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  • 1
    Electronic Resource
    Electronic Resource
    Studies on a diabetic (KK) strain of the mouse (1967)
    Springer
    Diabetologia 3 (1967), S. 212-221 
    Details
    ISSN: 1432-0428
    Keywords: Spontaneous Diabetes ; KK mice ; Japanese mice ; Obesity ; Growth hormone ; Pituitary ; Islets of Langerhans ; Pancreas ; Ultrastructure ; Beta cells ; Insulin in pancreas ; Sex and diabetes ; Adrenal cortex ; Zinc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé 1. Un état diabétique est démontré chez des souris d'une souche japonaise, la souche KK, mis en évidence par une élévation du sucre sanguin et par une diminution de la tolérance au glucose. 2. Le poids corporel des souris KK dépasse la normale; il s'agit d'une obésité modérée. 3. L'activité insulinique du pancréas et le contenu en hormone de croissance de l'hypophyse de souris KK dépassent ceux observés chez des souris C57BL. 4. Histologiquement, on trouve chez les souris KK une hypertrophie et une hyperplasie des îlots de Langerhans, une hypertrophie et une dégranulation des cellules B, une abondance de ribosomes et de réticulum endoplasmique des cellules B, un développement marqué de la région de Golgi des mêmes cellules, et une diminution du contenu en zinc des cellules insulaires. D'autres anomalies ont également été observées dans d'autres organes des souris KK, plus particulièrement pour l'hypophyse, le foie, les surrénales et la parathyroïde.
    Abstract: Zusammenfassung 1. Bei Mäusen des KK-Stammes (japanische Zucht) ist mit Bestimmung von Glucosetoleranz und Blutzuckerwerten ein diabetischer Zustand nachweisbar. 2. Das Körpergewicht von KK-Mäusen liegt über der Norm, und es besteht eine leichte Fettsucht. 3. Die Insulinaktivität des Pankreas und der Gehalt der Hypophyse an Wachstumshormon sind bei KK-Mäusen höher als bei C57BL-Mäusen. 4. Das Pankreas der KK-Mäuse zeigt auffallende Veränderungen, wie Hypertrophie und Degranulierung derβ-Zellen, reichlich Ribosomen und endoplasmatisches Reticulum in denβ-Zellen, sowie starke Ausbildung des Golgiapparates und Verminderung des Zinkgehaltes der Inselzellen. 5. Auch andere Organe (z.B. Adenohypophyse, Leber, Nebenniere und Nebenschilddrüse) der KK-Mäuse weisen Veränderungen auf.
    Notes: Summary This review demonstrates the following points:1. By glucose tolerance test and the determination of non-fasting blood sugar values, mice of KK strain (a Japanese strain) have been shown to be in a diabetic state. 2. KK mice have greater than normal body weights, and moderate obesity. 3. Pancreatic insulin activity and adenohypophyseal growth hormone content of KK mice are greater than those of C75BL mice. 4. The pancreas of KK mice presents many striking changes, such as the hypertrophy and hyperplasia of the islets, the hypertrophy and degranulation of B cells, the abundance of B cell ribosomes and endoplasmic reticulum, the enlargement of the Golgi areas of B cells, and the diminution of the zinc content of insular cells. 5. In other organs (eg. adenohypophysis, liver, adrenal and parathyroid) of KK mice, many changes are also observed. The above features of KK mice are discussed in relation to the presumed metabolic disorder in the mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01222198
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  • 2
    Electronic Resource
    Electronic Resource
    Light and electron microscopic studies on the adenohypophysis of a diabetic (KK) strain of the mouse (1967)
    Springer
    Cell & tissue research 79 (1967), S. 429-445 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Light and electron microscopic observations have been made on the adenohypo-physeal tissues of male mice which belong to either KK or C57 BL/6 strain, and the following results were obtained. 1. The acidophil cells of KK mice show evidence of hypertrophy and hyperplasia as compared with those of C57 BL/6 animals. The cytoplasm of the cells exhibits an intense stainability with orange G. Electron microscopically α cells of KK mice show an abundance of secretory granules and the scarcity and irregular arrangement of endoplasmic reticulum. 2. The PAS-basophil cells seen in the interior of the gland occur less frequently in KK mice than in C57 BL/6 animals. 3. The FSH cells of KK mice contain a larger number of distinct granules and have a larger Golgi complex than those of C57 BL/6 mice. 4. In the both mouse strains examined, three types of agranular cells are distinguished in the pituitary gland. Of these three cell types, only one type shows a variation in frequency with different strains; namely, it appears occasionally in C57 BL/6 mice, while being rare in KK animals. 5. The present observations on the fine structures of the anterior pituitary cells in C57 BL/6 mice are almost coincident with Barnes' reports (1962, 1964) on the ultrastructure of the same gland. 6. Both the light and electron microscopic features of the anterior pituitary cells in KK mice were discussed in relation to the metabolic disorders which have been presumed from a series of our previous studies on several organs of the diabetic animals (Nakamura, 1965; Nakamura and Yamada jr., 1965; Yamada jr., 1965).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00335485
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  • 3
    Electronic Resource
    Electronic Resource
    Enzymorphological studies on the pancreatic islets of a diabetic (KK) strain of the mouse (1965)
    Springer
    Cell & tissue research 66 (1965), S. 396-404 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The pancreatic islets of diabetic (KK) and control (C57 BL/6) strains of the mouse have been studied by histochemical methods for the demonstration of a series of hydrolyzing enzymes, and the following results were obtained. 1. In KK mice alkaline phosphatase activity is demonstrated in fewer insular cells and more vascular walls than in control animals. 2. The islet cells of older KK mice exhibiting persistent glucosuria react for acid phosphatase less intensely than those of control animals. 3. In the islet cells of KK animals glucose-6-phosphatase activity is significantly higher than that revealed by the cells of control mice. 4. The islet cells of both the KK and control mice exhibit moderate ATP-ase activity, and there is no strain difference in the morphological features of the enzyme activity. 5. All the present enzymorphological data were discussed with special reference to the presumed metabolic disturbance in the diabetic (KK) mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334721
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  • 4
    Electronic Resource
    Electronic Resource
    Cytological and histological studies on the pancreatic islets of a diabetic strain of the mouse (1965)
    Springer
    Cell & tissue research 65 (1965), S. 340-349 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cytological and histological observations have been made on the pancreatic islets of a diabetic (KK) strain of the mouse, and of control mice which belong to either C57BL/6 or ddN strains, and the following results were obtained. 1. In the pancreas of the diabetic mouse strain a certain number of irregularly contoured islets and occasional insular hypertrophy and hyperplasia are observed in contrast to the insular tissues of control animals. 2. The insular B cells of KK animals are seen to undergo cellular hypertrophy. The intracellular granules of this cell type are smaller in amount, colored darker and more coarse in size in KK individuals than in control animals. 3. In some insular tissues of KK mice there occur frequently varying degrees of sinusoidal dilatation of blood capillaries. 4. The cytoplasm of the insular A cells in KK animals is of a fine granulation which tends to be colored in a significantly less intense rose pink shade than that in control individuals. 5. The average proportion of the insulare A cells in KK mice is assumed to be strikingly small. 6. The dithizone reaction of the cytoplasm of the insular B cells in KK animals denotes the scarcity of the cellular zinc content. 7. The present morphological data on the pancreatic islets of the diabetic mouse strain have been discussed in relation to growth hormone secretion of the anterior pituitary of the animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00345635
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