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  • 1
    Electronic Resource
    Electronic Resource
    Prolactin plasma levels and D2-dopamine receptor occupancy measured with IBZM-SPECT (1996)
    Springer
    Psychopharmacology 124 (1996), S. 285-287 
    Details
    ISSN: 1432-2072
    Keywords: 123Iodobenzamide ([123I]IBZM) ; Single photon emission computed tomography (SPECT) ; Dopamine-D2-receptor ; Prolactin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract By the application of123([123I]IBZM), an iodine-labelled dopamine D2-receptor antagonist, brain D2 receptors in humans can be visualized with single photon emission computed tomography (SPECT). The ratio of IBZM binding to striatal regions versus binding to frontal cortex (ST/FC ratio) provided a semiquantitative measurement of D2 receptor binding in the striatum. This study investigated the relationship between receptor occupancy and plasma prolactin levels in 12 male patients treated with haloperidol, benperidol or clozapine. Prolactin levels were positively correlated with D2 receptor occupancy, reflecting at least in part a comparable dopamine receptor antagonism in different dopaminergic pathways.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246671
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Decreased benzodiazepine receptor binding in panic disorder measured by IOMAZENIL-SPECT (1994)
    Springer
    European archives of psychiatry and clinical neuroscience 244 (1994), S. 49-51 
    Details
    ISSN: 1433-8491
    Keywords: Panic disorder ; Benzodiazepine receptor Iomazenil ; SPECT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Single photon emission tomography (SPECT) imaging of the central benzodiazepine receptor (BZr) became possible with the newly developed ligand123I-IOMAZENIL. The BZr binding was investigated in ten patients with panic disorder (PP) compared to ten epileptic patients (EP). Panic patients had lower IOMAZENIL uptake rates in the frontal, occipital and temporal cortex than EP, indicating the involvement of the BZr complex in panic disorder.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02279812
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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