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  • 1970-1974  (15)
  • 1965-1969  (7)
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Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 52 (1965), S. 500-500 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 52 (1965), S. 188-189 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 61 (1974), S. 328-328 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Naturwissenschaften 60 (1973), S. 55-55 
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] TISSUE-SPECIFIC anti-mitotic substances, now known as chalones1, have been extracted from a number of tissues, and especially well known are the epidermal and granule -cytic chalones2'3. Although it is tissue-specific the epidermal chalone is not species-specific4. The various chalones evidently ...
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 66 (1965), S. 536-540 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Pregnant gold hamsters received di-ethylnitrosamine (NÄNA) subcutaneously (2–14 mg; daily dose 2 mg) in the second half of gestation. Twenty-five weeks after birth of the litter multiple tracheal papillomata were found in 42% of the young. In addition, a diffuse squamous epithelial cell metaplasia was disclosed in the region of the tracheobronchial tree. A hepatotoxic effect (cirrhosis) was observed 25 weeks after birth in 68% of the young. DÄNA, therefore, crossed the placenta in the fetuses.
    Notes: Zusammenfassung Trächtige Goldhamster erhielten in der 2. Hälfte der Tragzeit Diäthylnitrosamin (DÄNA) (2–14 mg, Tagesdosis 2 mg) subcutan verabreicht. 25 Wochen nach dem Wurf fanden sich bei 42% der Jungen zum Teil multiple Trachealpapillome. Darüber hinaus zeigte sich eine diffuse Plattenepithelmetaplasie im Bereich des Tracheobronchialbaumes. Eine leberschädigende Wirkung (Cirrhose) wurde 25 Wochen nach dem Wurf bei 68% der Tiere beobachtet. DÄNA gelangt also durch die Placenta an den Fetus.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 68 (1966), S. 321-325 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Adult golden hamsters were treated with Trenimon, Bayer E 39 or Sanamycin 18–20 days after transplantation of KG-13-plasmocytoma. Cytostatic treatment had no effect on survival time. Treatment with Bayer E 39 or Sanamycin showed involution of tumors and normalisation of blood proteins. Trenimon treatment had no effect on tumor growth and blood proteins; there was no difference between the Trenimon-group and untreated controls.
    Notes: Zusammenfassung 18–20 Tage nach Transplantation des KG-13-Plasmocytoms auf ausgewachsene Goldhamster wurden diese mit Trenimon, Bayer E 39 oder Sanamycin behandelt. Die Prüfung der Überlebenszeit erbrachte keinen signifikanten Unterschied zwischen Kontrolltieren und behandelten Versuchstieren. Nach Behandlung mit Bayer E 39 und Sanamycin erfolgt neben der Rückbildung der Tumoren die Normalisierung der Bluteiweißwerte. Die Behandlung mit Trenimon hat keinen Einfluß auf das Tumorwachstum und Bluteiweißbild. Solche Tiere zeigen das gleiche Verhalten wie tumortragende, unbehandelte Kontrollen.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 82 (1974), S. 153-158 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die primär multiple Carcinogenese durch DBN wurde systematisch am Modell des Goldhamsters untersucht. Nach subcutaner wie auch nach intragastrischer Gabe fanden sich gleichzeitig Tumoren in Respirationssystem und in der Harnblase. Überlebenszeit, Tumorhäufigkeit und Latenzzeit waren abhängig von der Dosis. Papillome und Plattenepithelcarcinome zeigten sich in den Nasenhöhlen; papilläre Polypen wurden meist in Larynx, Trachea und Stammbrochien beobachtet, in den Lungen fanden sich gemischte und kombinierte Carcinome. Die Harnblase zeigte Übergangsepithelpapillome und -Carcinome.
    Notes: Summary The hamster was used as a model for systematic studies in primary multiple carcinogenesis induced by DBN. After subcutaneous and intragastric treatment, neoplasms were simultaneously found in the respiratory system and in the urinary bladder. A dose dependent effect was seen for survival, tumor incidence and latency. Papillomas and epidermoid carcinomas were found in the nasal cavities; papillary polyps were mainly found in the larynx, trachea and stem bronchi whereas mixed and combined carcinomas were observed in the lungs. The urinary bladder showed transitional cell papillomas and carcinomas.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 82 (1974), S. 233-238 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Swiss-Mäuse erhielten intraperitoneal entweder DMN oder DEN oder beide Substanzen simultan, wodurch sich vergleichsweise zu den Kontrollen eine höhere Lungentumorrate ergab: Während DMN behandelte Tiere gehäuft Carcinome zeigten, wurden nach simultaner DMN + DEN-Behandlung vorwiegend atypische Adenome bzw. nach DEN-Gaben Adenome beobachtet. Die Behandlung nur mit DMN führte bei den Swiss-Mäusen noch zu retroperitonealen vasculären Neoplasmen und zu einigen Nierenadenomen. Papillome des Vormagens fanden sich bei Tieren der DEN bzw. DMN + DEN-Versuchsgruppen. Die Anzahl der nachgewiesenen Lymphome in allen carcinogen-behandelten Tieren bewegt sich im Bereich der Spontantumorrate
    Notes: Summary Swiss mice were treated i.p. with DMN and DEN either alone or simultaneously. In comparison to controls, the lung tumour incidence was increased in the carcinogen treated groups. Whereas DMN frequently caused lung carcinomata, DEN treated mice showed mainly lung adenomata; atypical adenomata were mostly found after simultaneous applications of DMN and DEN. Retroperitoneal vascular tumours and kidney adenomata were observed only after DMN treatment. Forestomach papillomata were seen in the groups receiving DEN and DMN + DEN. The rate of malignant lymphomata for all carcinogen treated mice fluctuated within the realm of a spontaneous tumour rate.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 79 (1973), S. 98-107 
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die kombinierte Verabreichung von Methylcholanthren (MCA) (intragastrisch) und Dimethylnitrosamin (DMN) (intraperitoneal) führte bei Swiss-Mäusen zu erhöhter Tumorrate bei verkürzter Latenzzeit im Vergleich zu Tieren, die jeweils nur mit einer der beiden Substanzen behandelt wurden. In der MCA+DMN-Gruppe fanden sich vermehrt Lungencarcinome, Neoplasmen der Nieren und Lymphome. Bei den Tieren der DMN-Gruppe zeigten sich gehäuft Gefäßtumoren. Die Befunde der MCA + DMN-Gruppe werden als syncarcinogene Wirkung der Substanzen diskutiert.
    Notes: Summary The combined application of MCA (i.g.) and DMN (i.p.) to Swiss mice resulted in an increased incidence of tumors and in a decreased tumor latency, compared with the animals treated with each compound alone. In the MCA+DMN group the rate of lung carcinomas and neoplasms of the kidney was found to be significantly enhanced, while the DMN group showed an increase of vascular tumors. In the MCA group malignant lymphomas were seen more frequently than in the other groups. The findings concerning the lung and kidney were interpreted as a syncarcinogenic effect of the combined application of MCA + DMN.
    Type of Medium: Electronic Resource
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