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  • 1970-1974  (3)
  • 1960-1964  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 10 (1963), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 19 (1972), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Four catecholamines injected into the cerebral ventricles increased the content of cyclic adenosine 3′,5′-monophosphate (cAMP) in vivo in the whole brain of rats. The highest rise (2.6-fold) was measured 2 min after an injection of 100 μg epinephrine. Isoproterenol and norepinephrine were less active and dopamine hardly increased the cAMP level. These results are compatible with the view that physiological actions of catecholamines in the nervous system may be mediated by an increase of CAMP.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 274 (1972), S. 192-197 
    ISSN: 1432-1912
    Keywords: Brain Serotonin ; PGO-Spikes ; Methiothepin ; Serotonin Antagonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Methiothepin (1-[10,11-dihydro-8-(methylthio)dibenzo[b,f] thiepin-10-yl]-4-methylpiperazine maleate), a representative of a new class of neuroleptics, is shown to be an antagonist of 5-hydroxytryptamine (5-HT) at receptors in the CNS. The neuropharmacological evidence was obtained by observing its effects on ponto-geniculo-occipital (PGO) spikes induced in curarized cats by either the benzoquinolizine Ro 4-1284 or p-chlorophenylalanine. Methiothepin a) increased the number of drug-induced spikes, b) antagonized the inhibitory action of 5-HTP and LSD on the spikas, and c) induced PGO-spikes by itself in untreated animals. The turnover of 5-HT in the rat brain was accelerated by methiothepin as indicated by virtually unaltered 5-HT levels, an increase of 5-hydroxyindole acetic acid, an enhancement of the 5-HT increase induced by a MAO inhibitor and by an increase of tryptophan levels in the brain.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 18 (1962), S. 411-412 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung N-(DL-Seryl)-N′-(2,3,4-trihydroxybenzyl)hydrazin (Ro 4-4602) bewriktin vitro starke Hemmung der Decarboxylase, die durch Pyridoxal-5′-phosphat nicht und durch Dialyse nur wenig vermindert werden kann. Nach i.p. Applikation der Substanz kommt es zu starker Verminderung der Decarboxylase-Aktivität und zu mässiger Herabsetzung von 5-Hydroxytryptamin und Noradrenalin in verschiedenen Organen. Monoaminoxydase des Gehirns wirdin vivo durch Ro 4-4602 nicht beeinflusst.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 28 (1972), S. 845-846 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Die subzellulären Organellen, welche in Blutplättchen von Ratten und Meerschweinchen 5-Hydroxytryptamin und Adenosin-5′-triphosphat speichern enthalten bis über 100 Mal mehr cyclisches Adenosin-5′-monophosphat (cAMP) als die ganzen Plättchen und die übrigen subzellulären Fraktionen. Durch die Speicherung in subzellulären Organellen kommt es möglicherweise zu einer biologischen Inaktivivierung von cAMP in den Plättchen.
    Type of Medium: Electronic Resource
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