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  • Immunoscintigraphy  (2)
  • Polymer and Materials Science  (2)
  • (Ehrlich ascites cell membrane)  (1)
  • Analytical Chemistry and Spectroscopy  (1)
Source
Material
Years
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Calcium permeability of Ehrlich ascites tumour cell plasma membrane in vivo
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 686 (1982), S. 27-35 
    Details
    ISSN: 0005-2736
    Keywords: (Ehrlich ascites cell membrane) ; Ca^2^+ permeability ; Energy depletion ; Ionophore ; Mitotic activity
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2736(82)90148-1
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Imaging rheumatoid arthritis joints with technetium-99m labelled specific anti-CD4− and non-specific monoclonal antibodies (1994)
    Springer
    European journal of nuclear medicine 21 (1994), S. 176-180 
    Details
    ISSN: 1619-7089
    Keywords: Anti-CD4 monoclonal antibody ; Anti-carcinoembryonic antigen monoclonal antibody ; Immunoscintigraphy ; Technetium-99m labelling ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A direct comparison of the joint-imaging properties of inflammation-specific- and non-specific monoclonal antibodies (Mabs) was possible in a patient suffering from long-standing, severe rheumatoid arthritis (RA). This patient received an anti-CD4− and an anti-carcinoembryonic antigen (anti-CEA) Mab, both labelled with technetium-99m, 9 days apart from each other. The anti-CD4 Mab was superior to the isotype-matched anti-CEA Mab in imaging inflamed joints. In the knee joint, the target-to-background ratio of the synovial membrane (SM) activity in comparison to that of adjacent large vessels was 1.22 (SM/muscle 1.55) for the anti-CD4 Mab and 0.53 (SM/muscle 0.92) for the anti-CEA Mab, in both cases 4 h after injection of the immunoglobulin. Since the CD4 antigen is present on the surface of T-helper lymphocytes and macrophages infiltrating the inflamed synovial membrane, imaging with the anti-CD4 Mab may allow more specific detection of inflammatory infiltrates in RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00175768
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Imaging rheumatoid arthritis specifically with technetium 99m CD4-specific (T-helper lymphocytes) antibodies (1990)
    Springer
    European journal of nuclear medicine 17 (1990), S. 156-159 
    Details
    ISSN: 1619-7089
    Keywords: Immunoscintigraphy ; Technetium 99m-labelled antibodies ; CD4-specific (T-lymphocyte) antibodies ; Rheumatoid arthritis ; Localisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract CD4 expressing T-lymphocytes are involved in the pathogenesis of rheumatoid arthritis, so the possibility of using radiolabelled CD4-specific antibodies to localise diseased joints was studied. Prospectively six patients with rheumatoid arthritis were investigated. Five of them received 200–300 μg of a 555 MBq technetium 99m CD4-specific antibody (MAX.16H5) and were examined with three phase bone scans. Max.16H5 (IgG1) was labelled according to the mercaptoethanol (Schwarz) method. Lymphocytes of one patient were isolated on a Ficoll-Hypaque gradient and labelled with the antibody in vitro. Scans were performed 1.5 h, 4 and 24 h post injection in anterior and posterior views. In all patients, diseased joints could be clearly imaged at as early as 1.5 h. The localisation of the diseased joints correlated (P〈0.01) with the clinical signs, with the early methylene diphosphonate (MDP) scan (P 〉 0.01) and only weakly with the late bone scan (P 〉 0.05). According to these data we conclude that99mTc-labelled CD4-specific antibodies specifically image actively diseased joints in rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00811445
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Source of the carboxamide nitrogen atom in 2-carboxamido-5-isopropoxycarbonylaminobenzimidazole, a metabolite of cambendazole (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 190-191 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Combined gas chromatography-mass spectrometry and isotope labeling techniques have been employed to demonstrate that the carboxamide nitrogen atom in 2-carboxamido-5-isopropoxycarbonylaminobenzimidazole, a metabolite of 2-thiazolyl-5-isopropoxycarbonylaminobenzimidazole (cambendazole), is derived wholly from the parent drug. [15N] Thiazole-labeled cambendazole was administered to a rat and the metabolite isolated from urine. Trideutero-2-carboxamido-5-isopropoxycarbonylaminobenzimidazole was employed as a carrier to isolate the metabolite in sufficient purity for isotope ratio measurements using multiple ion detection. The metabolite was converted to its tetramethyl derivative by on-column reaction with trimethylanilium hydroxide to permit satisfactory gas chromatography.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010308
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  • 5
    Electronic Resource
    Electronic Resource
    Dehydrocyclisierung von n-Hexan an bimetallischen Platin-Katalysatoren auf der Basis säurebehandelter Kieselgele (1978)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 50 (1978), S. 956-957 
    Details
    ISSN: 0009-286X
    Keywords: Heterogene Katalyse ; Platin-Trägerkatalysatoren ; Bimetall-Katalysatoren ; Dispersität ; Aromatisierung ; Hydrogenolyse ; Aromatisierung ; n-Hexan ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330501214
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Permeationsuntersuchungen an stabilisierten Schaumlamellen (1979)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 30 (1979), S. 426-431 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: The time-dependence of the permeation of methanol vapour through tenside-alginate foam lamels was determined by measuring the permeation, diffusion and solubility coefficients. Steady-state transport was found to occur only within narrow time limits. The agreement of calculated and experimental relationships between the coefficients suggest solution diffusion as proposed by BARRER. The transport mechanism can be explained by the place exchange theory and by the cluster theory according to LUCK.
    Notes: Für Tensid/Alginat-Schaumlamellen wurde der Durchtritt von Methanoldampf an Hand der Permeations-, Diffusions-und Löslichkeitskoeffizienten in Abhängigkeit von der Zeit ermittelt. Stationäre Transportzustände existieren nur in engen Zeitintervallen. Aus der Übereinstimmung zwischen den berechneten und experimentell ermittelten Koeffizienten-Beziehungen wird auf eine Lösungsdiffusion nach BARRER geschlossen. Der Transportmechanismus kann auf der Grundlage der Platzwechseltheorie sowie der Cluster-Theorie nach LUCK gedeutet wurden.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1979.010300710
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