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  • glucose  (2)
  • immunohisochemistry  (2)
  • 15N-Glycine  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Increased somatostatin secretion from pancreatic islets of streptozotocin-diabetic rats in response to glucose
    Amsterdam : Elsevier
    Molecular and Cellular Endocrinology 20 (1980), S. 243-250 
    Details
    ISSN: 0303-7207
    Schlagwort(e): diabetic rat islets ; glucagon ; glucose ; somatostatin secretion ; theophylline
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0303-7207(80)90040-4
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Specific detection of Helicobacter pylori and non–Helicobacter pylori flora in small- and large-cell primary gastric B-cell non-hodgkin's lymphoma (1997)
    Springer
    Annals of oncology 8 (1997), S. 33-36 
    Details
    ISSN: 1569-8041
    Schlagwort(e): bacterial flora ; Helicobacter pylori ; immunohisochemistry ; MALT ; primary gastric lymphoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Background: Primary gastric non-Hodgkin's lymphomas possibly develop in response to local infection by Helicobacter pylori (H. pylori). We investigated the presence of H. pylori and non–H. pylori flora histologically in small- and large-cell primary gastric lymphoma using a specific staining method. Materials and methods: Specimens of 52 cases of primary gastric lymphoma(17 small cell, 35 large cell) were stained with modified Giemsa (MG) and immunohistochemically using a polyclonal antibody against H. pylori (IHC). Results: Thirty-two cases (61.5%) (small cell 76% versus large cell 53%,P 〉 0.05) showed immunoreactivity for H. pylori in the mucosa surrounding the tumor. Remarkable, there waslocalization of H. pylori in the neck of the gastric glands in 3 cases.Non– H. pylori flora was seen in 35 cases (76.3%) (small cell53% versus large cell 74%,P 〉 0.05). In 20cases, this non– H. pylori flora was mixed with H. pylori. Five cases showed no bacterial flora at all. Conclusions: (1)Using immunohistochemistry, the prevalence of gastriclymphoma cases with H. pylori (61.5%) approximates that of H. pylori in the normal population. (2) No statistical difference was found between the occurrence of H. pylori and non–H. pyloribacterial flora in small- versus large-cell lymphoma. (3) Our results suggest that H. pylori may not be the only etiologic factor in primary gastric lymphoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008205510594
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Specific detection of Helicobacter pylori and non–Helicobacter pylori flora in small- and large-cell primary gastric B-cell non-hodgkin's lymphoma (1997)
    Springer
    Annals of oncology 8 (1997), S. 33-36 
    Details
    ISSN: 1569-8041
    Schlagwort(e): bacterial flora ; Helicobacter pylori ; immunohisochemistry ; MALT ; primary gastric lymphoma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Background: Primary gastric non-Hodgkin's lymphomas possibly develop inresponse to local infection by Helicobacter pylori (H. pylori). Weinvestigated the presence of H. pylori and non–H. pylori florahistologically in small- and large-cell primary gastric lymphoma using aspecific staining method. Materials and methods: Specimens of 52 cases of primary gastric lymphoma(17 small cell, 35 large cell) were stained with modified Giemsa (MG) andimmunohistochemically using a polyclonal antibody against H. pylori (IHC). Results: Thirty-two cases (61.5%) (small cell 76% versuslarge cell 53%,P 〉 0.05) showed immunoreactivityfor H. pylori in the mucosa surrounding the tumor. Remarkable, there waslocalization of H. pylori in the neck of the gastric glands in 3 cases.Non– H. pylori flora was seen in 35 cases (76.3%) (small cell53% versus large cell 74%,P 〉 0.05). In 20cases, this non– H. pylori flora was mixed with H. pylori. Five casesshowed no bacterial flora at all. Conclusions: (1)Using immunohistochemistry, the prevalence of gastriclymphoma cases with H. pylori (61.5%) approximates that of H. pylori in the normal population. (2) No statistical difference was foundbetween the occurrence of H. pylori and non–H. pyloribacterial flora in small- versus large-cell lymphoma. (3) Our resultssuggest that H. pylori may not be the only etiologic factor in primarygastric lymphoma.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008205510594
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Einbau von15N-Glyzin in VLDL und LDL: In-vivo-Synthese von Apolipoprotein B beim Menschen postabsorptiv und im Fastenzustand (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 280-285 
    Details
    ISSN: 1432-1440
    Schlagwort(e): 15N-Glycine ; Apolipoprotein-B-Synthesis ; Low density lipoprotein ; Very low density lipoprotein
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In vivo synthesis of apolipoprotein B 100 (ApoB) was recently determined in man using stable isotopes. With this procedure we analyzed (1) the effect of fasting on synthesis of ApoB from very low density lipoprotein (VLDL) and (2) tracer enrichment in low density lipoprotein (LDL). After a 36-hour fasting period and in the post-absorptive state 4 healthy subjects were given a priming dose (8.7 µmol/kg) of15N glycine followed by a constant infusion (10 µmol/kg/h for 8 h) to achieve 5% tracer enrichment in the plasma pool of glycine. The K-values, i.e. fractional synthetic rates/hr of ApoB from VLDL were 0.53±0.26 vs. 0.43±0.16 (p〉0.05). Tracer enrichment in ApoB from LDL at the end of the infusions was 0.19% vs. 1.46% in ApoB from VLDL. The results indicate that (1) in young healthy postabsorptive individuals about 40% of ApoB from VLDL in plasma is synthesized per hour, (2) fasting does not materially affect fractional ApoB synthesis and (3) at 5%15N enrichment in plasma glycine, tracer enrichment in ApoB from LDL is at the lower limit of detection for the procedure employed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01892895
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  • 5
    Digitale Medien
    Digitale Medien
    Permissive effect of glucose on the glucagon-induced accumulation of cAMP in isolated rat pancreatic islets (1977)
    Springer
    Diabetologia 13 (1977), S. 171-175 
    Details
    ISSN: 1432-0428
    Schlagwort(e): Isolated islets ; insulin release ; glucagon ; glucose ; cyclic adenosine monophosphate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Glucose stimulation increased the cAMP content of collagenase-isolated rat pancreatic islets fourfold above baseline values. The elevation was transient, lasting about 5 min, and was dose-dependent. Insulin release continued at a constant rate throughout the incubation. — Glucagon, in the absence of glucose, increased cAMP for about 1 min, but only slightly, and had no effect on insulin release. In the presence of glucose, however, glucagon enhanced islet cAMP content 15-fold and increased the release of insulin. Glucagon was most effective at high glucose concentrations (16.6 and 25 mM). — This indicates that glucagon is critically dependent on the presence of glucose in order to increase the islet cAMP content and to stimulate insulin release. The inability of glucagon to generate sufficient cAMP in the absence of glucose might be one of the reasons why the hormone is a potentiator rather than an initiator of insulin release.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00745146
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