ISSN:
0947-6539
Keywords:
carbohydrates
;
glycoproteins
;
HIV oligosaccharides
;
protecting groups
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The high-mannose nonasaccharide 1 is part of the glycoprotein gp 120 of the viral coat of HIV-1. The mannan portion of this triantennary glycan was prepared by a number of consecutive glycosidation steps without the need for any protecting-group manipulation. This was achieved by carefully tuning the reactivity of the glycosyl donors by employing our cyclohexane-1,2-diacetal (CDA) methodology. The method was further extended with one-pot procedures for oligosaccharide synthesis, thus reducing the number of steps to form the protected nonasaccharide 21 from the monosaccharide building blocks to five.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/chem.19970030315
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