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  • Histochemistry  (2)
  • Renal neoplasms  (2)
  • 3-hydroxybutyric acid  (1)
  • CCl4  (1)
  • Cecum  (1)
  • Colon  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Elevated concentrations of the β-subunit of S100 protein in renal cell tumors in rats (1994)
    Springer
    Urological research 22 (1994), S. 251-255 
    Details
    ISSN: 1434-0879
    Schlagwort(e): S100 protein ; Rat ; Carcinogenesis ; Renal neoplasms
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Concentrations of α and β-subunits of S100 protein (S100-α and S100-β) in rat kidney neoplasms, including renal cell and mesenchymal tumors, were determined using a highly sensitive enzyme immunoassay, and both types immunohistochemically localized in tissue sections. Concentration of S100-α in each histological type of rat tumor were lower than in normal kidney, whereas levels of S100-β (mean±SE: 29.7±14.2 ng/mg protein, n=15) in renal cell tumors were significantly higher than in normal kidneys (0.55±0.06 ng/mg protein, n=7), or mesenchymal tumors (1.21±0.43 ng/mg protein, n=9). In normal rat kidney tissues S100-α was immunohistochemically positive in epithelial cells of the distal tubules, the thin limbs of loops of Henle, and the collecting ducts. No appreciable immunostaining for S100-β was found in any nephron segment. Both S100-α and S100-β were positive for renal cell tumors, indicating new appearance of the latter during renal carcinogenesis in rats.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00541902
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  • 2
    Digitale Medien
    Digitale Medien
    Elevated concentrations of γ-enolase in renal cell tumors in rats: similarity to renal cell carcinoma in man (1996)
    Springer
    Urological research 24 (1996), S. 375-379 
    Details
    ISSN: 1434-0879
    Schlagwort(e): Enolase ; Isozymes ; Rat ; Renal neoplasms
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Concentrations of enolase isozymes in normal kidney and renal cell tumors in rats were determined using a highly sensitive enzyme immunoassay, and the isozymes were immunohistochemically localized in tissue sections. Levels of α-enolase in renal cell turnors were significantly lower than in normal kidney, whereas those of γ-enolase were significantly elevated (mean ±SD:211±129 ng/mg protein, n=15, as compared to 27.1±2.9 ng/mg protein, n=7). The proportion of γ-enolase in the total enolases in the tumor tissues (1.6±0.5%) was significantly higher than in normal kidney (0.15±0.005). Immunohistochemistry revealed epithelial cells of all nephron segments to be positive for the α-isozyme, whereas γ-enolase staining was strongly positive only in the loops of Henle, being faint in the distal tubules and absent in the proximal tubules. Both α- and γ-enolases demonstrated positive immunostaining in all of the seven renal cell tumors studied. These findings indicate that an isozyme switch from α- to γ-enolase occurs during rat kidney carcinogenesis, taking into account the derivation from proximal tubules, consistent with the findings for renal cell carcinomas in man.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00389796
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  • 3
    Digitale Medien
    Digitale Medien
    Pleomorphism of hepatic regeneration (1984)
    Springer
    Research in experimental medicine 184 (1984), S. 49-57 
    Details
    ISSN: 1433-8580
    Schlagwort(e): Hepatic regeneration ; Partial hepatectomy ; Liver damage ; Repair of liver damage ; CCl4
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The pleomorphism of hepatic regeneration was studied in acute liver injury and partial hepatectomy of rats. Increases in3H-thymidine incorporation into the liver DNA fraction and in liver ornithine decarboxylase (ODC) activity were observed similarly in acute liver injury and following a two-thirds partial hepatectomy in normal rats. However, the increase in serum AFP levels was significant only in carbon tetrachloride (CCl4)-treated rats, and the portal-peripheral vein difference in plasma glucagon concentrations was great only in rats that underwent a partial hepatectomy. The weight of the remaining liver increased rapidly following a 67% hepatectomy in normal rats, but not in cirrhotic rats, of which three of five died within 6 days. Increases in liver prostaglandin E levels,14C-orotate incorporation into the liver RNA fraction and hepatic ODC activity were observed up to 10 h following a partial hepatectomy of normal liver but not after similar removal of cirrhotic liver. Three kinds of hepatic regeneration, i.e., normal and pathologic regeneration following surgical removal of either normal or injured liver and repair of liver damage following chemically induced liver deficiency, were proposed from the observations.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01852222
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  • 4
    Digitale Medien
    Digitale Medien
    Alpha-amylase inhibitor increases plasma 3-hydroxybutyric acid in food-restricted rats (1995)
    Springer
    Cellular and molecular life sciences 51 (1995), S. 585-588 
    Details
    ISSN: 1420-9071
    Schlagwort(e): α-amylase inhibitor ; plasma glucose ; 3-hydroxybutyric acid ; high starch diet
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract The effect on energy metabolism of delayed absorption of starch by inhibition of α-amylase was examined by considering levels of plasma glucose and 3-hydroxybutyric acid (3-OHBA) in rats. Addition of α-amylase inhibitor (αAI) to a high starch diet delayed the plasma glucose response after feeding: peak plasma glucose levels in the control group occurred 15 min after feeding, whereas in the αAI group this peak did not occur until 30 min after. The total plasma glucose response was not different between the two groups. Plasma 3-OHBA levels 1 day after food restriction increased approximately five-fold in both groups. After 3 days of food restriction, the αAI group maintained the same level of plasma 3-OHBA as after 1 day of food restriction, while the control group showed significantly decreased levels of 3-OHBA. After 3 days of food restriction, plasma insulin levels were significantly decreased in the αAI group compared with the corresponding levels of the control group and with levels before the restriction. There was no significant difference in body weight between the two groups. These findings suggest that delayed hyperglycemia due to delayed absorption of starch following αAI loading may attenuate insulin secretion, leading to altered metabolism of 3-OHBA during the delayed response to energy deficit.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02128748
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  • 5
    Digitale Medien
    Digitale Medien
    Influence of short-chain fatty acids and osmolality on mucin release in the rat colon (1981)
    Springer
    Cell & tissue research 219 (1981), S. 371-377 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Short-chain fatty acids ; Osmolality ; Mucin release ; Colon (rat) ; Histochemistry ; Goblet cells ; Vacuolated cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The influence of short-chain fatty acids (SCFA) and osmolality on mucin release in the rat colon was studied histochemically by determining number of stained mucin-containing cells. SCFA did not significantly influence the number of cells staining for mucin. Hypertonic solutions (360 mosm/l) did not affect mucin release in the proximal colon, but stimulated mucin release in the distal colon. Solutions of lower osmolality (300 or 250 mosm/l) caused a considerable release of mucin from goblet cells as well as vacuolated cells in both the proximal and the distal colon; the lower the osmolality, the more mucin was released. The mucosa of the distal colon was conspicuously affected by solutions of lower osmolality. The influence of osmolality on mucin release was entirely local.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00210155
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  • 6
    Digitale Medien
    Digitale Medien
    Luminal mucin in the large intestine of mice, rats and guinea pigs (1981)
    Springer
    Cell & tissue research 219 (1981), S. 629-635 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Cecum ; Colon ; Goblet cell ; Vacuolated cell ; Histochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The luminal and epithelial mucin was studied histochemically in the large intestine of mice (Mus musculus), rats (Rattus rattus) and guinea pigs (Cavia porcellus) using freeze-substitution and vapor-fixation methods. Neutral mucin decreased and acid mucin increased in the epithelium from the cecum to the distal colon. Vacuolated cells contained more acid mucin than goblet cells. Luminal mucin always contained neutral mucin, which formed the main constituents in the cecum and in the proximal colon. Sialo-mucin increased from the cecum to the distal colon. Sulfo-mucin appeared only in the distal colon. Except in the cecum a luminal mucin layer (LML) was found at the epithelial surface. In the proximal colon LML was not entirely continuous and varied in composition and thickness (182.4 ± 170.1, 150.5 ± 110.4, 30.0 ± 28.9 (μm), in mice, rats and guinea pigs, respectively), and contained many bacteria. In the distal colon LML was compact, homogeneous and thin (33.6 ± 18.8, 16.1 ± 7.3, 29.1 ± 20.0 (μm), in mice, rats and guinea pigs, respectively) containing few bacteria. Possible functions of the luminal mucin and their regional differentiations were discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00210000
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