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  • Slow inward current  (2)
  • 4-Aminopyridine  (1)
  • Cardiac muscle  (1)
  • DNA fingerprinting, cultivar identification  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Increase in the slow inward current by intracellularly applied nifedipine and nicardipine in single ventricular cells of the guinea-pig heart
    Amsterdam : Elsevier
    Journal of Molecular and Cellular Cardiology 16 (1984), S. 1173-1177 
    Details
    ISSN: 0022-2828
    Schlagwort(e): Adenosine 3',5'-cyclic monophosphate phosphodiesterase ; Dihydropyridine calcium antagonist ; Slow inward current
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1016/S0022-2828(84)80043-7
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Inhibition of the slow inward current and the time-dependent outward current of mammalian ventricular muscle by gentamicin (1982)
    Springer
    Pflügers Archiv 394 (1982), S. 243-249 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Papillary muscle ; Gentamicin ; Slow inward current ; Calcium ; Time-dependent outward current
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The aminoglycoside antibiotic, gentamicin (GM), depressed the plateau phase and shortened the duration of the action potential in guinea pig papillary muscle. Its effect on the membrane currents was studied by a single sucrose gap voltage clamp method. The slow inward current (is) was remarkably diminished by GM with little change in its time course, in the voltage-dependency of the steady-state inactivation and activation or in its reversal potential. The maximal amplitude of is, obtained by subtracting the Co2+-resistant current, was reduced to 57% by 0.1 mmol/l GM and almost reduced to zero by 1 mmol/l GM. The efficacy of GM in inhibiting is was reduced by increasing the external Ca2+ concentration from 1.8 to 5.4 or 10.8 mmol/l, but not by the application of adrenaline. The time-dependent outward current (iK) was also decreased by GM but only at higher concentrations. It is proposed that the depressant action of GM on is was due to a blockade of slow channels, whereby GM may have dislocated Ca from the binding sites at slow channels on the external surface of the membrane.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00589099
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  • 3
    Digitale Medien
    Digitale Medien
    Positive inotropic effect of 4-aminopyridine on dog ventricular muscle (1979)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 307 (1979), S. 207-212 
    Details
    ISSN: 1432-1912
    Schlagwort(e): 4-Aminopyridine ; Cardiac muscle ; Relaxation ; Action potential ; Catecholamines ; Calcium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary 1. In trabecular muscles obtained from the right ventricle of untreated dogs 4-aminopyridine (4-AP) (0.1–10 mM) increased the force of contraction elicited by electrical driving at 0.5 Hz. 2. This effect was associated with increases in mean velocities of force development and relaxation. The time to peak force was not changed by 4-AP and the relaxation time was increased by 3 and 10 mM 4-AP. 3. In ventricular muscles treated with the β-adrenoceptor blocking agent, pindolol, or in those obtained from dogs pretreated with reserpine the positive inotropic effect was reduced. 4. In such muscles 4-AP scarcely increased the mean velocity of force development and slightly increased the time to peak force. Marked prolongation of the relaxation time and a decrease in mean velocity of relaxation were characteristic of isometric contractions of such muscles in the presence of 4-AP. 5. These results indicate that the positive inotropic effect of 4-AP is sum of two effects, one being due to the release of endogenous catecholamines and the other to a possible direct action on cardiac muscle. 6. In muscles treated with pindolol or those obtained from dogs pretreated with reserpine 10 mM 4-AP elevated the resting force. 7. These observations suggest that 4-AP causes a persisting elevation of cytosolic Ca2+ in cardiac muscle cells. 8. In pindolol-treated muscles 4-AP prolonged the action potential duration. However, the prolongation of the action potential duration produced by 4-AP was much smaller than that of the relaxation time. Even with 10 mM 4-AP the resting membrane potential remained unchanged. 9. The above results suggest that the effects of 4-AP on the contraction and resting force of ventricular muscle may not be secondary to the effect on the transmembrane potential. 10. All the results taken together suggest that the primary action of 4-AP on ventricular muscle may not be to allow increased or prolonged entry of extracellular Ca2+ but rather may be either to promote the release of Ca2+ from intracellular binding or storage sites or to slow the binding of Ca2+ to intracellular structures. The prolongation of the action potential duration may be a consequence of change in calcium binding to the plasma membrane.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00505935
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  • 4
    Digitale Medien
    Digitale Medien
    DNA fingerprinting in soybean (Glycine max (L.) Merrill) with oligonucleotide probes for simple repetitive sequences (1994)
    Springer
    Euphytica 80 (1994), S. 129-136 
    Details
    ISSN: 1573-5060
    Schlagwort(e): Glycine max ; DNA fingerprinting, cultivar identification ; simple repetitive sequences ; oligonucleotide probes ; soybean
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Summary Soybean DNA fingerprints were analyzed by digoxigenin-labeled oligonucleotide probes complementary to simple repetitive sequences. The clearest and most polymorphic patterns were obtained with (AAT)6 as a probe, with which all 47 soybean cultivars tested could be distinguished. However, DNA fingerprints of individuals within cultivars showed the same pattern. Using (CT)8, (GAA)5 or (AAGG)4 as probes, clear polymorphic patterns among cultivars and accessions in the subgenus Soja (Glycine max and Glycine soja) were not observed, while quite different patterns were found in accessions in the subgenus Glycine. The results suggest that G. max and G. soja are closer in their genome structure. DNA fingerprints of reciprocal crosses between cultivars and accessions in the subgenus Soja were similar, and contained bands of both parents. In an F2 population from these crosses, such bands segregated in a Mendelian fashion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00039308
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