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  • Polymer and Materials Science  (14)
  • (Human)  (2)
  • Cytochrome P450  (2)
  • Emulsions and suspensions  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Hb F-Forest Park, a new ^Aγ variant with two amino acid substitutions, 75(E19)Ile -〉 Thr and 73(E17)Asp -〉 Asn, which can be identified in adults by gene-mapping analysis
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular 832 (1985), S. 242-247 
    Details
    ISSN: 0167-4838
    Keywords: (Human) ; Amino acid substitution ; Gene mapping ; Hemoglobin variant ; Reverse-phase HPLC
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4838(85)90256-0
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  • 2
    Electronic Resource
    Electronic Resource
    Induction of aromatase gene expression in human placental choriocarcinoma (JAR) cells by phorbol esters
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Gene Structure and Expression 1218 (1994), S. 48-54 
    Details
    ISSN: 0167-4781
    Keywords: (Human) ; Aromatase ; Aromatase expression ; Phorbol ester
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4781(94)90099-X
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of caloric restriction on rodent drug and carcinogen metabolizing enzymes: implications for mutagenesis and cancer
    Amsterdam : Elsevier
    Mutation Research DNAging 295 (1993), S. 201-222 
    Details
    ISSN: 0921-8734
    Keywords: Caloric restriction ; Cytochrome P450 ; Drug metabolism
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-8734(93)90021-T
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Small-angle light scattering in dense microemulsions, transition from droplet to bicontinuous phase (1994)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 16 (1994), S. 1627-1633 
    Details
    ISSN: 0392-6737
    Keywords: Brillouin and Rayleigh scattering ; Liquids ; Emulsions and suspensions ; Order-disorder and statistical mechanics of model systems ; Conference proceedings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Summary We have performed extensive small-angle light scattering (SALS) measurements on a three-component microemulsion (AOT/decane/water) as a function of the dispersed phase concentration and the temperature. All samples have a water/AOT molar fractionw=40.8. Such a system presents a very complex phase diagram with many structural configurations. With the SALS technique, we have been able to observe all the phase separation lines. In particular we give details on the system structure on the percolation phenomenon and on the bicontinuous phase recently observed. In particular we show that the percolation is driven by a long-scale aggregation between microemulsion droplets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02462051
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  • 5
    Electronic Resource
    Electronic Resource
    Small-angle light scattering studies of dense AOT-water-decane microemulsions (1996)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 18 (1996), S. 1317-1332 
    Details
    ISSN: 0392-6737
    Keywords: Brillouin and Rayleigh scattering ; other light scattering ; Emulsions and suspensions ; Specific phase transitions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Summary We have performed extensive studies of a three-component microemulsion system composed of AOT-water-decane (AOT=sodium-bis-ethylhexyl-sulfosuccinate is an ionic surfactant) using small-angle light scattering (SALS). The small-angle scattering intensities are measured in the angular interval 0.001–0.1 radians, corresponding to a Bragg wave number range of 0.14 μm−1〈Q〈〈1.4 μm−1. The measurements were made by changing temperature and volume fraction ϕ of the dispersed phase (water + AOT) in the range 0.05〈ϕ〈0.75. All samples have a fixed water-to-AOT molar ratio,w=[water]/[AOT]=40.8, in order to keep the same average droplet size in the stable one-phase region. With the SALS technique, we have been able to observe all the phase boundaries of a very complex phase diagram with a percolation line and many structural organizations within it. We observe at the percolation transition threshold, a scaling behavior of the intensity data. This behavior is a consequence of a clustering among microemulsion droplets near the percolation threshold. In addition, we describe in detail a structural transition from a droplet microemulsion to a bicontinuous one as suggested by a recent small-angle neutron scattering experiment. The loci of this transition are located several degrees above the percolation temperatures and are coincident with the maxima previously observed in shear viscosity. From the data analysis, we show that both the percolation phenomenon and this novel structural transition are derived from a large-scale aggregation between microemulsion droplets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02453266
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  • 6
    Electronic Resource
    Electronic Resource
    Induction and suppression of renal and hepatic cytochrome P450-dependent monooxygenases by acute and chronic streptozotocin diabetes in hamsters (1996)
    Springer
    Archives of toxicology 70 (1996), S. 202-208 
    Details
    ISSN: 1432-0738
    Keywords: Key words Diabetes ; Cytochrome P450 ; Monooxygenase ; Hamster ; Streptozotocin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The acute and chronic effects of streptozotocin diabetes on kidney and liver microsomal monooxygenases were studied using hamsters 2 days and 6 weeks following treatment with the diabetogen, respectively. Acute diabetes increased aniline hydroxylation and N-nitrosodimethylamine demethylation, decreased pentoxyresorufin O-dealkylation, without affecting benzo(a)pyrene hydroxylation and 7-ethoxycoumarin O-deethylation in kidney and liver microsomes. The effects of chronic diabetes on the microsomal monooxygenases were similar to the effects of acute diabetes, except that the chronic diabetic condition markedly decreased benzo(a)pyrene and 7-ethoxycoumarin oxidations in kidney microsomes. Total cytochrome P450 content and NADPH-cytochrome P450 reductase activity in kidney and liver microsomes of the diabetic hamsters were similar to the controls. Gel electrophoresis of microsomes from control and streptozoptocin treated hamster tissues revealed that diabetes enhanced the intensity of protein band(s) in the P450 molecular weight region. Immunoblotting of microsomal proteins showed that acute and chronic streptozotocin diabetes induced proteins immunorelated to P450s 2E1 and 1A in kidney and liver. In marked contrast, the acute and chronic diabetic conditions decreased the level of a P450 2B-immunorelated protein(s) in kidney and liver. The present study demonstrates that acute and chronic streptozotocin diabetes has the ability to induce P450 2E1 and 1A and suppress P450 2B in hamster kidney and liver and that the hamster monooxygenase responds to diabetes differently from the rat enzyme.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002040050261
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  • 7
    Electronic Resource
    Electronic Resource
    Analysis and experimental study of gas penetration in a gas-assisted injection-molded spiral tube (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 58 (1995), S. 793-799 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Characteristics of gas penetration and polymer melt flow in gas-assisted injection molded spiral tubes was investigated by simulations and experiments. Distribution of the skin melt thickness along the gas flow direction was measured, and gas penetration in the primary and secondary stages was identified. An algorithm based on the control-volume/tiniteelement method combined with a particle-tracing scheme using a dual-filling-parameter technique is utilized to predict the advancements of both melt front and gas from during the molding process. The simulated distribution of gas penetration shows reasonably good coincidence with experimental observations. © 1995 John Wiley & Sons, Inc.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1995.070580412
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  • 8
    Electronic Resource
    Electronic Resource
    Morphology and mechanical properties of injection-molded specimens of two-phase polymer blends (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 21 (1977), S. 353-370 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: An experimental study was carried out to investigate the moldability of polymer blends which form two phases in the molten state and the effect of mixing on the morphology and mechanical porperties of molded specimens. Blends of polystyrene with polypropylene and blends of polystyrene with high-density polyethylene were used for this study. A plunger-type injection molding machine (Van Dorn) was employed for molding specimens. To improve the mixing performance of the plunger machine, a Static Mixer (Kenics Corp., Super Nozzle) was installed between the heating cylinder and the sprue. A number of different molding conditions (injection pressure, temperature, injection time, cooling time) were varied, and molded specimens were collected under each molding condition. The specimens were used for studying the degree of dispersion in the blends and for determining the mechanical properties. A differential thermal analysis (DTA) experiment was also carried out to determine the degree of dispersion of the blends in molded specimens. It was found that a linear correlation exists between the blend composition and thermal spectra area of the blends tested.
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1977.070210205
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  • 9
    Electronic Resource
    Electronic Resource
    The effect of mixing on the modes of dispersion and rheological properties of two-phase polymer blends in extrusion (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 19 (1975), S. 2831-2843 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: An experimental study was carried out to investigate the effect of mixing on the state of dispersion and rheological properties in the two-phase flow of polymer blends. For the study, blends of polystyrene and polypropylene were used, and two mixing devices were employed: a single-screw extruder combined with a “static mixer,” and a twin-screw compounding machine. Materials of various blending ratios were extruded at a constant temperature (200°C) through a capillary die having an L/D ratio of 20 (D = 0.125 in.). The state of dispersion in the two-phase system was investigated from pictures taken of the microstructure of the extrudate samples. It was found that different mixing devices have a profound influence on the state of dispersion of one polymer in another. Also determined were the rheological properties of the two-phase system investigated, from wall normal stress measurements. Our results show that, when shear stress is used as a parameter, the melt viscosity goes through a minimum, whereas the melt elasticity goes through a maximum. This is regardless of the type of mixing device employed, although the shapes of the curves are affected by the type employed. It is suggested that shear stress, instead of shear rate, be used in correlating the viscoelastic properties of two-phase polymer systems.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1975.070191019
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  • 10
    Electronic Resource
    Electronic Resource
    Diffusion and solubility of some azo dyes in swollen gelatin matrices: The effects of dye size, matrix swell, and dye-matrix interactions (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 30 (1985), S. 2075-2094 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The diffusion coefficient (D) and the solubility coefficient (K) of three sulfonated azo dyes were measured in swollen gelatin membranes at pH 12 by two techniques (time lag and desorption rate), with good agreement between the two. A strong correlation was established between log D and the reciprocal of the free volume of the matrix. Hence, as free volume of the matrix increased (due to increasing solvent imbibition), dye mobility increased. As dye size increased, however, mobility decreased. Dye affinity for gelatin, as measured in dilute solutions by dynamic dialysis, was small and could be related to the dye solubility in more concentrated gelatin matrices. Increasing ionic strength or decreasing alcohol content increased K without affecting the dye mobility. On the other hand, the presence of polymers with strong affinity for the dye anions, e.g., polyvinylpyrrolidone, immobilized a large fraction of the dye ions and greatly slowed the overall dye transport.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1985.070300524
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