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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 1103 (1992), S. 163-171 
    ISSN: 0005-2736
    Keywords: 1,25-Dihydroxyvitamin D-3 ; ATPase, Ca^2^+- ; Basolateral membrane ; Calcium pump ; Parathyroid hormone
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-1463
    Keywords: Catechol-O-methyltransferase inhibitor ; 3-O-methyldopa ; levodopa ; Parkinson's disease ; tolcapone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of tolcapone, a catechol-O-methyltransferase inhibitor, on the bioavailability and efficacy of levodopa were evaluated in 12 patients with Parkinson's disease (PD), 8 of whom showed signs of daily motor fluctuations (wearing-off phenomenon). Motor disabilities were assessed in 12 patients at 7 time points before and after the chronic administration of tolcapone using the Unified Parkinson's Disease Rating Scale (UPDRS). The UPDRS score was improved at all points of determination. Eight patients with wearing-off phenomenon on levodopa showed symptomatic improvement on the combination. The area under the curve (AUC) for levodopa increased by 34% (p=0.0059) after the administration of tolcapone. The elimination half-life (T1/2) of levodopa was significantly prolonged by 81% (p=0.0001) after the treatment. The AUC of 3-O-methyldopa, a metabolite of levodopa, was decreased by 79% (p=0.0001) and the Cmax (maximum concentration) was also decreased by 80% after the administration (p=0.0001) of tolcapone. The combination of tolcapone and levodopa was well tolerated. Our findings suggest that tolcapone improves the pharmacokinetics of levodopa in plasma and motor symptoms of fluctuating PD patients. It is suggested that tolcapone may be a useful drug adjunct to levodopa in treating patients with PD with wearing-off phenomena.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1920
    Keywords: Brain neoplasm ; Acoustic neurinoma ; Meningioma ; Cerebellopontine angle ; Neoplasm
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Forty-two acoustic neurinomas and seven meningiomas in the cerebellopontine angle were reviewed, and the radiological differential diagnosis of these tumors is discussed. Though enlarged internal auditory meati and characteristic CT findings were reasonably reliable indicators for the diagnosis of acoustic neurinomas, it was angiography which substantiated their correct diagnosis. An arcuate vein was frequently demonstrated with acoustic neurinomas, but never with meningiomas. Visualization of tangled veins seems to favor a diagnosis of acoustic neurinomas. Contrary to earlier reports, tumor stains were most frequently visualized using selective external carotid arteriography. The degree of tumor stains did not aid in differentiating acoustic neurinomas from meningiomas. The importance of using angiotomography, especially in the anteroposterior projection, and external carotid angiography during prolonged injections of large amounts of contrast media, is emphasized.
    Type of Medium: Electronic Resource
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