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  • Botulinum toxin  (2)
  • Parkinson's disease  (2)
  • 12-methoxyabietic acid  (1)
  • 1
    Electronic Resource
    Electronic Resource
    3H-spiperone binding to lymphocytes fails in the differential diagnosis of de novo Parkinson syndromes (1993)
    Springer
    Journal of neural transmission 5 (1993), S. 107-116 
    Details
    ISSN: 1435-1463
    Keywords: Spiperone binding ; Parkinson's disease ; multiple system atrophy ; vascular lesions ; differential diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to investigate the diagnostic value of3H-spiperone binding capacity to lymphocytes in the differential diagnosis of de novo Parkinson's disease (idiopathic Parkinson syndrome, PD), we performed a double blind prospective study of spiperone binding capacity of 123 patients and 23 healthy control persons, belonging to different diagnostic groups (PD, Parkinsonian syndrome due to vascular lesions, multiple system atrophy [MSA], essential tremor). Diagnoses were based on medical history, clinical examination, CT or MRI scan, acute response to dopamimetric drugs, one year follow up, and long term response to L-DOPA treatment. Spiperone binding was assayed using ten different concentrations (0.03–3 nmol) in absence or presence of 1μmol (+)-butaclamol to determine nonsepecific binding. There was no significant difference in spiperone binding between patients with PD not treated with L-DOPA, and patients with other basal ganglia disorders including parkinsonian syndrome due to vascular lesions, multiple system atrophy, or progressive supranuclear palsy, and age matched controls. Binding was significantly higher in parkinsonian patients with PD treated with L-DOPA and patients with essential tremor. It is concluded that at present3H-spiperone binding gives no further information in the differential diagnosis of de novo Parkinson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02251201
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Clinical and polymyographic investigation of spasmodic torticollis (1992)
    Springer
    Journal of neurology 239 (1992), S. 9-15 
    Details
    ISSN: 1432-1459
    Keywords: Spasmodic torticollis ; Botulinum toxin ; Polymyography ; Pathophysiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Polymyographic recordings were used to identify the most dystonic muscles suitable for local injection with botulinum toxin in 100 patients with spasmodic torticollis (TS). Rotating TS (72% of the patients) was due to dystonic activity of the splenius muscle ipsilateral to and/or the sternocleidomastoid muscle contralateral to the side of chin deviation. One-third of these patients had also dystonic activation of the contralateral splenius muscle and, rarely, the contralateral trapezius muscle. Ten patients had laterocollis due to dystonic activation of all recorded muscles on one side of the neck. Nine patients had retrocollis due to activity of both splenius muscles and rarely additional activity in both trapezius muscles. The type of dystonic muscle activity was found to be tonic, phasic or tremulous. Besides the evaluation of spontaneous dystonic EMG activity further examination during the “geste antagoniste” or the muscle activity during rotating head movements can provide additional information. It is concluded that polymyography may provide a rationale for identifying the dystonic muscles underlying the different forms of TS. It may prove to be helpful for the successful therapy with botulinum toxin and may be useful in differentiating tremulous torticollis from other types of head tremor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00839204
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Treatment of spasmodic torticollis with local injections of botulinum toxin (1992)
    Springer
    Journal of neurology 239 (1992), S. 21-25 
    Details
    ISSN: 1432-1459
    Keywords: Spasmodic torticollis ; Botulinum toxin ; Poly-EMG
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty-seven patients with spasmodic torticollis (cervical dystonia) who received repeated local injections of botulinum toxin have been followed up for a mean period of 12.3 (10–29) months, during which time 138 treatment sessions were performed. Mean doses per muscle averaged 320 mouse units (mu; range 160–1000 mu botulinum toxin A prepared by CAMR, Porton Down, UK). Eighty-six per cent of patients experienced significant improvement of posture and 84% of those with pain had relief following the first injection. Muscular patterns of recurrent torticollis were relatively constant and in most patients efficacy was maintained with subsequent injections, while 15% of all follow-up sessions failed. Only 2 of 37 patients were consistent non-responders; 22% and 10% of all sessions were complicated by transient dysphagia and weakness of neck muscles, respectively. It is concluded that local botulinum toxin injections can be a safe and efficaceous long-term treatment of spasmodic torticollis and that optimal doses should be between 200 and 400 mu/muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00839206
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Chemical basis of differential feeding behavior of the larch sawfly,Pristiphora erichsonii (Hartig) (1981)
    Springer
    Journal of chemical ecology 7 (1981), S. 599-614 
    Details
    ISSN: 1573-1561
    Keywords: Larch ; tamarack ; larch sawfly ; Pristiphora erichsonii ; abietic acid ; dehydroabietic acid ; 12-methoxyabietic acid ; sandaracopimaric acid ; isopimaric acid ; Larix laricina
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The machanisms by which the larvae of the larch sawfly,Pristiphora erichsonii (Hartig), are prevented from feeding on the single needles of the new shoot of tamarack,Larix laricina (DuRoi) K. Koch, were studied. As a result of extensive purification attempts, five deterrent chemicals were isolated and identified. They are: abietic, dehydroabietic, 12-methoxyabietic, sandaracopimaric, and isopimaric acid. These chemicals, particularly the first two, are abundant in mid-July to August in the single needles and, apparently, provide the basis for the deterrency against the larval feeding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00987708
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of age and disease duration on parkinsonian motor scores under levodopa therapy (1995)
    Springer
    Journal of neural transmission 9 (1995), S. 177-188 
    Details
    ISSN: 1435-1463
    Keywords: Parkinson's disease ; motor scores ; age ; disease duration ; levodopa
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary One hundred and fifty patients suffering from Parkinson's disease were analysed for the expression of the motor symptoms during optimum response to levodopa therapy (subscale III of the Unified Parkinson's Disease Rating Scale). Patients were grouped according to age (≤64, 65–74, ≥75 years). Disease duration and daily levodopa dosage were similar in the three groups. Pooled residual scores for posture and gait impairment (PGI), tremor (T), rigidity (R) and distal motor impairment (DMI; hand and foot movements) increased with age (Kruskal-Wallis ANOVA). The parkinsonian scores were significantly higher than the scores of 150 age-matched normal controls (Mann-Whitney U test). The differences between the patients' scores and the scores of the age-matched controls increased with age. In spite of a significant increase in the daily levodopa dosage with disease duration (linear regression), PGI aggravated age-dependently, and DMI age-independently with symptom duration (Spearman rank correlation). In contrast, T and R did not increase with disease duration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02259659
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    Paper (German National Licenses)
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