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  • 1
    Electronic Resource
    Electronic Resource
    25 Hydroxyvitamin D and vitamin E absorption in healthy children and children with chronic intrahepatic cholestasis (1989)
    Springer
    European journal of pediatrics 148 (1989), S. 605-609 
    Details
    ISSN: 1432-1076
    Keywords: 25-Hydroxyvitamin D ; 1,25-Dihydroxyvitamin D ; Vitamin E-Vitamin D binding protein ; Chronic cholestasis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patients with chronic cholestasis have reduced 25-hydroxyvitamin D (25 OHD) and vitamin E levels. We determined serum concentrations of 25 OHD, 1,25-dihydroxyvitamin D [1,25(OH)2D] and vitamin E before and after oral administration of 10 μg/kg body weight 25-hydroxyvitamin D3 (25 OHD3) and 100 IU/kg body weight vitamin E, respectively, in 4 patients with intrahepatic cholestasis and 6 healthy children. Vitamin E increased in all controls but in only one of the four patients. In contrast, oral 25 OHD3 induced a normal rise in circulating 25 OHD and 1,25(OH)2D. The low serum levels of 25 OHD in the patients before the oral bolus may have been due to inadequate parenteral vitamin D administration and/or to the simultaneous phenobarbital treatment. The latter possibility is supported by the increase of serum 25 OHD into the normal range after withdrawal of phenobarbital in one of the four patients. We conclude that vitamin E has to be supplemented parenterally or in water-soluble oral form. Further studies are necessary to clarify whether high-dose long-term oral 25 OHD3 supplementation is sufficient to prevent vitamin D deficiency in patients with chronic cholestasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441510
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  • 2
    Electronic Resource
    Electronic Resource
    Antiretikulin-Antikörper und präcipitierende Antikörper gegen Nahrungsmittelproteine im Serum von Kindern mit Cöliakie (1976)
    Springer
    European journal of pediatrics 121 (1976), S. 215-226 
    Details
    ISSN: 1432-1076
    Keywords: Coeliac disease ; Antireticulin antibodies ; Precipitating antibodies to wheat flour ; Precipitating antibodies to cow's milk
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Antiretikulin-Antikörper im Serum wurden mit der Methode der indirekten Immunfluorescenz an frischen Rattennierenschnitten bei 11/13 Kindern (85%) mit florider Cöliakie, 7/17 Kindern (41%) mit klinisch und biochemisch stummem, bioptisch nachgewiesenem Cöliakie-Rezidiv und 0/16 Kindern mit behandelter Cöliakie nachgewiesen. Präcipitierende Antikörper im Serum gegen Weizenmehl bzw. Kuhmilch wurden mit Hilfe einer Kombination aus Elektrophorese und Immundiffusion bei 3/13 Kindern (23%) bzw. 2/13 Kindern (15%) mit florider Cöliakie und bei 1/16 Kindern (6%) mit behandelter Cöliakie gefunden. Bei den 17 Kindern mit stummem Cöliakie-Rezidiv fiel die Untersuchung auf präcipitierende Antikörper negativ aus. 40 Kontrollkinder wiesen weder Antiretikulin-Antikörper noch präcipitierende Antikörper gegen Weizenmehl oder Kuhmilch auf. Die Bedeutung des Antiretikulin-Antikörper-Nachweises für Screening-Untersuchungen und für die Verlaufskontrolle wird diskutiert.
    Notes: Summary Sera from 41 children suffering with histologically proven coeliac disease and from 40 healthy control children were investigated for the presence of antireticulin antibodies and precipitating antibodies to a watery extract of wheat flour and to cow's milk. Antireticulin antibodies were demonstrated by means of indirect immunofluorescence using sections of fresh rat kidney as substrat. For the detection of precipitating antibodies a combination of electrophoresis and immunodiffusion was used. Serum antireticulin antibodies were found in 11/13 children (85%) with active coeliac disease, in 7/17 children (41%) with clinically and biochemically silent coeliac relapse and in 0/16 children with treated coeliac disease. Serum precipitating antibodies to wheat flour and cow's milk were found respectively in 3/13 children (23%) and 2/13 children (15%) with active coeliac disease and in 1/16 children (6%) with treated coeliac disease. Precipitating antibodies could not be detected in the sera of 17 patients with silent relapse of coeliac disease. In the sera of 40 controls neither antireticulin nor precipitating antibodies were detectable. The presence of antireticulin antibodies in serum did not correspond to the presence of serum precipitins to wheat flour and cow's milk. The significance of serum antireticulin antibodies for sereening investigations and for follow-up studies is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445484
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  • 3
    Electronic Resource
    Electronic Resource
    Vitamin A, Carotin, retinolbindendes Protein und Präalbumin im Serum von Patienten mit cystischer Fibrose (1975)
    Springer
    European journal of pediatrics 119 (1975), S. 279-291 
    Details
    ISSN: 1432-1076
    Keywords: Vitamin A ; Carotene ; Retinol-binding protein ; Prealbumin ; Cystic fibrosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 42 Patienten mit cystischer Fibrose (CF) und bei 92 Normalpersonen wurden die Serumkonzentrationen von Vitamin A, Carotin, retinolbindendem Protein (RBP) und Präalbumin (PA) bestimmt. Alle Patienten mit CF erhielten Vitamin A-Palmitat in Form eines Multivitaminpräparates in der doppelten empfohlenen Dosis für Gesunde. Bei der statistischen Prüfung waren die Serumkonzentrationen von Vitamin A, Carotin und RBP bei den Patienten mit CF im Vergleich zu den Normalpersonen erniedrigt (P〈0,001). Für das PA ließ sich zwischen beiden Gruppen ein statistisch signifikanter Unterschied nicht sichern. Bei den Normalpersonen fand sich nur für das PA ein altersabhängiger Anstieg (r=0,455, P〈0,001). Bei den Patienten mit CF nahmen die Serumkonzentrationen von Vitamin A in Korrelation zum Lebensalter ab (r=−0,423, P〈0,01). PA und RBP sowie RBP und Vitamin A waren bei beiden Gruppen signifikant gleichsinnig korreliert (P〈0,001). Bei den Normalpersonen ergab sich auch zwischen Vitamin A und Carotin eine positive Korrelation (r s=0,606, P〈0.001), während bei den Patienten mit CF diese Beziehung schwächer signifikant war (r s=0,311, P〈0,02).
    Notes: Abstract Vitamin A, carotene, retinol-binding protein (RBP), and prealbumin (PA) have been measured in 42 children and adolescents with cystic fibrosis (CF) and in 92 normal controls. All patients with CF were on vitamin A palmitate in twice the dose for normals. For statistical analysis U-test of Wilcoxon, Mann and Whitney, parametric correlation coefficient and Spearman's rank correlation coefficient were used. Compared with those in normal controls mean serum concentrations of vitamin A, carotene and RBP were depressed in patients with CF (P〈0.001), whereas PA levels did not differ significantly from those of normal individuals. In normal controls there was only in serum concentration of PA an elevation with age (r=0.455, P〈0.001). In patients with CF, serum concentration of vitamin A decreased in correlation with age (r=−0.423,P〈0.01). PA and RBP as well as RBP and vitamin A were positively related in both groups (P〈0.001). In normal individuals there was a highly significant correlation between serum concentrations of vitamin A and carotene (r s=0.606, P〈0.001), whereas in patients with CF this relationship was less significant (r s=0.311, P〈0.02).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443512
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