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  • *DNA-fingerprinting  (1)
  • Cerebral Blood Flow  (1)
  • brain metabolism  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Cerebral glucose and energy metabolism, cerebral oxygen consumption, and blood flow in arterial hypoxaemia (1978)
    Springer
    Acta neurochirurgica 44 (1978), S. 151-160 
    Details
    ISSN: 0942-0940
    Keywords: Hypoxia ; brain metabolism ; cerebral blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of moderately reduced arterial oxygen tension (aPO2 of about 45 Torr) on the metabolism and the blood flow of the brain was tested in 20 anaesthetized, artificially ventilated normotensive, normocapnic beagle dogs. It is demonstrated that the decrease in systemic oxygen delivery to the brain is countered by an appropriate increase in flow (CBF being 60.3 ml/100 g min at normoxia and 84.5 mg/100 g min m hypoxaemia) which maintained the cerebral oxygen consumption unchanged (CMRO2 3.80 versus 3.32 ml/100 g min). The cortical tissue content of energy-rich phosphates such as ATP, ADP, AMP, and phosphocreatine was also found to be unaltered. Neuropathological examinations excluded any hypoxic cell damage. This reactive vasodilatory reaction of the cerebral vessels is apparently a sensitive regulatory process which protects the brain against marked oxygen lack. However, a normal carbohydrate metabolism is not restored by this cerebrovascular mechanism. For, significantly increased CMRlactate (0.32 versus 1.46 ml/100 g min) indicated raised cerebral glycolysis, and the tissue metabolites of glucose suggested an increased glycolytic flux in the brain. It is concluded that in moderate arterial hypoxaemia, which is not uncommon in clinical practice, cerebral blood flow plays an effective homeostatic role in preventing a disturbance of the energy metabolism of the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402057
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Rearrangements at a DNA-fingerprint locus in the rice blast fungus (1996)
    Springer
    Current genetics 30 (1996), S. 263-271 
    Details
    ISSN: 1432-0983
    Keywords: Key wordsMagnaporthe ; Rice blast ; *DNA-fingerprinting ; Retrotransposon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Populations of the rice blast fungus, Magnaporthe grisea, can be sorted into clonal lineages based on restriction fragment length polymorphisms (RFLPs) detected with the repetitive DNA sequence MGR586. Mechanisms that produce DNA-fingerprint variation among lineages, are not known. In the process of analyzing the meiotic segregation of MGR586 RFLPs we identified a novel polymorphism, called MGR586-P2, in one member of a sister-spore pair from a complete tetrad. Molecular cloning revealed that P2 was generated by a nearby insertion of a novel, long-terminal-repeat (LTR)-containing retrotransposon. Genetic analysis showed that P2 and its progenitor polymorphism (P1) are alleles of a single polymorphic locus termed MGR586-PL (PL). Surprisingly, we found that a strain harboring PL recurrently produced clonal descendants harboring P1, P2 and possibly a third allele designated P3. PL is not located near a telomeric region. Our results show that some DNA-fingerprint loci may be hypervariable and undergo recurrent rearrangements. These findings have implications for interpreting DNA-fingerprint profiles from M. grisea populations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002940050131
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of stepwise arterial hypotension on blood flow and oxidative metabolism of the brain (1974)
    Springer
    Pflügers Archiv 351 (1974), S. 161-172 
    Details
    ISSN: 1432-2013
    Keywords: Arterial Hypotension ; Cerebral Blood Flow ; Oxidative Metabolism ; Non-hypoxic Lactacidosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary With the Kety-Schmidt-technique in ten dogs anaesthetized with 0.5% halothane, blood flow and oxidative metabolism of the brain were studied during stepwise lowering of CPP due to arterial hypotension at 71 and 41 torr. CBF remained constant (65.6 and 64.1 ml/100 g min) when CPP dropped from 98 to 71 torr, but at a CPP of 41 torr CBF fell to 32.2 ml/100 g min, i. e. to about 50% of the resting value. The CMR-oxygen did not change (4.20 and 4.38 ml/100 g min) when CPP was reduced from about 100 to about 70 torr, but decreased to 2.90 ml/100 g min, i. e. about 70% of the resting value in deep arterial hypotension. The uptake of glucose changed from 4.62 to 6.19 mg/100 g min as well as the output of CO2 and lactate (from 4.64 to 6.57 ml/100 g min and from 0.33 to 1.62 mg/100 g min) when CPP was decreased to 71 torr. It could be demonstrated that at this CPP range the oxidative metabolism was unchanged. It was assumed that the increased uptake of glucose was only to form lactate, and that this non-hypoxic lactate production was responsible for the elevated CO2 release. At a CPP range of 41 torr the metabolic rates of glucose and CO2 decreased to 3.33 mg/100 g min and to 3.37 ml/100 g min, respectively, while the output of lactate remained relatively high (1.14 mg/100 g min). These findings support the assumption that at a CPP range of 41 torr the oxidative metabolism of the brain becomes insufficient. All findings demonstrate close interactions between cerebral flow blood and oxidative brain metabolism in arterial hypotension. In deep arterial hypotension respiratory acidosis has an effect on CBF. The increase of CBF is accompanied by an improvement of CMR-oxygen but not of CMR-glucose. Although CMR-lactate is reduced, the lactate/glucose index remains high.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587434
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    Paper (German National Licenses)
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