS-CORTICOTROPIN-GROWTH HORMONE INTERACTION ON THE REJECTION OF SKIN ALLOGRAFTS IN THE RAT (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 249 (1975), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1975.tb29087.x
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  • 2
    Electronic Resource
    Electronic Resource
    Die Erythrozytenalterung als Modell für die pharmakologische Beeinflussung der Erythrozytenverformbarkeit (1979)
    Springer
    Rheologica acta 18 (1979), S. 134-138 
    Details
    ISSN: 1435-1528
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Summary The methods to measure red cell flexibility are reviewed and own investigations reported based on red cell aging as a model for a physiological reduction in red cell flexibility. The measurement of this parameter was performed with whole-blood by means of filtration through filters with a pore diameter of 5 µm. The model of red cell aging and the method used for the measurement of red cell flexibility is suitable as a screening system to evaluate whether chemical compounds influence red cell flexibility. In two series of experiments pentoxifylline in concentrations of 10 µg and 20 µg/ml of blood and theophylline and prednisolone in concentrations of 96.6 µg or 20 µg/ml of blood, respectively, were investigated. For pentoxifylline a dose-dependent increase in red cell flexibility was observed, theophylline and prednisolone did not change this parameter in comparison to the control. The effect of pentoxifylline is probably related to an increase in red cell ATP content. Scanning electron microscopy revealed that this compound does not influence the outer membrane of the red cells.
    Notes: Zusammenfassung Es werden die Möglichkeiten der Messung der Erythrozytenverformbarkeit dargestellt und eigene Untersuchungen mit einer Methode beschrieben, welche die Erythrozytenalterung als Modell für eine physiologische Reduzierung der Erythrozytenverformbarkeit benutzt. Die Messung dieser Größe erfolgt in Vollblut mittels Filtration durch Filter mit Poren von 5 µm. Das Erythrozytenalterungsmodell und die Methode zur Messung der Erythrozytenverformbarkeit eignet sich für die routinemäßige Prüfung, ob chemische Substanzen die Erythrozytenverformbarkeit beeinflussen. In zwei Untersuchungsserien wurden Pentoxifyllin in Konzentrationen von 10 µg und 20 µg/ml Blut sowie Theophyllin in einer Konzentration von 96,6 µg/ml Blut und Prednisolon in einer Konzentration von 20 µg/ml Blut untersucht. Für Pentoxifyllin fand sich eine dosisabhängige Erhöhung der Erythrozytenverformbarkeit, unter Theophyllin und Prednisolon fanden sich keine signifikanten Änderungen gegenüber der Kontrolle. Der Effekt von Pentoxifyllin ist wahrscheinlich in einer Erhöhung des erythrozytären ATP-Gehaltes begründet. Rasterelektronenmikroskopische Untersuchungen zeigen, daß die morphologische Struktur der äußeren Erythrozytenmembran durch Pentoxifyllin nicht beeinflußt wird.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01515697
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  • 3
    Electronic Resource
    Electronic Resource
    Untersuchungen über den Einfluss von Thrombozyten und Temperatur auf die Vollblut- und Plasmaviskosität als Vergleichsmessung zwischen einem Kapillar- und Platte-Kegel-Viskosimeter (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 1179-1181 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The capillary viscosimeter (Viscotimer) tested with different Ubbelohde-viscosimeters is suitable for measurements of plasmaviscosity; the limitting factor of the measuring method is the exact adjustment of the temperature. When testing the plate-cone-viscosimeter (Wells-Brookfield Microviscosimeter), we achieved scientifically adequate results only when using shear rates 230, 115 and 46 sec−1. An influence of different thrombocyte-concentrations on the viscosity of whole blood and plasma could not be detected. The flow capacity of whole blood and plasma is distinctly dependent on the temperature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02326781
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  • 4
    Electronic Resource
    Electronic Resource
    Methodische Untersuchungen zur Messung der Erythrozytenverformbarkeit (Filtrabilität, Flexibilität, Fluidität) in Abhängigkeit der Plasmaviskosität, der Plasma-Proteine, des Hämatokrits, des Filtrationsdruckes sowie der Osmolarität (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 179-181 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The measurement of red cell deformability (flexibility or fluidity) according to the method of filtration strongly depends on the suspension medium, the hematokrit, filtration pressure as well as osmolarity and is hard to differentiate over the influence of red cell aggregation. Therefore, data concerning the flexibility of red cells have to be established under standardized conditions, e.g. suspension medium, such as albumin, stabilized hematokrit, constant osmolarity and pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02124052
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  • 5
    Electronic Resource
    Electronic Resource
    Influence of the adrenal cortex on allograft rejections in rats (1979)
    Springer
    Research in experimental medicine 175 (1979), S. 51-59 
    Details
    ISSN: 1433-8580
    Keywords: Corticosteroids (influence on allograft rejection) ; Adrenal thymus (allograft rejection)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary I. The bibliography about corticosteroid influence on immune response is briefly reviewed. Generally, it is admitted that corticosteroids are immunosuppressive when administered in large amounts. Divergent opinions are recalled. II. The aims of the experiments are summarized: A) Investigate on the influence of corticoids (given in just substitutive amounts) on skin allograft rejection. B) Investigate on possible interactions between adrenal cortex and thymus with this test. III. It was observed, that A) Adrenalectomy resulted in a significant delay of allograft rejection. B) This could be suppressed partially by administering aldosterone, corticosterone, and desoxycorticosterone and completely by administering at least two of these hormones. C) Cortisol had shown a minor inhibitory influence. D) There was no obvious difference between adrenalectomized and thymectomized rats and those adrenalectomized only. IV. These observations are replaced in the context of bibliography and their significance is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851233
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  • 6
    Electronic Resource
    Electronic Resource
    Recent observations on ependyma and subependymal basement membranes (1975)
    Springer
    Acta neurochirurgica 31 (1975), S. 153-159 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Directly under the ependyma, and between the ependymal cells, there are basement membranes which form labyrinths connecting with the perivascular basement membranes of the subependymal vessels. The basement membranes exhibit differences in form, position, and distribution, and they can be distended by fluid absorption into large lacunae. The membranes can be identified as glycoprotein and glylcolipid substances. Electron microscopic studies have shown the differences between the basement membrane labyrinths of the human, the rabbit and the rat. In the human, the labyrinths contain isolated collagen fibrils. Basement membranes generally line all connective tissue spaces and form their interstitial borders. From this point of view, the subependymal basement membrane labyrinths can be seen as interstitial spaces near the ventricles, forming pathways between the ependyma and the subependymal capillaries or postcapillary veins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01406287
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  • 7
    Electronic Resource
    Electronic Resource
    Paired vessels in the spinal cord of rhesus monkey and cat (1978)
    Springer
    Anatomy and embryology 152 (1978), S. 325-329 
    Details
    ISSN: 1432-0568
    Keywords: Spinal cord (rhesus monkey, cat) ; Paired vessels ; Blood supply of individual spinal segments
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the spinal cord of the rhesus monkey and of the cat paired vessels near the central canal are described. These paired vessels, consisting of one artery and one vein, are enveloped by a common glial sheath. In some Virchow-Robin's spaces two arteries and two veins can be observed. The physiological significance of this morphological feature is briefly discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00350528
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of pentoxifylline on red blood cell deformability and blood viscosity under hyperosmolar conditions (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 299 (1977), S. 197-200 
    Details
    ISSN: 1432-1912
    Keywords: Blood viscosity ; Red cell deformability ; Pentoxifylline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using a hyperosmolar erythrocyte model, the authors studied the effect of changes in red cell deformability on whole blood viscosity and investigated the possibility of using pentoxifylline to modify red cell deformability and whole blood viscosity. In vitro studies reveal a significant correlation between the two parameters in as much as they are inversely proportionate, i.e. viscosity increases as red cell deformability decreases and vice versa. Addition of pentoxifylline improves impaired red cell deformability under hyperosmolar conditions and simultaneously produces a reduction in whole blood viscosity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498562
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  • 9
    Electronic Resource
    Electronic Resource
    Influence of clofibrate on blood viscosity in primary hyperlipoproteinemia (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 43-47 
    Details
    ISSN: 1432-1440
    Keywords: Blutviskosität ; Hyperlipoproteinämie ; Clofibrattherapie ; Blood viscosity ; Hyperlipoproteinemia ; Clofibrate therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In patients with primary hyperlipoproteinemia (23 patients type II a and II b, 13 patients type IV), changes in lipoprotein concentrations (lipid fraction), fibrinogen concentrations, in kinematic serum and plasma viscosity (determined by means of a capillary viscosimeter) and changes in relative apparent viscosity at shear rate 46 s−1 and 115 s−1 (determined by means of a plate-cone-viscosimeter) were measured before and after a clofibrate therapy (2 × 1 g/day) lasting for 7 to 9 weeks. Serum and plasma viscosity was lowered significantly in both types II and IV. The apparent viscosity decreased at shear rate 46 s−1 in type IV, whereas it remained unchanged in type II. Moreover, there exists a qualitative correlation between changes in serum viscosity and changes in lipoprotein concentration. Fibrinogen concentration remained unaltered.
    Notes: Zusammenfassung Bei Patienten mit primärer Hyperlipoproteinämie (23 Patienten Typ II a und b, 13 Patienten Typ IV) wurden die Veränderungen der Lipoproteinkonzentrationen (Lipidanteile), der Fibrinogenkonzentrationen, der kinematischen Serum- und Plasmaviskosität (im Kapillar-Viskosimeter) sowie der relativen scheinbaren Viskosität (Platte-Kegel-Viskosimeter) bei Schergrad 46 s−1 und 115 s−1 vor und nach einer 7- bis 9wöchigen Clofibrattherapie (2 × 1 g/die) gemessen. Art und Ausmaß der Lipoproteinveränderungen entsprachen den Erwartungen. Die Serum- und Plasmaviskosität wurde bei beiden Typen signifikant gesenkt. Eine signifikante Minderung der scheinbaren Viskosität konnte bei dem Schergrad 46 s−1 für den Typ IV gesichert werden, wohingegen der Typ II unbeeinflußt blieb. Weiterhin konnte ein enger qualitativer Zusammenhang zwischen den Änderungen der Lipoproteinkonzentrationen und den Änderungen der Serumviskosität gezeigt werden. Veränderungen der Fibrinogenkonzentration waren nicht zu sichern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476981
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  • 10
    Electronic Resource
    Electronic Resource
    Blutviskosität und Erythrozytenflexibilität bei primären Hyperlipoproteinämien (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 271-273 
    Details
    ISSN: 1432-1440
    Keywords: Hyperlipoproteinemia ; Blood viscosity ; Red cell deformability ; Hyperlipoproteinämie ; Blutviskosität ; Erythrozytenflexibilität
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei Patienten mit einer primären Hyperlipoproteinämie (Typ IIa, IV, IIb) wurde mit einem Ubbelohde-Kapillarviskosimeter, mit einem Wells-Brookfield-Platte-Kegel-Viskosimeter und einem Nuklepore-Filtrationsgerät die Serum- und Plasmaviskosität, scheinbare und relative scheinbare Blutviskosität sowie die Erythrozytenflexibilität bestimmt. Alle Meßgrößen unterschieden sich signifikant von denen eines normolipidämischen Kontroll-Kollektivs: Die Viskositätswerte waren beim Typ IIb am stärksten, beim Typ IIa am schwächsten erhöht, während die Erythrozytenflexibilität unabhängig vom Typ vermindert war.
    Notes: Summary In patients with primary hyperlipoproteinemia (types IIa, IV, IIb) we determined by means of a Wells-Brookfield plateconeviscometer and an Ubbelohde capillary-viscometer the serum-, plasma-, apparent and relative apparent blood viscosity as well as the red cell deformability with a filtration technique. All parameters were found to be significantly changed in comparison to those of a normolipidemic control-group: The viscosity values of type IIb showed the greatest increase and of type IIa the smallest, while the red cell deformability was reduced in all types to the same degree.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01489172
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