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  • 1
    Electronic Resource
    Electronic Resource
    The effect of systemic treatment with 5-fluorouracil on the epidermis of the guinea pig (1978)
    Springer
    Archives of dermatological research 263 (1978), S. 31-35 
    Details
    ISSN: 1432-069X
    Keywords: 5-Fluorouracil ; 3H thymidine labelling index ; Mitoses in the epidermis ; Atrophy of the epidermis ; S-phase ; 5-Fluorouracil ; 3H-Thymidin-Labelling-Index ; Mitosen in der Epidermis ; Atrophisierung der Epidermis ; DNS-Synthesezeit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Vor und während einer Behandlung mit 5-Fluorouracil (1 mg i.p. in 2tägigem Abstand/100 g KG) wurde beim Meerschweinchen der 3H-Thymidin-Labelling-Index in der Basalschicht der Epidermis bestimmt. Parallel wurde die Zahl der in der Metaphase blockierbaren Mitosen in der Epidermis mit der Colcemidmethode ermittelt. Außerdem wurden Epidermisfläche, Epidermisdicke, Zellzahl in der Epidermis und Zellgröße in der Epidermis analysiert. 5-Fluorouracil reduziert den 3H-Thymidin-Labelling-Index und die Mitoserate bei der Colcemidmethode in der gleichen Weise, wobei der Effekt erst nach einer Behandlungszeit von mehr als 22 Tagen voll zum Tragen kommt. Die Parallelität dieser Befunde läßt annehmen, daß die DNS-Synthesezeit nicht wesentlich verändert wird, wenn man sie vom Zeitpunkt der Thymidin-Synthese an rechnet. Zeitlich parallel kommt es außerdem zu einer Atrophisierung der Epidermis.
    Notes: Summary The thymidine labelling index and the mitosis rate (blocked by colcemid) in the basal cell layer of the guinea pig were determined before and during treatment with 5-fluorouracil (1 mg i.p. in 2 day's interval/100 g body weight). Additionally, the epidermal area and thickness and the number and size of cells were measured. 5-Fluorouracil equally reduces the thymidine labelling index and the mitosis rate with the full effect after treatment of at least 22 days. From these findings it is concluded that the S-phase — calculated from the end of the thymidine synthesis — is not altered. Furthermore atrophy of the epidermis runs parallel with the reduction of the 3H thymidine labelling index and the mitosis rate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446851
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  • 2
    Electronic Resource
    Electronic Resource
    Proton decay of spin isospin modes excited by the12C(6Li,6He)12N reaction (1992)
    Springer
    The European physical journal 344 (1992), S. 269-275 
    Details
    ISSN: 1434-601X
    Keywords: 25.70.Cd ; 27.20.+ n
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract First investigations of the reaction12C(6Li,6He)-12N(p)11C were used to study spin-isospin strength in the nucleus12N at ELi=156 MeV. While the6He ejectiles were detected at θHe=0° using a magnetic spectrograph, the decay protons were analysed in a wide range of backward angles (100°〈θp〈170°) with an arrangement of semiconductor strip detectors. Singles spectra were extracted as well as coincident excitation strength for the decay to low lying levels in11C. For the decay to the11C ground state angular correlations were evaluated for six different energy regions in12N*.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01303020
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    Paper (German National Licenses)
    Fulltext
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