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  • Gliosis  (2)
  • 25.70.−z  (1)
  • 27.60.+j  (1)
  • Antibody persistence  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Periodic acid-Schiff(PAS)-positive deposits in brain following kainic acid-induced seizures: relationships to fos induction, neuronal necrosis, reactive gliosis, and blood-brain barrier breakdown (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 126-138 
    Details
    ISSN: 1432-0533
    Keywords: Key words Neurodegeneration ; Epilepsy ; Kainic acid ; fos ; Gliosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Periodic acid-Schiff (PAS)-positive deposits have been demonstrated in the central nervous system (CNS) of patients suffering from a wide variety of neurodegenerative disorders including Alzheimer's disease, presenile dementia, Parkinson's disease, diabetes mellitus, myoclonic epilepsy, and cerebral palsy. The etiology of these deposits and their relationship to mechanisms of progressive neurodegeneration is unknown. In the present study, we demonstrate that the kainic acid model of limbic status epilepticus provides a useful system for the study of PAS-positive staining. The relationship between PAS-positive deposition, induction of fos-like immunoreactivity (FLI), neuronal necrosis, reactive gliosis, and blood-brain barrier breakdown following the kainic acid induction of status epilepticus was investigated. Epileptiform activity was elicited in rats by intraperitoneal administration of 10 mg/kg kainic acid and brains were examined 3, 5, 12, 24, 72, and 168 h after drug injection. Four distinct types of PAS-positive staining in rat brain were observed: type 1, extracellular matrix (ECM) or blood vessel associated-material; type 2, granular deposits; type 3, glial labelling; and type 4, neuronal labelling. Results demonstrated that the four types of PAS-positive staining were differentially associated with specific markers of neuropathology: (1) type 1 ECM staining and type 3 glia were preferentially localized to edematous tissue; (2) the majority of type 3 glia were identified as reactive astrocytes, while a minority of appeared to be proliferating microglia; (3) type 1 blood vessels labelled hemorrhaging vasculature; (4) early deposition of type 2 granules was predictive of subsequent cell loss; (5) chronic type 2 granular deposits and type 4 neuronal labelling not associated with cell death could be predicted by early changes in FLI; and (6) chronic deposition of all four forms of PAS-positive material was correlated with earlier, transient blood-brain barrier compromise. The results support the growing literature that local carbohydrate metabolism may be one of a constellation of parameters important to the development of progressive neurodegeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296356
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Periodic acid-Schiff(PAS)-positive deposits in brain following kainic acid-induced seizures: relationships to fos induction, neuronal necrosis, reactive gliosis, and blood-brain barrier breakdown (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 126-138 
    Details
    ISSN: 1432-0533
    Keywords: Neurodegeneration ; Epilepsy ; Kainic acid fos ; Gliosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Periodic acid-Schiff (PAS)-positive deposits have been demonstrated in the central nervous system (CNS) of patients suffering from a wide variety of neurodegenerative disorders including Alzheimer's disease, presenile dementia, Parkinson's disease, diabetes mellitus, myoclonic epilepsy, and cerebral palsy. The etiology of these deposits and their relationship to mechanisms of progressive neurodegeneration is unknown. In the present study, we demonstrate that the kainic acid model of limbic status epilepticus provides a useful system for the study of PAS-positive staining. The relationship between PAS-positive deposition, induction of fos-like immunoreactivity (FLI), neuronal necrosis, reactive gliosis, and blood-brain barrier breakdown following the kainic acid induction of status epilepticus was investigated. Epileptiform activity was elicited in rats by intraperitoneal administration of 10 mg/kg kainic acid and brains were examined 3, 5, 12, 24, 72, and 168 h after drug injection. Four distinct types of PAS-positive staining in rat brain were observed: type 1, extracellular matrix (ECM) or blood vessel associated-material; type 2, granular deposits; type 3, glial labelling; and type 4, neuronal labelling. Results demonstrated that the four types of PAS-positive staining were differentially associated with specific markers of neuropathology: (1) type 1 ECM staining and type 3 glia were preferentially localized to edematous tissue; (2) the majority of type 3 glia were identified as reactive astrocytes, while a minority of appeared to be proliferating microglia; (3) type 1 blood vessels labelled hemorrhaging vasculature; (4) early deposition of type 2 granules was predictive of subsequent cell loss; (5) chronic type 2 granular deposits and type 4 neuronal labelling not associated with cell death could be predicted by early changes in FLI; and (6) chronic deposition of all four forms of PAS-positive material was correlated with earlier, transient blood-brain barrier compromise. The results support the growing literature that local carbohydrate metabolism may be one of a constellation of parameters important to the development of progressive neurodegeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00296356
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Evidence for the alpha decay of108I (1991)
    Springer
    The European physical journal 338 (1991), S. 295-301 
    Details
    ISSN: 1434-601X
    Keywords: 23.60.+e ; 23.90.+w ; 27.60.+j
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A Residue Implantation Detection System has been used in conjunction with the Daresbury Recoil Mass Separator in a search for radioactivity from the unknown nuclides108I and105Te. In the reaction of 260 MeV58Ni ions with a54Fe target two new decay lines at energies of 3.730±0.025 MeV and 3.885±0.025 MeV corresponding to cross sections of approximately 0.3 μb and 0.4 μb respectively were identified in theA=108 region of the separator's focal plane. These decay lines are tentatively assigned to the alpha decays of108I. No evidence for a proton decay branch of this nuclide could be found. In a second reaction in which a50Cr target was bombarded with 230 MeV58Ni ions, no alpha decay peak from105Te could be identified. Cross section dependent half life limits were determined from which correspondingQ-value limits were deduced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01288193
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The breakup of24Mg into16O and8Be (1994)
    Springer
    The European physical journal 349 (1994), S. 349-350 
    Details
    ISSN: 1434-601X
    Keywords: 24.30.−v ; 25.70.−z ; 27.30.+t
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The breakup of24Mg into16O and8Be fragments has been studied using the reactions12C(24Mg,16O8Be)12C and12C(20Ne,16O8Be)8Be. In the latter case, discrete states are observed near 24–28 MeV of excitation in24Mg and the yield from this reaction is an order of magnitude greater than that of the former. This implies the excited configuration populated in24Mg is favoured by the transfer of an alpha-particle and would therefore suggest an association with a 4-particle 4-hole configuration. This suggests a link with the octupole stabilised deformed minimum which appears in Nilsson-Strutinsky calculations of the potential energy surface in24Mg, and also with theα —16O —α structure predicted in cranked cluster model calculations. In the excitation spectrum no states appear above 31 MeV indicating a possible band termination in disagreement with recent results using the16O+12C reaction. These results are discussed in terms of the Harvey model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01288992
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Persistence of leptospiral agglutinins in Trinidadian survey subjects (1990)
    Springer
    European journal of epidemiology 6 (1990), S. 40-44 
    Details
    ISSN: 1573-7284
    Keywords: Leptospires ; Antibody persistence ; West Indies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Participants in a survey for leptospiral agglutinating antibodies undertaken in Trinidad, West Indies, in 1977–78, were further monitored for up to 5-and-a-half years. 52 individuals with a titre ≥ 1:400 were matched for age, sex and occupation with seronegative subjects. They were re-bled twice (on average 2.38 and 4.84 years later), and changes of titre were noted. At the first follow-up, 78% of negative controls remained negative, and 22%, showed titre changes. Among the seropositive subjects, 47% showed a fall in titre, 38% showed no change, and in 15% the titre rose. New exposure rates between the original and first follow-up samples were 96/1,000 survey population per year in the controls, and 68/1,000 for the subjects with titres 〉 1:400. Between the first and second followup, 47% of the seropositive subjects lost titre, 40% showed no change, and 13% showed a rise in titre. These data demonstrate that although antibody titres may be maintained for a few years at the same level, or show a loss as is usually expected, about 8.3% of individuals in Trinidad may be infected/reinfected per year. The infection/reinfection rate is an important factor in the epidemiology of leptospirosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00155547
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    Paper (German National Licenses)
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