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  • 3-O-betulinic acid esters.  (1)
  • ARIMA  (1)
  • Antidiabetic drugs  (1)
  • Cat caudate nucleus  (1)
  • Central norepinephrine lesions  (1)
Materialart
Erscheinungszeitraum
Schlagwörter
  • 1
    Digitale Medien
    Digitale Medien
    Amsterdam : Elsevier
    Phytochemistry 37 (1994), S. 837-845 
    ISSN: 0031-9422
    Schlagwort(e): 3-O-betulinic acid esters. ; Chamaecrista greggii ; Leguminosae ; anthraquinones ; cassanes ; diterpenes
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Experimental brain research 31 (1978), S. 117-130 
    ISSN: 1432-1106
    Schlagwort(e): Central norepinephrine lesions ; Enriched environments ; Functional recovery
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Adult rats were injected intraventricularly with 6-OHDA and allowed to recover for varying time periods in either an enriched colony environment or in isolation cages. When tested behaviorally in a novel environment, isolated animals showed a cyclical recovery pattern, with behavioral changes at 14 days after lesioning which were different from those seen at 2 and 45 days after lesioning. In contrast, animals housed in a colony environment showed progressive improvement and better recovery than isolates. Biochemical studies of uptake of H3NE and histofluorescence indicated that colony housed animals had enrichment effects (higher cortical NE uptake), but they were also more susceptible to 6-OHDA and did not recover well from the lesions. Isolated animals showed somewhat better recovery of NE uptake following 6-OHDA injections, especially in cortex. Because behavioral recovery from 6-OHDA was dissociated from biochemical indicators of recovery in NE circuitry, these results imply that brain systems other than NE were primarily responsible for the enhanced behavioral recovery which occurs in enriched environments.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    ISSN: 1432-0568
    Schlagwort(e): Cat caudate nucleus ; Ischemia ; Plasmalemmal glial assemblies ; Cytotoxic edema
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Selective cerebral ischemia was induced in the caudate nucleus of seven normothermic anesthetized cats through transorbital clamping of the anterolateral penetrating lenticulostriated arteries. The plasmalemma of astrocytic foot processes has been studied with the freeze-fracture technique and conventional electron microscopy 10, 15 and 30 min after ischemia. After 15 min of circulatory arrest, assemblies of intramembrane particles (IMPs) disappear in some areas of astroglial perivascular plasmalemma in the ischemic caudate nucleus. Interastrocytic gap junctions do not change significantly. 30 min after ischemia, the pericapillary astroglial end foot is expanded and organelles are greatly perturbed (cytotoxic edema). Although the function of astrocytic intramembrane particle assemblies is unclear, it is postulated that the disappearance of this membrane specialization may play a role in the pathophysiology of cytotoxic astroglial edema.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    International archives of occupational and environmental health 72 (1999), S. 366-376 
    ISSN: 1432-1246
    Schlagwort(e): Key words Pollution ; Morbidity ; Mortality ; ARIMA ; Time series ; Weather
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Objective: Evaluation of the association between air pollution and mortality and morbidity is becoming ever more complex owing to changes in inner-city air pollution, marked by decreasing values for all main pollutants save those associated with traffic. This has led to the need for the study of new epidemiological scenarios in which most pollutants are below guideline values. Nonetheless, the health effects are significant. Methods: This report presents the results of a statistically based model for real-time forecasting of mortality and morbidity in Madrid, with meteorological and pollution series serving as inputs. Results and conclusions: Not only did the models perform well with correlation coefficients between predicted and observed values (r = 0.683 for mortality, r = 0.681 for morbidity), but they enabled quantification of the impact of air pollution on mortality and morbidity (with increases ranging from 1.8% to 12% for mortality and from 2.3% to 18% for morbidity for a 25-μg/m3 increase in pollutants). Moreover, attention should be drawn to the observation that the model proved to be easy to implement and operate on a routine basis.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    European journal of clinical pharmacology 42 (1992), S. 151-154 
    ISSN: 1432-1041
    Schlagwort(e): Antidiabetic drugs ; drug utilization ; health care systems ; Spain ; DDD
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The consumption of antidiabetic drugs in a Spanish region (Extremadura) in the period 1986–1987 has been investigated by the “defined daily dose” (DDD) method. The study was done in three health care systems in the region: civil servants (“Mutualidad de Funcionarios Civiles del Estado: MUFACE”) armed forces group (“Instituto Social de las Fuerzas Armadas: ISFAS”) and the national system (“Instituto Nacional de la Salud: INSALUD”). The total consumption of antidiabetic drugs varied three-fold, ranging from 5,73 DDD per 1000 inhabitants per day (3,71 DDD per 1000 inhabitants per day for oral antidiabetic drugs and 2,02 DDD per 1000 inhabitants per day for insulin) in the civil servant group to 15,82 DDD per 1000 inhabitants per day (12 DDD per 1000 inhabitants per day for oral antidiabetic drugs and 3,82 DDD per 1000 inhabitants per day for insulins) in the armed forces. The differences were more pronounced for oral antidiabetics than for insulins. The utilization of insulin among the civil servants was about half of that by the two other groups. Of oral antidiabetics, sulphonylureas were the most frequently used by the three groups, and within them glibenclamide accounted for more than half of the DDDs, while biguanides were scarcely used in any group. The differences are difficult to assess, since they could be due to several factors, such as age-differences in the population studied, different prescribing habits, and differences in sociocultural level. The results justify further comparative studies of drug utilization in different health systems within the same region.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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