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  • 1965-1969  (30)
  • Organic Chemistry  (19)
  • Polymer and Materials Science  (10)
  • Chlorpromazin  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Zur Wirkung des Chlorpromazin auf das Lipopolysaccharid-Fieber des Kaninchens (1968)
    Springer
    Clinical and experimental medicine 146 (1968), S. 125-138 
    Details
    ISSN: 1591-9528
    Keywords: Thermoregulation ; Fever ; Chlorpromazine ; Thermoregulation ; Fieber ; Chlorpromazin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In 160 Versuchen am Kaninchen wurde die Wirkung von Chlorpromazin, das besonders in den für die Wärmeregulation wichtigen zentralen Gebieten des Hypothalamus und der Formatio reticularis angereichert wird, auf die normale Körpertemperatur und die Fieberreaktion nach Gabe von Lipopolysacchariden gramnegativer Bakterien untersucht. Gemessen wurden die Rectal- und Ohrtemperatur, die Atem- und Herzfrequenz. Es ergab sich: 1. die Rectaltemperatur des unbeeinflußten Kaninchens wird bei einer Umgebungstemperatur von 22° C in Abhängigkeit von der Dosis gesenkt, 2. das Lipopolysaccharid-Fieber läßt sich durch Vorgabe von mehr als 1 mg/kg Chlorpromazin abschwächen oder unterdrücken, 3. die Reaktion in Empfängertieren durch Plasmaübertragung von fiebernden Spendertieren kann drei verschiedene Verlaufsformen ergeben: eingipflige, zweigipflige und afebrile. Eine Beziehung zur Größe des Spendertierfiebers bestand dabei nicht. Die Ergebnisse werden hauptsächlich durch die zentralen Angriffspunkte des Chlorpromazins erklärt.
    Notes: Summary Chlorpromazine concentrates particularly in that central regions of the CNS important for the thermoregulation, in the hypothalamus and the formatio reticularis. Therefore in 160 experiments on rabbits the effect of chlorpromazine was tested at the normal body temperature and the fever reaction after medication of lipopolysaccharides (LPS) from gramnegative bacteria. Measured were the rectal- and ear-temperature, the heart- and respiration-frequency. It resulted that: 1. the rectal temperature of untreated rabbits at environmental temperature of 22°C ± 2°C is lowered, dependant on the dose, 2. the LPS-fever is diminished or suppressed after premedication of 〉 1 mg/kg chlorpromazine, 3. the reaction in the recipient animal may proceed in three different types of fever: mono- and biphasic curves and an afebrile one. A relation to the height of fever of the donor animal was not existant. Analogue to other experiments with central acting pharmaca and local cerebral temperature-stimulations in the area of the anterior hypothalamus as well as considering the distribution of chlorpromazine in the CNS these results are explained by specific effects of chlorpromazine in the hypothalamus and the formatio reticularis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02043778
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  • 2
    Electronic Resource
    Electronic Resource
    Note on the continuous measurement of polymerization rates with a recording dilatometer (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 12 (1968), S. 1803-1805 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1968.070120732
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  • 3
    Electronic Resource
    Electronic Resource
    Sulfonium polymers derived from Ar-vinylbenzyl chloride. I. Exploratory study of the preparation and properties of the monomers and polymers (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 13 (1969), S. 721-744 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Although sulfonium salts are well known, polymeric sulfonium salts seldom have been mentioned in the chemical literature. This paper describes exploratory work in the preparation of various sulfonium monomers and polymers from ar-vinylbenzyl chlorides (ortho and para isomers). These chlorides - particularly the para isomer - reacted readily with 2,2′-thiodiethanol and water to yield the corresponding ar-vinylbenzyl sulfonium chloride monomers in aqueous solution. The odorless, reactive monomer mixture polymerized readily with persulfate or hydroperoxide catalysts; however, polymerization could be inhibited with cupric salts. Copolymerization with trimethyl(ar-vinylbenzyl)ammonium chloride was random. In copolymerization with acrylamide or acrylonitrile, the sulfonium monomer was more reactive. Analogous sulfonium monomers were made by reaction of ar-vinylbenzyl chlorides with various sulfides. In general, all the sulfonium monomers yielded homopolymers which were fairly stable in aqueous solution in the absence of strongly nucleophilic agents which would attack the sulfonium groups. However, when dried at room temperature the polymers would crosslink; and when heated, the polymers became hydrophobic also. Scrambling of the sulfonium group substituents during drying, and nucleophilic displacement reactions by chloride ion during heating were likely explanations. The high cationic charge on the polymers made them substantive to cellulose fibers. This property, when coupled with high nucleophilic reactivity of the sulfonium groups with the carboxylate sites of the pulp or other anionic counterious during drying and heating, made the polymers very effective as beater additives for imparting wet strength to paper.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1969.070130412
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  • 4
    Electronic Resource
    Electronic Resource
    Heterogeneous polymer systems. V. Viscosity behavior of polymerizing solutions of rubber in styrenePart of a paper presented at the Symposium on Polymer Modification of Rubbers and Plastics, Chicago ACS Meeting, Sept. 10-15, 1967. (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 13 (1969), S. 2735-2736 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1969.070131220
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  • 5
    Electronic Resource
    Electronic Resource
    Ein perlförmiges cellulosegel für die chromatographie (1968)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 114 (1968), S. 263-274 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Rigid and chemically resistant 30-300 μm beads of cellulose gel can be prepared by precipitation of dispersed solutions of cellulose with organic acids. The pores of these particles have generally diameters of some hundreds of nanometers depending on concentration of cellulose in the starting solution. Mainly, gels obtained from 2, 6 and 10 percent cellulose containing SCHWEIZER reagent by regeneration with benzoic acid in benzene have been investigated in gel chromatography of E.coli bacteria, dextranes, proteins and benzyl alcohol. Gel beads from 6 and 10 percent SCHWEIZER reagent are appropriate for separating substances of mol. wt. from 104 to 107 with water as an eluent. Acetic acid instead of benzoic acid as regenerating agent causes shrinking of the pores next the surface of the particles.
    Notes: Durch Ausfällen mit organischen Säuren lassen sich aus verschiedenen in Benzol emulgierten Celluloselösungen mechanisch und chemisch widerstandsfähige Perlen von 30 bis 300 μm Durchmesser gewinnen. Sie haben Poren von durchschnittlich einigen hundert nm Weite, deren mittlerer Durchmesser von der Cellulosekonzentration in der Lösung abhängt. Hauptsächlich wurden die Gele aus 2, 6 und 10% cellulosehaltiger SCHWEIZER-Lösung, welche mit benzolischer Benzoesäure regeneriert waren, in ihrer Fähigkeit zur gelchromatographischen Trennung von E.coli-Bakterien, Dextranen der Molgewichte von 2·105 bis 7·106, verschiedenen Proteinen und Benzylalkohol im. wäßrigen System untersucht. Besonders die aus 6- und aus 10-proz. Lösung erhaltenen Gelperlen eignen sich zur Trennung von Substanzen im Molekulargewichtsbereich von 104 bis 107. Die hygroskopische Essigsäure, statt Benzoesäure als Fällungsmittel bewirkt eine Schrumpfung, d.h. Porenverengung in der Nähe der Oberfläche.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1968.021140122
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  • 6
    Electronic Resource
    Electronic Resource
    Dynamic viscoelastic properties of solutions of shear-degraded deoxyribonucleic acid (1967)
    New York : Wiley-Blackwell
    Biopolymers 5 (1967), S. 123-130 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Calf thymus and salmon sperm deoxyribouncleie acid were degraded by high-shear stirring to molecular weights M in the range of 1.3-3.2 × 106 and purified by chromatography on methylated bovine serum albumin. Dynamic viscoelastic properties of the fragmented products, in aqueous glycerol solutions in the concentration range of c = 0.003-0.01 g./ml., were investigated with the apparatus of Birnboim and Ferry. At values of the product cM higher than 4 × 103, the frequency dependence of the components of the complex shear modulus, G′ and G″, displayed a plateau region in which G′ 〉 G″ - ων1ηS, similar to that observed in concentrated solutions of coiling polymers where it is attributed to an entanglement network (ω is radian frequency, ν1 volume fraction of solvent, and η8, solvent viscosity). The width of this plateau region on the logarithmic frequency scale is given by Δ = 3.8 (log cM - 3.56). At lower values of cM, the frequency dependence is intermediate between those predicted by the theory of Zimm for flexible coiled macromolecules and by the theory of Kirkwood and Auer for rods. Fitting to the Zimm theory gives highly discrepant values for molecular weights, while fitting the low-frequency end of the dispersion to the Kirkwood-Auer theory gives reasonable agreement for both molecular weight and rotary diffusion coefficient. It is concluded that the helical fragments appear as nearly rigid rods in their behavior at very low frequencies, but at higher frequencies reveal substantial bending flexibility.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1967.360050112
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  • 7
    Electronic Resource
    Electronic Resource
    Cinobufaginol Über Krötengifte, 32. Mitteilung31. Mitt. vgl. E. Iseli et al. [1] (1966)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 49 (1966), S. 1243-1246 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Aufklärung der Konstitution von Cinobufaginol (= Substanz G aus Ch'an Su) mit Hilfe der Protonenresonanzspektroskopie.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19660490404
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  • 8
    Electronic Resource
    Electronic Resource
    Die Glykoside der Blätter von Isoplexis isabelliana (WEBB) MASF.Für diese Art des Kanarischen Fingerhuts ist früher [1] [2] die Bezeichnung Digitalis canariensis L., var. isabelliana (WEBB) LINDINGER verwendet worden. Die hier benützte Nomenklatur ist der Arbeit von WERNER [3] entnommen worden.. 3. Mitteilung2. Mitteilung: [2]. (1967)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 50 (1967), S. 1336-1366 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The isolation, characterisation and chemical investigation of the cardiac glycosides of the dried leaves of Isoplexis isabelliana (WEBB) MASF. are described. 7 glucosides B, D, E, J (monoside), K, M, and 1 (monoside) could be obtained in homogenous form, 3 others were mixtures (“A” = A1 + A2, “C” = C1 + C2, and “G” = G + K). The substances B (gluco-evatromonoside), D (cheiroside A), E (digitoxigenin-glucosido-6-deoxyglucoside), J (digitoxigenin glucoside), and M (digitalinum verum) could be identified with known substances. The new glycosides are derived from 3 genins: digitoxigenin, uzarigenin, and xysmalogenin, which are directly bound to one of the following sugars: 6-deoxyglucose, 2-O-acetyl-6-deoxy-D-glucose, 2,6-dideoxy-D-arabinohexose (= D-canarose), and 2,6-dideoxy-D-ribohexose (= D-digitoxose), terminated by a glucose unit. -Canarobiose, a new crystalline disaccharide of D-glucose and D-canarose, has also been obtained. -Apart from these cardiac glycosides 3 C21-steroids have been isolated (in addition to the 2 known genins γ-digiprogenin and purpnigenin), and their structures elucidated. The presence of 2 sapogenins has been detected.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19670500516
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  • 9
    Electronic Resource
    Electronic Resource
    Die Glykoside der Blätter von Isoplexis canariensis (L.) G. DONFür diese Digitalis-Art sind früher andere botanische Bezeichnungen wie Isoplexis canariensis L. und Callianassa canariensis (W. & B.) verwendet worden. Die neue, heir benützte Nomenklatur haben wir aus der Arbeit von Werner [1] übernommen.. 2. Mitteilung1. Mitteilung: P. STUDER et al. [2]. (1967)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 50 (1967), S. 1893-1911 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Aus den getrockneten Blättern von Isoplexis canariensis liess sich nach leichter Abänderung des früher [2] beschriebenen Verfahrens in etwa 1% Ausbeute ein Kristallisat gewinnen, das aus den zwei Glykosidgemischen «A» und «B» im ungefähren Verhältnis 1:4 besteht. Diese unterscheiden sich nur im Zuckerteil - Canarobiose beim Glykosid «A» und Digilanidobiose beim Glykosid «B» - und besitzen die gleichen Aglykone: Uzarigenin, Canarigenin und Xysmalogenin. -2 der 3 Komponenten des Glykosids «A», nämlich Uzarigenin-glucosido-canarosid und Canarigenin-glucosido-canarosid, konnten als einheitliche Kristallisate gewonnen und in die Desglucoprodukte übergeführt werden. Das der 3. Komponente des Glykosids «A» entsprechende Desglucoprodukt, das Xysmalogenin-canarosid, liess sich aus dem Monosidgemisch «e» [2] (das aus «A» durch enzymatische Hydrolyse entsteht) gewinnen. -Das Glykosid «B» konnte bisher noch nicht in seine 3 Komponenten aufgeteilt werden. Aus seinem Monosidgemisch «d» wurden Uzarigenin-digitoxosid sowie Canarigenin-digitoxosid als einheitliche Glykoside und, nach saurer Hydrolyse, Xysmalogenin, das Aglykon des dritten Digitoxosids von «d», gewonnen. - Aus den Mutterlaugen der Glykosidgemische «A» und «B» konnten noch die Substanzen C und «D» erhalten werden. C ist Canarigenin-glucosido-fucosid, während «D» ein Gemisch mehrerer Glykoside darstellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19670500724
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  • 10
    Electronic Resource
    Electronic Resource
    Über neue Bufadienolide aus Ch'an Su. Über Krötengifte, 34. Mitteilung33. Mitt. [1], irrtümlicherweise als 32. Mitt. bezeichnet; 32. Mitt. = [2]. (1969)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 52 (1969), S. 1097-1101 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Two new bufadienolides, isolated from Ch'an Su, are proved to be 19-oxo-cinobufagin (III) and 19-oxo-cinobufotalin (V), respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19690520426
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