ISSN:
1437-160X
Keywords:
Plasminogen activation
;
Plasmin
;
α2-Plasmin inhibitor
;
Complements
;
Systemic lupus erythematosus
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We measured α2-plasmin inhibitor-plasmin complexes (PI-PC) in plasma of patients with systemic lupus erythematosus (SLE) to examine the plasminogen activation in SLE. The plasma PI-PC level in 23 patients with SLE was significantly higher than that in 18 normal subjects (P〈0.001) and the SLE patients with nephrotic syndrome had higher plasma PI-PC levels than those without nephrotic syndrome (P〈0.01). In addition, the plasma PI-PC level was significantly correlated with the level of plasma C3 breakdown products (iC3b/C3dg) in the patients with SLE (r=0.53, P〈0.01). These results suggest that plasminogen is activated in plasma of patients with SLE and that the plasminogen activation may be associated with the activation of complement in SLE.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00270984
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