ISSN:
1432-1041
Keywords:
aniracetam
;
3-OH aniracetam
;
hyperventilation-induced ischaemia
;
cerebral ischaemia model
;
neuropharmacology
;
EEG
;
cognition tests
;
noötropics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Standardized hyperventilation in young subjects induces changes in the EEG, a decrease in the velocity of the cerebral blood flow and a decline in cognitive performance, which are comparable to those occurring in patients with cerebral ischaemia. The anti-ischaemic properties of aniracetam and 3-OH aniracetam were tested in this model. A single oral dose of 3-OH aniracetam 1500 mg appeared to have the most pronounced effect on hyperventilation-induced EEG changes and cognitive deterioration. The test drugs had no effect on the heart rate or blood flow velocity. The effects agree with those of other drugs classified as noötropics.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00637744
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