ISSN:
1432-2013
Keywords:
Distal Potassium Transport
;
Distal Sodium Transport
;
Tubular Effects of Ouabain
;
Luminal Potassium Transport
;
Peritubular Potassium Transport
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Recollection micropuncture experiments were carried out on superficial distal rat tubules before and after the infusion of ouabain (0.3 ml h−1 of a 1.37×10−2 M solution) into the renal artery. Fluid was analyzed for14C-inulin, sodium (Na) and potassium (K). Experiments were done in rats on a low-potassium diet as well as in rats on a normal potassium intake. Ouabain induced natriuresis and kaliuresis. These diuretic effects were not restricted to the site of injection since similar but weaker effects were observed in the contralateral kidney. The effects of ouabain upon distal tubular electrolyte transport consisted in depression of sodium transport and an elevation of potassium concentrations in distal tubular fluid. The distal potassium effect in initially non-diuretic animals is considered to be due to partial inhibition of active potassium uptake across the luminal cell membrane of distal tubule cells. In animals reabsorbing potassium from the tubule lumen ouabain induceds a fall in net potassium reabsorption whereas in animals secreting potassium along the distal tubule it augments net potassium transfer from the peritubular to the luminal fluid.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00586621
Permalink
