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  • 1
    Electronic Resource
    Electronic Resource
    EFFECTS OF N-METHYLAMINOETHANOL, AND N,N-DIMETHYL-AMINOETHANOL IN THE DIET OF PREGNANT RATS ON NEONATAL RAT BRAIN CHOLINERGIC AND PHOSPHOLIPID PROFILE (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Pregnant rats were fed for 15 days predelivery until 15 days postpartum a choline (Ch)-deficient diet (CD diet) or a CD diet supplemented with 0.8% Ch-CI (CS), 1%N-methylaminoethanol (MME) or 1%N,N-dimethylaminoethanol (DME). Gestation and parturition of the pregnant rats proceeded normally. However, all the pups born of dams fed the MME diet, and most of those born of dams fed the DME diet, died within 36 h of birth. No histological or cytological alterations were detected in the brain of the pups. Levels of Ch and acetylcholine (ACh) were elevated in the brain of pups born of dams fed the MME and DME diets, but not the CS diet. The content of total phospholipids in the brain of the pups was not altered by the diet fed to the dams. However, the phosphatidyl-Ch and phosphatidylaminoethanol (PAE) contents in the brain of the MME- and DME-exposed pups were markedly reduced. At the same time, significant amounts of DME, phosphatidyl-N-monomethylaminoethanol (PMME) and of phosphatidyl-N,N-dimethylaminoethanol (PDME) were present in the same brain areas. These results are evaluated and discussed in terms of providing a cause for the death of the MME- and DME-exposed neonatal rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb10452.x
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  • 2
    Electronic Resource
    Electronic Resource
    Meningoencephalitis due to acanthamoeba SP (1977)
    Springer
    Acta neuropathologica 37 (1977), S. 183-191 
    Details
    ISSN: 1432-0533
    Keywords: Acanthamoeba ; Naegleria ; Meningoencephalitis ; Granulomatous ; Free-living amebas ; Cysts ; Trophozoites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Amebic Meningoencephalitis (AM) and Primary Amebic Meningoencephalitis (PAM) are infectious diseases essentially confined to the Central Nervous System (CNS) and caused by free-living amebas of the genusAcanthamoeba (A.) andNaegleria (N.) respectively. AM due toA. sp. (Acanthamoeba castellanii andAcanthamoeba culbertsoni) have been reported in chronically ill debilitated individuals, some of them under immunosuppressive therapy, or in immunologically impaired patients without a history of recent swimming in contrast to cases due toN.sp. which usually occurs in healthy, young individuals with a recent history of swimming in man-made lakes or heated swimming pools. AM due toA.sp. is characterized by a subacute or chronic granulomatous meningoencephalitis involving mainly the midbrain, basal areas of the temporal and occipital lobes and posterior fossa structures. CNS lesions in AM are perhaps secondary and the portal of entry in humans is probably from the lower respiratory tract, genitourinary system or skin reaching the CNS by hematogenous spread. The predominant host reaction is usually composed of lymphocytes, plasma cells, monocytes and multinucleated foreign body giant cells. Necrosis is moderate and hemorrhage scant or absent. Cysts as well as trophozoites may be seen within the CNS lesions. PAM is due toNaegleria fowleri and is characterized by an hemorrhagic necrotizing meningoencephalities with an acute inflammatory response. Only trophozoites are found in lesions. The portal of entry is through the olfactory neuroepithelium. CNS tissues fixed in formalin may be used for further identification and taxonomical classification of the causative protoza using immunofluorescent antibody techniques (IFAT) and electron microscopic methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00686877
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  • 3
    Electronic Resource
    Electronic Resource
    Extraocular muscles light microscopy and ultrastructural features (1976)
    Springer
    Acta neuropathologica 34 (1976), S. 237-253 
    Details
    ISSN: 1432-0533
    Keywords: Strabismus ; Extraocular muscles ; Hirano bodies ; Ultrastructure ; Luse bodies ; Leptomeres
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty extraocular muscles (EOM) from 20 patients were evaluated by light microscopy (LM), electron microscopy (EM), and enzyme histochemistry (EZH). Twenty-one EOM were obtained from 13 patients with strabismus, 9 EOM from 4 patients undergoing eye surgery for other reasons and from 3 autopsy cases. One μm thick sections revealed marked variation in muscle fibre shape and size and in myofibrillar structure; also noted were small, hypertrophied, whorled, and ringbinden fibres. Dense and granular material in the central portion of some fibres and sarcomere disruption in 2–3 μm sections was observed. EZH revealed the absence of the classical mosaic pattern usually found in skeletal muscles. ATPase studies were inconsistent and did not correlate with the expected reciprocal activity of NAD-H diaphorase, particularly on the large fibres. Ultrastructural features consisted of vacuoles within myofilament bundles, “smearing” of Z bands, and “nemaline rods”. Occasional myelin figures and lipid-like droplets were observed in subsarcolemmal spaces, associated with scattered clusters of glycogen granules. Abnormal mitochondria and subsarcolemmal inclusions of dense and granular material were conspicuous. “Leptomeric” profiles, “Zebra bodies”, or “striated bodies” were noted in 8 EOM's, and an Hirano body was found in 1. The intramuscular nerves contained structures resembling “Luse bodies” in 7 cases. These observations suggest that EOM from individuals with and without strabismus possess unique structural characteristics suggestive of developmental and morphological disarrangement of contractile elements. Some of these changes might play a role in the pathogenesis of strabismus and in the development of clinical symptoms. These features are significantly different from striated skeletal muscle. Therefore the criteria used in the pathological evaluation and diagnosis of skeletal muscle disorders cannot be unequivocally applied to EOM investigations. These data establish the necessity to determine histological norms, ultrastructural patterns, and develop new enzyme histochemistry criteria for the evaluation of EOM. Only then can an acceptable comparison of EOM and skeletal muscle be made.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688678
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  • 4
    Electronic Resource
    Electronic Resource
    Malignant fibrous mesothelioma (1975)
    Springer
    Acta neuropathologica 33 (1975), S. 173-177 
    Details
    ISSN: 1432-0533
    Keywords: Mesothelioma ; Pleura ; Metastases ; Brain ; Ultrastructure ; Asbestos
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A malignant fibrous mesothelioma in a 52 year old white man arising from the left parietal pleura associated with lupus erythematosus with metastases to brain and liver is reported. Asbestos bodies were found in digested pulmonary tissue but none in the primary or metastatic lesions. Light microscopic and ultrastructural studies suggest that this tumor contains mesothelial or endothelial cells, some of which revealed fibroblastic features while others disclosed epitheloid characteristics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687543
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  • 5
    Electronic Resource
    Electronic Resource
    Extraocular muscles: Morphogenetic study in humans light microscopy and ultrastructural features (1977)
    Springer
    Acta neuropathologica 38 (1977), S. 87-93 
    Details
    ISSN: 1432-0533
    Keywords: Human fetal muscle ; Electron microscopy ; Motor end-plate ; Extraocular muscles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The development of human extraocular muscles (EOM) was studied in a series of fetal specimens (12–24 weeks gestation). EOM were evaluated by enzyme histochemistry (EZ) (NADH and ATPase), by differential phase contrast microscopy (DPC) and electron microscopy (EM). In the early fetus (14 weeks), there was no clear-cut sub-division into fibre types. A uniform histochemical reaction was seen with NADH while ATPase showed light and dark myotubes. Myotubes contained large central nuclei, prominent eccentric nucleoli, abundant glycogen granules, free ribosomes, numerous mitochondria, and dense and looser bundles of myofilaments. Mesenchymal cells undergoing mitosis and fibroblasts with prominent stacks of rough endoplasmic reticulum were scattered within endomysium. Mast cells with well formed cytoplasmic granules were found as early as 18–24 weeks. The same specimens by DPC showed differentiation into at least 4 different fibre types at 12 weeks. All the intramuscular nerves at 12–16 weeks were composed of unmyelinated fibres. At 18 weeks, myelinated axons were present. Morphologically immature end-plates devoid of junctional folds were found at 12 weeks. The motor innervation of some EOM appears to be derived from more than one axon (multiple innervated fibres). At 18 weeks gestational age, differentiation into fibre types became apparent by enzyme histochemistry. These histochemical and morphological findings suggest that morphologically mature endplates are not prerequisites for differentiation into muscle fibre types.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688553
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  • 6
    Electronic Resource
    Electronic Resource
    Quantitative inheritance and barriers to crossability in Cicer arietinum L. (1979)
    Springer
    Theoretical and applied genetics 55 (1979), S. 5-16 
    Details
    ISSN: 1432-2242
    Keywords: Genetic barriers ; Cicer arietinum ; Diallel analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Three different diallel crosses were studied in Cicer arietinum; two of size 6×6, one within each of the two botanical groups ‘macrosperma’ and ‘microsperma’ of the cultivated subspecies, and one of 9×9 involving lines covering most of the morphological variation of chickpea. Barriers to crossability present neither a botanical nor a geographical pattern, being probably a direct consequence of interactions between genotypes. The genetic systems of twelve quantitative characters were analysed. Full dominance in a negative sense (small values dominant) is shown by leaflet length, width and shape index, rachis length, leaflet density on the rachis and pod length. Full dominance in a positive sense is shown by seeds per pod. Overdominance (in a positive sense) is evident for pods, seeds and yield per plant. Weak reciprocal differences were manifested by pod length, and pods, seeds and yield per plant. The system controlling number of leaflets per leaf is not clear. Dominance of ‘primitive’ over ‘selected’ characters seems to be the rule. As far as the environmental effects have permitted the analysis, no differences in genetic systems were observed between botanical groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282970
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  • 7
    Electronic Resource
    Electronic Resource
    Penicillium fagi sp. nov., isolated from beech leaves (1978)
    Springer
    Mycopathologia 63 (1978), S. 57-59 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A description is presented of a new species of Penicillium, isolated from fallen beech (Fagus silvatica) leaves over an andosol in the Spanish province of Navarra. Its main characteristics suggest its location within the Penicillium roqueforti series of the Biverticillata-Asymmetrica-Velutina subsection and the name of Penicillium fagi is proposed. The species is characterized by the deep blue colour of the reverse, the conspicuous wartness throughout the penicilli from the conidiophore to the tip of metulae, and the small conidia (2.0 to 2.5 μ diameter).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00473161
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  • 8
    Electronic Resource
    Electronic Resource
    Estudio de la patogenicidad de conidiobolus Coronatus en animales de experimentacion (1978)
    Springer
    Mycopathologia 66 (1978), S. 59-65 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Resumen A partir de una cepa de Conidiobolus coronatus aislada de Aenolamia postica, se inocularon 152 ratones, 42 cobayos y 47 hamsters por vías intraperitoneal (IP), subcutánea (SC), intratraqueal y por escarificación en la mucosa oral; cada animal se inoculó 3 veces a intervalos de una semana. Los animales se sacrificaron a los 1, 8, 15, 45 y 225 días de la primera inoculación, haciéndose estudios de alteraciones macroscópicas (nódulos, abscesos, adherencias), exámenes directos, cultivos e histopatología. Las alteraciones macroscópicas de los tejidos fueron las más frecuentes y todas evolucionaron a la curación espontánea. Los animales presentaron un mayor múmero de estudios positivos cuando se inocularon por vía IP y SC. Los estudios histopatológicos hechos al 1° y 8° día, demostraron un infiltrado inflamatorio agudo y filamentos fúngicos bien conservados; a los 15 días se observaron granulomas con células gigantes y filamentos fragmentados en desintegración; a los 45 y 225 días se observó una reacción de fibrosis sin filamentos fúngicos. Se consideró que en ningún caso se logró reproducir la rinoentomoftoromicosis y de acuerdo a éstos resultados se estima que esta cepa no tiene patogenicidad o bien ésta es muy baja.
    Notes: Abstract The pathogenicity of a strain of Conidiobolus coronatus isolated from Aenolamia postica was investigated in 152 mice, 42 guinea pigs and 47 hamsters. Four routes of inoculation were used: intraperitoneal, subcutaneous, intratracheal and scarification in the oral mucosa. Each animal was inoculated 3 times at 3 week intervals. Animals were sacrificed at 1, 8, 15, 45 of 225 days after the first inoculation. Observations of macroscopic lesions (nodules, abscesses, adhesions, etc.) direct examinations, cultures and histopathological studies of different tissues were performed. The aforementioned lesions of tissue were the most frequently found and all of them were resolved by spontaneous cure. The animals inoculated intraperitoneally and subcutaneouslly presented the highest number of positive results. The histopathological features at the 1st and 8th days after inoculation showed an acute inflamatory infiltrate with well preserved fungus filaments; at the 15th day granulomas with giant cells were observed containing fragmented and disintegrated fungal hyphae; at the 45th and 225th days a fibrosis reaction was observed and no fungal filaments, could be found. In no animal was rhinoentomophthoromycosis never reproduced, and according to these results it is considered that either this strain is not a pathogen or its pathogenicity is very low.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429594
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  • 9
    Electronic Resource
    Electronic Resource
    Three new species of penicillium (1978)
    Springer
    Mycopathologia 66 (1978), S. 77-82 
    Details
    ISSN: 1573-0832
    Keywords: Fungus taxonomy ; New species ; Penicillium ; Aerobiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Three new species of microfungi belonging to the genus Penicillium Link ex Fries are described and illustrated. All but one have been isolated from the atmosphere of las Palmas, capital city of the island of Gran Canaria (Canary Islands, Spain). They clearly differ from all species of the genus described so far and are, therefore, described and proposed as new species: Penicillium hispanicum sp. nov., Penicillium grancanariae sp. nov., and Penicillium palmensis sp. nov.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429597
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  • 10
    Electronic Resource
    Electronic Resource
    The fine structure of blood vessels of the telencephalic germinal matrix in the human fetus (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 149 (1977), S. 439-452 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Blood vessels of the human telencephalic germinal matrix during the tenth through the twenty-second week of gestation have been examined by light and electron microscopy. In all fetuses studied the ependymal and sub-ependymal zones of the germinal matrix have a prominent vascular network. During the tenth and twelfth weeks of gestation, the endothelial cells are plump and display numerous organelles, junctional complexes, conspicuous luminal microvilli and stub-like abluminal projections. Coated and micropinocytotic vesicles were found both in the cytoplasm and on luminal and abluminal surfaces. In endothelial cells intracytoplasmic, membrane-limited, rod-shaped bodies were frequently observed. These bodies have been linked to endothelial thromboplastic and clotting activities and related to abnormal clotting status. Their role in the pathogenesis of subependymal germinal matrix hemorrhage in premature infants remains unknown. Pericytes apposing the endothelial cells were recognized in all gestational periods. The endothelial basal lamina and astrocytic end-feet are ill defined, and the extracellular space is pronounced. By the fifteenth and seventeenth weeks of gestation the endothelial cells are still large and now possess more numerous luminal microvilli and abluminal projections. At this stage the pericytes, basal lamina and astrocytic end-feet are all well developed, resulting in a decrease in the surrounding extracellular space. By the twenty-second week the endothelial cells possess few luminal and abluminal projections and the associated basal lamina, glia, pericytes and extracellular compartment appear mature. The relationship of the germinal matrix vasculature to the pathogenesis of subependymal hemorrhage is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001490402
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