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  • 1965-1969  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 16 (1968), S. 328-332 
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Complete blood counts, bone marrow aspirations and autoradiographs of bone marrow smears were performed in twelve persons to whom Thorotrast (thorium dioxyde) had been given intravenously about 20 yars ago. Peripheral blood cell counts were within normal limits in all subjects; however, marrow smears of ten persons showed increased erythropoiesis. Furthermore an increase of binucleated red cell precursors which normally are rarely found, was noted. Thorotrast deposits were present in all marrow smears, and autoradiographs demonstrated many alpha-tracks radiating from the incorporated radio-active material. The question arises whether the cytologic abnormalities in the erythroblasts are due to the effect of continous exposure to low levels of ionising radiation.
    Notes: Zusammenfassung Bei 12 Personen, die vor ca. 20 Jahren Thorotrast erhalten hatten, wurden eine Blut- und Knochenmarkuntersuchung durchgeführt und von den Markausstrichen Autoradiographien angefertigt. Während das periphere Blutbild keine wesentlichen Abweichungen von der Norm zeigte, fand sich in 10 Fällen eine gesteigerte Erythropoese im Mark und in 8 Fällen das gehäufte Vorkommen von binukleären roten Vorstufen. Das Vorhandensein von Thorotrast im Knochenmark wurde autoradiographisch durch den Nachweis von α-Spuren im Bereich phagozytierender Retikulumzellen bestätigt. Es wird diskutiert, ob es sich bei den beobachteten mitoseabhängigen Zellatypien um Spätfolgen einer sogenannten “low level exposure” handeln könnte.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE DNA synthesis time of canine myelocytes has been reported to be about 7 h1. This estimate was used to calculate the relative rates of production of granulocytic precursors at different levels of maturation2'3. From these calculations, Patt et al.3 proposed that a "myelocyte sink" exists and ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cell & tissue research 83 (1967), S. 1-7 
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Die amitotische Kernteilung mit Cytoplasmadurchschnürung eines „Blasten“ aus der Phytohaemagglutinblutkultur mit nachfolgender Cytoconjunction zur zweikernigen Zelle und Degeneration wird beschrieben und mit Filmbildern belegt. Die Bedeutung des Vorgangs für die Zellregeneration der Haematopoese wird in Frage gestellt.
    Notes: Summary At the third day in the phytohaemagglutinin blood culture a blast undergoes an amitotic division of the nucleus with division of the cytoplasm within 20 seconds. 18 min later the two newly formed daughter cells produce a fusion of their cytoplasms and become a binucleated cell, later degenerating by lytical decay. The process is described in detail and kinematographically documented. The signification of the amitotic process for the regeneration of the haematopoiesis is uncertain.
    Type of Medium: Electronic Resource
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